Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of G1/S transition of mitotic cell cycle
go back to main search page
Accession:GO:2000134 term browser browse the term
Definition:Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.


show annotations for term's descendants           Sort by:
 
negative regulation of G1/S transition of mitotic cell cycle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator IEA
ISO
GO_REF:0000107
(MGI:MGI:2679141|PMID:12855558), (MGI:MGI:3032471|PMID:14660795)
Ensembl
RGD
PMID:12855558, PMID:14660795 GO_REF:0000107, MGI:MGI:2679141, MGI:MGI:3032471 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Brd7 bromodomain containing 7 ISO (PMID:16265664) RGD PMID:16265664 NCBI chr19:19,672,780...19,701,484
Ensembl chr19:19,672,856...19,701,484
JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 ISO (MGI:MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:MGI:5520006 NCBI chr17:43,867,243...43,878,734
Ensembl chr17:43,868,191...43,879,839
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 IDA RGD PMID:28587927 RGD:13515054 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO (PMID:25466836) RGD PMID:25466836 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdc73 cell division cycle 73 ISO
IEA
ISS
(PMID:16989776)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:16989776 GO_REF:0000024, GO_REF:0000107 NCBI chr13:60,403,771...60,496,511
Ensembl chr13:60,403,771...60,496,511
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 ISO (PMID:23781148) RGD PMID:23781148 NCBI chr 1:219,345,638...219,347,709
Ensembl chr 1:219,345,918...219,347,728
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO UniProtKB:Q96LR5 (PMID:21628527) RGD PMID:21628527 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B ISO
IEA
(MGI:MGI:5461251|PMID:23154982)
GO_REF:0000107
RGD
Ensembl
PMID:23154982 GO_REF:0000107, MGI:MGI:5461251 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
G Ctdsp1 CTD small phosphatase 1 ISO (MGI:MGI:5494382|PMID:22210897) RGD PMID:22210897 MGI:MGI:5494382 NCBI chr 9:81,672,613...81,677,979
Ensembl chr 9:81,672,758...81,677,979
JBrowse link
G Ctdsp2 CTD small phosphatase 2 ISO (MGI:MGI:5494382|PMID:22210897) RGD PMID:22210897 MGI:MGI:5494382 NCBI chr 7:70,283,683...70,291,795
Ensembl chr 7:70,283,710...70,288,568
JBrowse link
G Ctdspl CTD small phosphatase like ISO (MGI:MGI:5494382|PMID:22210897) RGD PMID:22210897 MGI:MGI:5494382 NCBI chr 8:127,065,292...127,726,248
Ensembl chr 8:127,702,534...127,726,127
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 ISO (PMID:18936100) RGD PMID:18936100 NCBI chr 6:93,740,440...93,751,003
Ensembl chr 6:93,740,586...93,749,809
JBrowse link
G Dcun1d3 defective in cullin neddylation 1 domain containing 3 ISO
ISS
(PMID:18823379)
GO_REF:0000024
RGD
UniProt
PMID:18823379 GO_REF:0000024 NCBI chr 1:189,626,442...189,666,440
Ensembl chr 1:189,627,972...189,666,440
JBrowse link
G E2f7 E2F transcription factor 7 ISO
ISS
(MGI:MGI:5448509|PMID:22180533)
GO_REF:0000024
RGD
UniProt
PMID:22180533 GO_REF:0000024, MGI:MGI:5448509 NCBI chr 7:53,275,659...53,318,261
Ensembl chr 7:53,275,676...53,316,481
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO MGI:MGI:2661097 (MGI:MGI:3846264|PMID:19303854) RGD PMID:19303854 MGI:MGI:3846264 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Fam107a family with sequence similarity 107, member A IEA
ISO
ISS
GO_REF:0000107
(PMID:28604741)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:28604741 GO_REF:0000024, GO_REF:0000107 NCBI chr15:18,399,145...18,415,959
Ensembl chr15:18,399,515...18,415,965
JBrowse link
G Fbxo7 F-box protein 7 ISO (MGI:MGI:5317390|PMID:21652635) RGD PMID:21652635 MGI:MGI:5317390 NCBI chr 7:23,815,246...23,843,505
Ensembl chr 7:23,815,245...23,843,634
JBrowse link
G Fhl1 four and a half LIM domains 1 ISO
IEA
(PMID:21702045)
GO_REF:0000107
RGD
Ensembl
PMID:21702045 GO_REF:0000107 NCBI chr  X:159,112,516...159,172,528
Ensembl chr  X:159,112,880...159,172,524
JBrowse link
G Gjc2 gap junction protein, gamma 2 IMP RGD PMID:28278052 RGD:13208599 NCBI chr10:45,526,740...45,535,520
Ensembl chr10:45,526,745...45,534,570
JBrowse link
G Gpnmb glycoprotein nmb ISO (PMID:19350579) RGD PMID:19350579 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Haspin histone H3 associated protein kinase ISO (MGI:MGI:1338645|PMID:10358056) RGD PMID:10358056 MGI:MGI:1338645 NCBI chr10:59,695,403...59,698,398
Ensembl chr10:59,695,913...59,698,168
JBrowse link
G Jade1 jade family PHD finger 1 ISO (PMID:23001567) RGD PMID:23001567 NCBI chr 2:128,461,147...128,514,298
Ensembl chr 2:128,461,224...128,514,291
JBrowse link
G Kank2 KN motif and ankyrin repeat domains 2 ISO
IBA
(PMID:17476305)
PMID:21873635
RGD PMID:17476305, PMID:21873635 RGD:13792537 NCBI chr 8:22,792,000...22,821,459
Ensembl chr 8:22,791,995...22,821,397
JBrowse link
G Klf4 Kruppel like factor 4 ISO (PMID:23867820) RGD PMID:23867820 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Mir26a microRNA 26a ISO (MGI:MGI:5494382|PMID:22210897) RGD PMID:22210897 MGI:MGI:5494382 NCBI chr 8:127,714,441...127,714,530
Ensembl chr 8:127,714,441...127,714,530
JBrowse link
G Mir26b microRNA 26b ISO (MGI:MGI:5494382|PMID:22210897) RGD PMID:22210897 MGI:MGI:5494382 NCBI chr 9:81,675,275...81,675,359
Ensembl chr 9:81,675,275...81,675,359
JBrowse link
G Myo16 myosin XVI IDA
IBA
PMID:17029291
PMID:21873635
BHF-UCL
GO_Central
PMID:17029291, PMID:21873635 RGD:8554212, RGD:13792537 NCBI chr16:84,575,149...85,177,834
Ensembl chr16:84,575,150...84,939,323
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (PMID:16311606) RGD PMID:16311606 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Ppp2r3b protein phosphatase 2, regulatory subunit B'', beta ISO (MGI:MGI:1329724|PMID:9927208) RGD PMID:9927208 MGI:MGI:1329724 NCBI chr14:1,469,748...1,476,353
Ensembl chr14:1,469,748...1,476,355
JBrowse link
G Prmt2 protein arginine methyltransferase 2 ISO (MGI:MGI:3653799|PMID:16616919) RGD PMID:16616919 MGI:MGI:3653799 NCBI chr20:13,154,513...13,212,613
Ensembl chr20:13,156,241...13,212,606
JBrowse link
G Pten phosphatase and tensin homolog ISO (PMID:21241890) RGD PMID:21241890 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO
IBA
IEA
MGI:MGI:1857339 (MGI:MGI:3664376|PMID:7958874)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:7958874, PMID:21873635 GO_REF:0000107, MGI:MGI:3664376, RGD:13792537 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO (MGI:MGI:6271967|PMID:30321469) RGD PMID:30321469 MGI:MGI:6271967 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Slfn13 schlafen family member 13 ISO (PMID:22927417) RGD PMID:22927417 NCBI chr10:70,326,157...70,343,024
Ensembl chr10:70,326,157...70,342,492
JBrowse link
G Zc3h12d zinc finger CCCH type containing 12D ISO (PMID:19531561) RGD PMID:19531561 NCBI chr 1:1,937,620...1,972,919
Ensembl chr 1:1,938,419...1,972,918
JBrowse link
G Zfp655 zinc finger protein 655 ISO
ISS
(PMID:15558030)
GO_REF:0000024
RGD
UniProt
PMID:15558030 GO_REF:0000024 NCBI chr12:11,122,779...11,146,182
Ensembl chr12:11,127,754...11,144,754
JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:15149599) RGD PMID:15149599 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain ISO
IBA
(PMID:21726810)
PMID:21873635
RGD PMID:21726810, PMID:21873635 RGD:13792537 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Pidd1 p53-induced death domain protein 1 ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:MGI:3580934 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Rbm38 RNA binding motif protein 38 ISO (PMID:17050675) RGD PMID:17050675 NCBI chr 3:171,037,891...171,050,500
Ensembl chr 3:171,037,957...171,050,475
JBrowse link
G Rpl26 ribosomal protein L26 ISO (PMID:16213212)
(MGI:MGI:5882892|PMID:16213212)
RGD PMID:16213212 MGI:MGI:5882892 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Sox4 SRY-box transcription factor 4 ISO (PMID:19234109) RGD PMID:19234109 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Tp53 tumor protein p53 ISO MGI:MGI:108027 (MGI:MGI:3589512|PMID:16107883)
(PMID:16213212)
RGD PMID:16107883, PMID:16213212 MGI:MGI:3589512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
mitotic G1 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 ISO
ISS
(PMID:19412162)
GO_REF:0000024
RGD
UniProt
PMID:19412162 GO_REF:0000024 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Dgkz diacylglycerol kinase zeta ISO UniProtKB:P06400 (PMID:16286473) RGD PMID:16286473 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Fbxo31 F-box protein 31 IEA
ISS
ISO
GO_REF:0000002
GO_REF:0000024
(PMID:19412162)
InterPro
UniProt
RGD
PMID:19412162 GO_REF:0000002, GO_REF:0000024 NCBI chr19:53,487,610...53,625,673
Ensembl chr19:53,487,613...53,625,673
JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 ISO MGI:MGI:4126459 (MGI:MGI:4366664|PMID:19744960) RGD PMID:19744960 MGI:MGI:4366664 NCBI chr 9:94,425,191...94,550,431
Ensembl chr 9:94,425,252...94,550,431
JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 ISO (PMID:20173098) RGD PMID:20173098 NCBI chr19:42,960,597...42,971,894
Ensembl chr19:42,964,586...42,972,101
JBrowse link
G Rpa2 replication protein A2 ISO (PMID:21731742) RGD PMID:21731742 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rps27l ribosomal protein S27-like ISO (PMID:18056458) RGD PMID:18056458 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:7958916)
(MGI:MGI:3589512|PMID:16107883)
RGD PMID:7958916, PMID:16107883 MGI:MGI:3589512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
mitotic G1/S transition checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 ISO
IBA
ISS
(MGI:MGI:5142362|PMID:21376736)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21376736, PMID:21873635 GO_REF:0000024, MGI:MGI:5142362, RGD:13792537 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Plk5 polo-like kinase 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,212,910...12,234,253
Ensembl chr 7:12,212,911...12,221,330
JBrowse link
negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nacc2 NACC family member 2 ISO
IBA
IEA
(PMID:22926524)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:22926524, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:3,508,084...3,574,787
Ensembl chr 3:3,510,041...3,574,787
JBrowse link
signal transduction involved in mitotic G1 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO (PMID:21731742) RGD PMID:21731742 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cell cycle process 1210
        cell cycle phase transition 431
          mitotic cell cycle phase transition 388
            G1/S transition of mitotic cell cycle 185
              negative regulation of G1/S transition of mitotic cell cycle 61
                G1 cell size control checkpoint + 0
                mitotic G1/S transition checkpoint + 22
                negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter 1
                signal transduction involved in mitotic G1 DNA damage checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          regulation of cell cycle 1021
            regulation of cell cycle process 623
              negative regulation of cell cycle process 226
                negative regulation of cell cycle phase transition 161
                  negative regulation of mitotic cell cycle phase transition 146
                    negative regulation of G1/S transition of mitotic cell cycle 61
                      G1 cell size control checkpoint + 0
                      mitotic G1/S transition checkpoint + 22
                      negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter 1
                      signal transduction involved in mitotic G1 DNA damage checkpoint + 13
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.