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ONTOLOGY REPORT - ANNOTATIONS


Term:Ire1 complex
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Accession:GO:1990332 term browser browse the term
Definition:A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript.
Comment:An example of this is Ire1 in Escherichia coli (P32361) in PMID:18191223 (inferred from direct assay).
Synonyms:exact_synonym: IRE1 dimer
 related_synonym: ERN1 complex
 xref: IntAct:EBI-8872439


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  cellular_component 19843
    protein-containing complex 5779
      membrane protein complex 1210
        Ire1 complex 0
Path 2
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  cellular_component 19843
    protein-containing complex 5779
      catalytic complex 1437
        transferase complex 805
          transferase complex, transferring phosphorus-containing groups 261
            protein kinase complex 102
              serine/threonine protein kinase complex 84
                Ire1 complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.