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ONTOLOGY REPORT - ANNOTATIONS


Term:HFE-transferrin receptor complex
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Accession:GO:1990712 term browser browse the term
Definition:A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.


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HFE-transferrin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin IEA Ensembl GO_REF:0000107 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997
JBrowse link
G HFE homeostatic iron regulator IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr35:24,031,479...24,038,922
Ensembl chr35:24,031,387...24,042,413
JBrowse link
G HJV hemojuvelin BMP co-receptor IEA Ensembl GO_REF:0000107 NCBI chr17:58,792,647...58,797,504
Ensembl chr17:58,793,247...58,797,373
JBrowse link
G LOC477072 serotransferrin IEA Ensembl GO_REF:0000107 NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845
JBrowse link
G TF transferrin IEA Ensembl GO_REF:0000107 NCBI chr23:30,578,853...30,634,510
Ensembl chr23:30,595,704...30,683,845
JBrowse link
G TFR2 transferrin receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:9,059,501...9,076,646
Ensembl chr 6:9,060,629...9,076,158
JBrowse link
G TFRC transferrin receptor IEA Ensembl GO_REF:0000107 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16531
    protein-containing complex 5149
      receptor complex 394
        plasma membrane signaling receptor complex 181
          HFE-transferrin receptor complex 7
Path 2
Term Annotations click to browse term
  cellular_component 16531
    cellular anatomical entity 16390
      cell periphery 4824
        plasma membrane 4675
          plasma membrane protein complex 538
            plasma membrane signaling receptor complex 181
              HFE-transferrin receptor complex 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.