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ONTOLOGY REPORT - ANNOTATIONS


Term:HFE-transferrin receptor complex
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Accession:GO:1990712 term browser browse the term
Definition:A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription.


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HFE-transferrin receptor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2-microglobulin ISO (PMID:9990067) BHF-UCL PMID:9990067 NCBI chrNW_004936471:7,646,504...7,655,656 JBrowse link
G Hfe homeostatic iron regulator ISO (PMID:12704209), (PMID:22728873), (PMID:9465039), (PMID:9546397), (PMID:9990067)
(MGI:3695785|PMID:16893896)
BHF-UCL PMID:9465039, PMID:9546397, PMID:9990067, PMID:12704209, PMID:16893896, PMID:22728873 MGI:3695785 NCBI chrNW_004936671:1,940,079...1,947,574 JBrowse link
G Hjv hemojuvelin BMP co-receptor ISO (PMID:22728873) BHF-UCL PMID:22728873 NCBI chrNW_004936867:742,539...747,035 JBrowse link
G Tf transferrin ISO (PMID:9546397) BHF-UCL PMID:9546397 NCBI chrNW_004936529:6,856,042...6,895,989 JBrowse link
G Tfr2 transferrin receptor 2 ISO (PMID:12704209), (PMID:22728873)
(MGI:3695785|PMID:16893896)
BHF-UCL PMID:12704209, PMID:16893896, PMID:22728873 MGI:3695785 NCBI chrNW_004936543:667,570...681,872 JBrowse link
G Tfrc transferrin receptor ISO (PMID:9465039), (PMID:9546397), (PMID:9990067)
(MGI:3695785|PMID:16893896)
BHF-UCL PMID:9465039, PMID:9546397, PMID:9990067, PMID:16893896 MGI:3695785 NCBI chrNW_004936784:696,738...728,385 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12106
    protein-containing complex 3865
      receptor complex 290
        plasma membrane signaling receptor complex 153
          HFE-transferrin receptor complex 6
Path 2
Term Annotations click to browse term
  cellular_component 12106
    cellular anatomical entity 11960
      cell periphery 3340
        plasma membrane 3210
          plasma membrane protein complex 406
            plasma membrane signaling receptor complex 153
              HFE-transferrin receptor complex 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.