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ONTOLOGY REPORT - ANNOTATIONS


Term:Wnt signalosome
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Accession:GO:1990909 term browser browse the term
Definition:A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
Comment:Within the Wnt signalosome, beta-catenin phosphorylation is inhibited through internalization of the signalosome complex, resulting in the sequestration of GSK3-beta into multi-vesicular bodies. No longer phosphorylated and targeted for degradation, beta-catenin is free to enter the nucleus and modulate downstream transcription.
Synonyms:exact_synonym: LRP5/6 signalosome;   Wnt signalosome complex;   Wnt-LRP5/6 signalosome
 narrow_synonym: LRP6 signalosome


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Wnt signalosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgra2 adhesion G protein-coupled receptor A2 JBrowse link 16 69,094,587 69,133,015 RGD:1624291
G Axin1 axin 1 RGD:1624291
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1624291
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:1624291
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1624291
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:1624291
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G Reck reversion-inducing-cysteine-rich protein with kazal motifs JBrowse link 5 59,348,568 59,415,169 RGD:1624291

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  cellular_component 19843
    protein-containing complex 5779
      Wnt signalosome 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.