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Term:HFE-transferrin receptor complex
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Accession:GO:1990712 term browser browse the term
Definition:A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.

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HFE-transferrin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin IDA (PMID:9990067) BHF-UCL PMID:9990067 NCBI chr15:44,711,492...44,718,145
Ensembl chr15:44,711,487...44,718,877
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A IC (PMID:24904118) BHF-UCL PMID:24904118 NCBI chr10:86,755,786...86,927,969
Ensembl chr10:86,756,601...86,932,838
Ensembl chr10:86,756,601...86,932,838
JBrowse link
G BMPR1B bone morphogenetic protein receptor type 1B IC (PMID:24904118) BHF-UCL PMID:24904118 NCBI chr 4:94,757,955...95,158,453
Ensembl chr 4:94,757,955...95,158,448
JBrowse link
G HFE homeostatic iron regulator IEA
(PMID:12704209), (PMID:22728873), (PMID:9465039), (PMID:9546397), (PMID:9990067) InterPro
PMID:9465039, PMID:9546397, PMID:9990067, PMID:12704209, PMID:22728873 GO_REF:0000002 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HJV hemojuvelin BMP co-receptor IDA
(PMID:22728873) BHF-UCL
PMID:22728873 GO_REF:0000002 NCBI chr 1:146,017,470...146,021,735
Ensembl chr 1:146,017,468...146,036,746
JBrowse link
G TF transferrin IDA (PMID:9546397) BHF-UCL PMID:9546397 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641
JBrowse link
G TFR2 transferrin receptor 2 IDA (PMID:12704209), (PMID:22728873) BHF-UCL PMID:12704209, PMID:22728873 NCBI chr 7:100,620,420...100,641,552
Ensembl chr 7:100,620,416...100,642,779
JBrowse link
G TFRC transferrin receptor IDA (PMID:9465039), (PMID:9546397), (PMID:9990067) BHF-UCL PMID:9465039, PMID:9546397, PMID:9990067 NCBI chr 3:196,018,694...196,082,123
Ensembl chr 3:196,027,183...196,082,096
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19335
    protein-containing complex 5896
      receptor complex 555
        plasma membrane signaling receptor complex 334
          HFE-transferrin receptor complex 8
Path 2
Term Annotations click to browse term
  cellular_component 19335
    cellular anatomical entity 19099
      cell periphery 6075
        plasma membrane 5938
          plasma membrane protein complex 738
            plasma membrane signaling receptor complex 334
              HFE-transferrin receptor complex 8
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.