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ONTOLOGY REPORT - ANNOTATIONS


Term:HFE-transferrin receptor complex
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Accession:GO:1990712 term browser browse the term
Definition:A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.


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HFE-transferrin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:122,147,687...122,153,082
Ensembl chr 2:122,147,686...122,153,083
JBrowse link
G Hfe homeostatic iron regulator IDA
ISO
(MGI:3695785|PMID:16893896) BHF-UCL
MGI
PMID:16893896 GO_REF:0000096, MGI:3695785, MGI:4834177 NCBI chr13:23,702,034...23,710,854
Ensembl chr13:23,702,034...23,710,854
JBrowse link
G Hjv hemojuvelin BMP co-receptor ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 3:96,525,163...96,529,216
Ensembl chr 3:96,525,172...96,529,210
JBrowse link
G Tfr2 transferrin receptor 2 ISO
IDA
(MGI:3695785|PMID:16893896) MGI
BHF-UCL
PMID:16893896 GO_REF:0000096, MGI:3695785, MGI:4834177 NCBI chr 5:137,569,822...137,588,081
Ensembl chr 5:137,569,840...137,587,481
JBrowse link
G Tfrc transferrin receptor ISO
IDA
(MGI:3695785|PMID:16893896) MGI
BHF-UCL
PMID:16893896 GO_REF:0000096, MGI:3695785, MGI:4834177 NCBI chr16:32,608,896...32,632,794
Ensembl chr16:32,608,920...32,632,794
JBrowse link
G Trf transferrin ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 9:103,208,876...103,230,286
Ensembl chr 9:103,204,001...103,230,444
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 23184
    protein-containing complex 5493
      receptor complex 417
        plasma membrane signaling receptor complex 188
          HFE-transferrin receptor complex 6
Path 2
Term Annotations click to browse term
  cellular_component 23184
    cellular anatomical entity 19097
      cell periphery 5473
        plasma membrane 5336
          plasma membrane protein complex 564
            plasma membrane signaling receptor complex 188
              HFE-transferrin receptor complex 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.