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Term:NPHP complex
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Accession:GO:1990957 term browser browse the term
Definition:A protein complex that is located at the ciliary transition zone and consists of the NPHP4 and NPHP1 proteins. It acts as an organiser of the transition zone inner structure, specifically the Y-shaped links, in conjunction with the MKS complex. It is involved in ciliary protein trafficking and is required for correct functioning of the WNT and Hippo signaling pathways.
Comment:Although there is some evidence, it's still unclear if the MKS and NPHP complexes are constituent parts of the ciliary Y-shaped links or are simply responsible for aligning and attaching the Y-shaped links to the cilium membrane and axoneme.
Synonyms:exact_synonym: NPHP module

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  cellular_component 20118
    protein-containing complex 5962
      NPHP complex 0
Path 2
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  cellular_component 20118
    cellular anatomical entity 19774
      cell projection 2527
        plasma membrane bounded cell projection 2460
          cilium 681
            ciliary transition zone 76
              NPHP complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.