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ONTOLOGY REPORT - ANNOTATIONS


Term:dense core granule exocytosis
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Accession:GO:1990504 term browser browse the term
Definition:The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels.
Synonyms:exact_synonym: dense core vesicle exocytosis


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dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadps2 calcium dependent secretion activator 2 JBrowse link 4 50,326,447 50,861,161 RGD:1600115
dense core granule docking term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1624291
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1624291
dense core granule priming term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:12050107
RGD:13792537
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:12050107
RGD:13792537
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:13792537
G Unc13d unc-13 homolog D JBrowse link 10 104,613,907 104,628,664 RGD:12050107
negative regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:11541109
neuronal dense core vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1600115
RGD:1624291
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1600115
RGD:1624291
positive regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:1624291
presynaptic dense core vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cadps calcium dependent secretion activator JBrowse link 15 15,275,489 15,690,575 RGD:1600115
RGD:1624291
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1624291
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:13702162
G Unc13a unc-13 homolog A JBrowse link 16 20,056,398 20,103,951 RGD:1600115
RGD:13792537
RGD:1624291
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1624291
RGD:13792537
G Unc13c unc-13 homolog C JBrowse link 8 80,202,736 80,656,363 RGD:13792537
regulation of dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baiap3 BAI1-associated protein 3 JBrowse link 10 14,601,133 14,613,881 RGD:1624291
regulation of presynaptic dense core granule exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:13702177
G Syt4 synaptotagmin 4 JBrowse link 18 24,172,580 24,181,989 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    cellular process 18361
      vesicle-mediated transport 1596
        exocytosis 416
          regulated exocytosis 291
            calcium-ion regulated exocytosis 77
              dense core granule exocytosis 11
                dense core granule docking 2
                dense core granule priming 4
                negative regulation of dense core granule exocytosis 1
                neuronal dense core vesicle exocytosis + 8
                positive regulation of dense core granule exocytosis 1
                regulation of dense core granule exocytosis 1
Path 2
Term Annotations click to browse term
  biological_process 19576
    localization 6430
      establishment of localization 4940
        transport 4800
          secretion 1378
            secretion by cell 1184
              exocytosis 416
                regulated exocytosis 291
                  calcium-ion regulated exocytosis 77
                    dense core granule exocytosis 11
                      dense core granule docking 2
                      dense core granule priming 4
                      negative regulation of dense core granule exocytosis 1
                      neuronal dense core vesicle exocytosis + 8
                      positive regulation of dense core granule exocytosis 1
                      regulation of dense core granule exocytosis 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.