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Term:HFE-transferrin receptor complex
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Accession:GO:1990712 term browser browse the term
Definition:A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.

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HFE-transferrin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin ISO (PMID:9990067) RGD PMID:9990067 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Hfe homeostatic iron regulator ISO
(PMID:12704209), (PMID:22728873), (PMID:9465039), (PMID:9546397), (PMID:9990067)
PMID:9465039, PMID:9546397, PMID:9990067, PMID:12704209, PMID:16893896, PMID:22728873 GO_REF:0000002, MGI:MGI:3695785 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Hjv hemojuvelin BMP co-receptor ISO
PMID:22728873 GO_REF:0000107 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Tf transferrin ISO (PMID:9546397) RGD PMID:9546397 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfr2 transferrin receptor 2 ISO (MGI:MGI:3695785|PMID:16893896)
(PMID:12704209), (PMID:22728873)
RGD PMID:12704209, PMID:16893896, PMID:22728873 MGI:MGI:3695785 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
G Tfrc transferrin receptor ISO (MGI:MGI:3695785|PMID:16893896)
(PMID:9465039), (PMID:9546397), (PMID:9990067)
RGD PMID:9465039, PMID:9546397, PMID:9990067, PMID:16893896 MGI:MGI:3695785 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20610
    protein-containing complex 6104
      receptor complex 412
        plasma membrane signaling receptor complex 186
          HFE-transferrin receptor complex 6
Path 2
Term Annotations click to browse term
  cellular_component 20610
    cellular anatomical entity 20359
      cell periphery 6477
        plasma membrane 6318
          plasma membrane protein complex 566
            plasma membrane signaling receptor complex 186
              HFE-transferrin receptor complex 6
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.