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ONTOLOGY REPORT - ANNOTATIONS


Term:HFE-transferrin receptor complex
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Accession:GO:1990712 term browser browse the term
Definition:A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.


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HFE-transferrin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin IEA Ensembl GO_REF:0000107 NCBI chr 1:126,865,767...126,878,501
Ensembl chr 1:126,835,143...126,981,582
JBrowse link
G B2M beta-2-microglobulin IEA Ensembl GO_REF:0000107 NCBI chr 1:126,837,721...126,844,043
Ensembl chr 1:126,835,143...126,981,582
JBrowse link
G HFE homeostatic iron regulator IEA Ensembl
InterPro
GO_REF:0000002, GO_REF:0000107 NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,768,741
JBrowse link
G HJV hemojuvelin BMP co-receptor IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 4:99,327,989...99,332,647
Ensembl chr 4:99,328,053...99,332,647
JBrowse link
G TF transferrin IEA Ensembl GO_REF:0000107 NCBI chr13:74,930,655...74,970,599
Ensembl chr13:74,930,655...74,970,599
JBrowse link
G TFR2 transferrin receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr 3:8,539,316...8,553,993
Ensembl chr 3:8,539,318...8,578,884
JBrowse link
G TFRC transferrin receptor IEA Ensembl GO_REF:0000107 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,594...134,000,278
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 16945
    protein-containing complex 4975
      receptor complex 378
        plasma membrane signaling receptor complex 179
          HFE-transferrin receptor complex 7
Path 2
Term Annotations click to browse term
  cellular_component 16945
    cellular anatomical entity 16805
      cell periphery 5144
        plasma membrane 5001
          plasma membrane protein complex 529
            plasma membrane signaling receptor complex 179
              HFE-transferrin receptor complex 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.