ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signaling receptor activity
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Accession:GO:2000272 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.
Synonyms:broad_synonym: negative regulation of receptor activity


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negative regulation of signaling receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:1600115
G Clec12b C-type lectin domain family 12, member B JBrowse link 4 163,140,883 163,157,996 RGD:1624291
RGD:13792537
G Cnrip1 cannabinoid receptor interacting protein 1 JBrowse link 14 100,217,547 100,247,235 RGD:1624291
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:1600115
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 JBrowse link 2 237,148,918 237,240,883 RGD:1600115
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 JBrowse link 1 176,940,424 176,983,076 RGD:1600115
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 JBrowse link 16 74,260,551 74,264,142 RGD:1600115
G Dkkl1 dickkopf like acrosomal protein 1 JBrowse link 1 101,205,426 101,210,675 RGD:1600115
G Dut deoxyuridine triphosphatase JBrowse link 3 117,514,399 117,525,450 RGD:1600115
G Hfe homeostatic iron regulator JBrowse link 17 43,661,276 43,669,327 RGD:1624291
RGD:1600115
G Lrpap1 LDL receptor related protein associated protein 1 JBrowse link 14 80,911,281 80,923,290 RGD:1600115
G Ly6e lymphocyte antigen 6 family member E JBrowse link 7 116,355,426 116,359,862 RGD:1600115
G Ly6g6d lymphocyte antigen 6 family member G6D JBrowse link 20 5,061,849 5,064,768 RGD:1600115
G Ly6h lymphocyte antigen 6 family member H JBrowse link 7 116,605,556 116,608,072 RGD:1600115
G Lynx1 Ly6/neurotoxin 1 JBrowse link 7 115,982,877 115,988,121 RGD:1600115
G Lypd1 Ly6/Plaur domain containing 1 JBrowse link 13 42,219,884 42,263,024 RGD:1600115
G Lypd6 LY6/PLAUR domain containing 6 JBrowse link 3 35,566,956 35,707,416 RGD:1600115
G NEWGENE_1307313 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,895,894 248,898,762 RGD:1600115
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 5 126,031,368 126,053,726 RGD:1600115
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6484258
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:12802358
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 3 79,233,519 79,390,956 RGD:1624291
G Slurp2 secreted LY6/PLAUR domain containing 2 JBrowse link 7 115,977,854 115,981,734 RGD:1600115
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 JBrowse link 10 15,243,429 15,245,757 RGD:1600115
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 JBrowse link 10 81,936,156 81,943,142 RGD:1600115
cross-receptor inhibition within G protein-coupled receptor heterodimer term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calcr calcitonin receptor JBrowse link 4 28,627,439 28,702,559 RGD:1624291
G Ramp3 receptor activity modifying protein 3 JBrowse link 14 86,922,223 86,939,722 RGD:1600115
RGD:1624291
negative regulation of advanced glycation end-product receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:1624291
negative regulation of brain-derived neurotrophic factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fam72a family with sequence similarity 72, member A JBrowse link 13 48,288,071 48,298,604 RGD:8553945
negative regulation of corticotropin-releasing hormone receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crhbp corticotropin releasing hormone binding protein JBrowse link 2 25,141,471 25,153,334 RGD:1600115
RGD:13792537
RGD:1624291
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:13792537
G Cblb Cbl proto-oncogene B JBrowse link 11 51,037,383 51,202,761 RGD:13792537
G Cblc Cbl proto-oncogene C JBrowse link 1 80,699,321 80,716,146 RGD:1624291
RGD:13792537
G Chmp6 charged multivesicular body protein 6 JBrowse link 10 109,073,678 109,079,348 RGD:1624291
RGD:1600115
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:8553726
RGD:1600115
RGD:1624291
G Gprc5a G protein-coupled receptor, class C, group 5, member A JBrowse link 4 168,832,937 168,851,650 RGD:1624291
G Psen1 presenilin 1 JBrowse link 6 107,169,514 107,221,000 RGD:1624291
RGD:1600115
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:1624291
G Socs4 suppressor of cytokine signaling 4 JBrowse link 15 24,056,383 24,070,868 RGD:1624291
RGD:1600115
G Socs5 suppressor of cytokine signaling 5 JBrowse link 6 10,671,311 10,705,610 RGD:1624291
RGD:1600115
G Tsg101 tumor susceptibility 101 JBrowse link 1 102,941,151 102,971,017 RGD:1624291
RGD:1600115
G Vps25 vacuolar protein sorting 25 homolog JBrowse link 10 89,174,684 89,180,165 RGD:1624291
RGD:1600115
G Zfyve28 zinc finger FYVE-type containing 28 JBrowse link 14 81,725,513 81,811,142 RGD:1624291
RGD:13792537
G Zgpat zinc finger CCCH-type and G-patch domain containing JBrowse link 3 176,865,078 176,881,603 RGD:1624291
RGD:1600115
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:13463453

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    biological regulation 12607
      regulation of molecular function 3111
        regulation of signaling receptor activity 534
          negative regulation of signaling receptor activity 46
            cross-receptor inhibition within G protein-coupled receptor heterodimer 2
            negative regulation of AMPA receptor activity 0
            negative regulation of GABA-A receptor activity 0
            negative regulation of NMDA glutamate receptor activity 2
            negative regulation of acetylcholine-gated cation channel activity 0
            negative regulation of advanced glycation end-product receptor activity 1
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of brain-derived neurotrophic factor-activated receptor activity 1
            negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
            negative regulation of corticotropin-releasing hormone receptor activity 1
            negative regulation of epidermal growth factor-activated receptor activity 14
            negative regulation of nerve growth factor receptor activity 0
            negative regulation of osmolarity-sensing cation channel activity 0
            negative regulation of proteinase activated receptor activity 0
Path 2
Term Annotations click to browse term
  biological_process 17896
    biological regulation 12607
      regulation of biological process 11951
        regulation of cellular process 11287
          signal transduction 6515
            regulation of signal transduction 2983
              regulation of signaling receptor activity 534
                negative regulation of signaling receptor activity 46
                  cross-receptor inhibition within G protein-coupled receptor heterodimer 2
                  negative regulation of AMPA receptor activity 0
                  negative regulation of GABA-A receptor activity 0
                  negative regulation of NMDA glutamate receptor activity 2
                  negative regulation of acetylcholine-gated cation channel activity 0
                  negative regulation of advanced glycation end-product receptor activity 1
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of brain-derived neurotrophic factor-activated receptor activity 1
                  negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
                  negative regulation of corticotropin-releasing hormone receptor activity 1
                  negative regulation of epidermal growth factor-activated receptor activity 14
                  negative regulation of nerve growth factor receptor activity 0
                  negative regulation of osmolarity-sensing cation channel activity 0
                  negative regulation of proteinase activated receptor activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.