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ONTOLOGY REPORT - ANNOTATIONS


Term:PCSK9-LDLR complex
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Accession:GO:1990666 term browser browse the term
Definition:A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway.
Synonyms:exact_synonym: PCSK9/LDL-R complex;   PCSK9:low-density lipoprotein receptor complex
 related_synonym: PCSK9:EGF-A complex


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PCSK9-LDLR complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:1600115
RGD:1624291
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 5 126,031,368 126,053,726 RGD:1624291

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  cellular_component 19949
    protein-containing complex 5829
      PCSK9-LDLR complex 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.