Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of signaling receptor activity
go back to main search page
Accession:GO:2000272 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.
Synonyms:broad_synonym: negative regulation of receptor activity


show annotations for term's descendants           Sort by:
 
negative regulation of signaling receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Clec12b C-type lectin domain family 12, member B ISO
IBA
(PMID:17562706)
PMID:21873635
RGD PMID:17562706, PMID:21873635 RGD:13792537 NCBI chr 4:163,140,883...163,157,996
Ensembl chr 4:163,141,132...163,157,744
JBrowse link
G Cnrip1 cannabinoid receptor interacting protein 1 ISO
IBA
(PMID:17895407)
PMID:21873635
RGD PMID:17895407, PMID:21873635 RGD:13792537 NCBI chr14:100,217,547...100,247,235
Ensembl chr14:100,217,289...100,247,235
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:237,148,918...237,240,883
Ensembl chr 2:237,148,941...237,241,350
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
JBrowse link
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr16:74,260,551...74,264,142
Ensembl chr16:74,260,551...74,264,142
JBrowse link
G Dkkl1 dickkopf like acrosomal protein 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:101,205,426...101,210,675
Ensembl chr 1:101,205,426...101,210,675
JBrowse link
G Dut deoxyuridine triphosphatase IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:117,514,399...117,525,450
Ensembl chr 3:117,514,444...117,525,446
JBrowse link
G Hfe homeostatic iron regulator ISO (PMID:9465039) RGD PMID:9465039 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G LOC100910656 ly-6/neurotoxin-like protein 1-like IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:116,280,707...116,285,238
Ensembl chr 7:116,275,817...116,284,587
JBrowse link
G LOC100911104 lymphocyte antigen 6B-like IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:22,868,518...22,872,403
Ensembl chr14:22,868,515...22,890,958
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831
JBrowse link
G Ly6c Ly6-C antigen IEA GO_REF:0000108 GOC GO_REF:0000108
G Ly6e lymphocyte antigen 6 family member E IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Ly6g6d lymphocyte antigen 6 family member G6D IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:5,061,849...5,064,768
Ensembl chr20:5,061,658...5,064,469
JBrowse link
G Ly6g6g lymphocyte antigen 6 complex, locus G6G IEA GO_REF:0000108 GOC GO_REF:0000108 Ensembl chr 7:116,003,595...116,010,974 JBrowse link
G Ly6h lymphocyte antigen 6 family member H IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:116,605,556...116,608,072
Ensembl chr 7:116,605,558...116,607,674
JBrowse link
G Ly6i lymphocyte antigen 6 complex, locus I IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:116,419,573...116,425,016
Ensembl chr 7:116,419,578...116,425,003
JBrowse link
G Lynx1 Ly6/neurotoxin 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:115,982,877...115,988,121
Ensembl chr 7:115,982,876...115,988,090
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr13:42,219,884...42,263,024
Ensembl chr13:42,219,887...42,263,024
JBrowse link
G Lypd6 LY6/PLAUR domain containing 6 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:35,566,956...35,707,416
Ensembl chr 3:35,679,750...35,707,410
JBrowse link
G NEWGENE_1307313 dickkopf WNT signaling pathway inhibitor 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:248,895,894...248,898,762
Ensembl chr 1:248,954,244...248,956,446
Ensembl chr 1:248,954,244...248,956,446
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IMP extrasynaptic NMDAR RGD PMID:22593067 RGD:6484258 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Pten phosphatase and tensin homolog IMP GABA A receptors RGD PMID:24044036 RGD:12802358 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO (MGI:MGI:4942251|PMID:12771128) RGD PMID:12771128 MGI:MGI:4942251 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G RGD1565410 similar to Ly6-C antigen gene IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:116,482,867...116,504,853
Ensembl chr 7:116,501,673...116,504,853
JBrowse link
G Slurp2 secreted LY6/PLAUR domain containing 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:115,977,854...115,981,734
Ensembl chr 7:115,977,852...115,981,731
JBrowse link
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:15,243,429...15,245,757
Ensembl chr10:15,243,429...15,245,757
JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:81,936,156...81,943,142
Ensembl chr10:81,936,444...81,942,188
JBrowse link
G Zfp653 zinc finger protein 653 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:23,066,576...23,085,502
Ensembl chr 8:23,066,576...23,084,879
JBrowse link
cross-receptor inhibition within G protein-coupled receptor heterodimer term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor ISO UniProtKB:O60896 (PMID:14722252) RGD PMID:14722252 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Ramp3 receptor activity modifying protein 3 ISO UniProtKB:P30988 (PMID:14722252) RGD PMID:14722252 NCBI chr14:86,922,223...86,939,722
Ensembl chr14:86,922,223...86,939,719
JBrowse link
negative regulation of advanced glycation end-product receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor ISO (MGI:MGI:3692350|PMID:16503878) RGD PMID:16503878 MGI:MGI:3692350 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
negative regulation of brain-derived neurotrophic factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fam72a family with sequence similarity 72, member A IDA PMID:19755123 MGI PMID:19755123 RGD:8553945 NCBI chr13:48,288,071...48,298,604
Ensembl chr13:48,287,873...48,298,664
JBrowse link
negative regulation of corticotropin-releasing hormone receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhbp corticotropin releasing hormone binding protein IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(PMID:18234674)
Ensembl
UniProt
RGD
PMID:18234674, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
JBrowse link
negative regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbl Cbl proto-oncogene IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cblb Cbl proto-oncogene B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:51,037,383...51,202,761
Ensembl chr11:51,037,393...51,202,820
JBrowse link
G Cblc Cbl proto-oncogene C ISO
IBA
(PMID:10362357)
PMID:21873635
RGD PMID:10362357, PMID:21873635 RGD:13792537 NCBI chr 1:80,699,321...80,716,146
Ensembl chr 1:80,699,323...80,716,146
JBrowse link
G Chmp6 charged multivesicular body protein 6 ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:109,073,678...109,079,348
Ensembl chr10:109,073,678...109,079,348
JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 IDA
ISS
ISO
PMID:17599051
GO_REF:0000024
(MGI:MGI:3629275|PMID:16648858)
(PMID:18046415)
UniProt
RGD
PMID:16648858, PMID:18046415, PMID:17599051 GO_REF:0000024, MGI:MGI:3629275, RGD:8553726 NCBI chr 5:167,951,564...167,966,011
Ensembl chr 5:167,952,728...167,966,009
JBrowse link
G Gprc5a G protein-coupled receptor, class C, group 5, member A ISO (MGI:MGI:5635952|PMID:25744720) RGD PMID:25744720 MGI:MGI:5635952 NCBI chr 4:168,832,937...168,851,650
Ensembl chr 4:168,832,910...168,851,652
JBrowse link
G Psen1 presenilin 1 ISO (MGI:MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:MGI:4887523 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
G Psen2 presenilin 2 ISO (MGI:MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:MGI:4887523 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
G Socs4 suppressor of cytokine signaling 4 ISO (PMID:15590694) RGD PMID:15590694 NCBI chr15:24,056,383...24,070,868
Ensembl chr15:24,056,383...24,070,857
JBrowse link
G Socs5 suppressor of cytokine signaling 5 ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:10,671,311...10,705,610
Ensembl chr 6:10,674,371...10,704,977
JBrowse link
G Tsg101 tumor susceptibility 101 ISO (PMID:16973552) RGD PMID:16973552 NCBI chr 1:102,941,151...102,971,017
Ensembl chr 1:102,941,231...102,970,950
JBrowse link
G Vps25 vacuolar protein sorting 25 homolog ISO (PMID:16973552) RGD PMID:16973552 NCBI chr10:89,174,684...89,180,165
Ensembl chr10:89,174,684...89,180,160
JBrowse link
G Zfyve28 zinc finger FYVE-type containing 28 ISO
IBA
(PMID:19460345)
PMID:21873635
RGD PMID:19460345, PMID:21873635 RGD:13792537 NCBI chr14:81,725,513...81,811,142
Ensembl chr14:81,725,513...81,811,142
JBrowse link
G Zgpat zinc finger CCCH-type and G-patch domain containing ISO
ISS
(PMID:19644445)
GO_REF:0000024
RGD
UniProt
PMID:19644445 GO_REF:0000024 NCBI chr 3:176,865,078...176,881,603
Ensembl chr 3:176,865,156...176,881,549
JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 Eph receptor B2 ISO (MGI:MGI:4867584|PMID:21113149) RGD PMID:21113149 MGI:MGI:4867584 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
JBrowse link
G Park7 Parkinsonism associated deglycase IMP RGD PMID:20698836 RGD:13463453 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Slc6a9 solute carrier family 6 member 9 ISO
IEA
(MGI:MGI:3044468|PMID:15159536)
GO_REF:0000107
RGD
Ensembl
PMID:15159536 GO_REF:0000107, MGI:MGI:3044468 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    biological regulation 13767
      regulation of molecular function 3065
        regulation of signaling receptor activity 185
          negative regulation of signaling receptor activity 54
            cross-receptor inhibition within G protein-coupled receptor heterodimer 2
            negative regulation of AMPA receptor activity 0
            negative regulation of GABA-A receptor activity 0
            negative regulation of NMDA glutamate receptor activity 3
            negative regulation of acetylcholine-gated cation channel activity 0
            negative regulation of advanced glycation end-product receptor activity 1
            negative regulation of beta1-adrenergic receptor activity 0
            negative regulation of brain-derived neurotrophic factor-activated receptor activity 1
            negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
            negative regulation of corticotropin-releasing hormone receptor activity 1
            negative regulation of epidermal growth factor-activated receptor activity 14
            negative regulation of nerve growth factor receptor activity 0
            negative regulation of osmolarity-sensing cation channel activity 0
            negative regulation of proteinase activated receptor activity 0
Path 2
Term Annotations click to browse term
  biological_process 20017
    biological regulation 13767
      regulation of biological process 13081
        regulation of cellular process 12570
          signal transduction 7015
            regulation of signal transduction 2997
              regulation of signaling receptor activity 185
                negative regulation of signaling receptor activity 54
                  cross-receptor inhibition within G protein-coupled receptor heterodimer 2
                  negative regulation of AMPA receptor activity 0
                  negative regulation of GABA-A receptor activity 0
                  negative regulation of NMDA glutamate receptor activity 3
                  negative regulation of acetylcholine-gated cation channel activity 0
                  negative regulation of advanced glycation end-product receptor activity 1
                  negative regulation of beta1-adrenergic receptor activity 0
                  negative regulation of brain-derived neurotrophic factor-activated receptor activity 1
                  negative regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
                  negative regulation of corticotropin-releasing hormone receptor activity 1
                  negative regulation of epidermal growth factor-activated receptor activity 14
                  negative regulation of nerve growth factor receptor activity 0
                  negative regulation of osmolarity-sensing cation channel activity 0
                  negative regulation of proteinase activated receptor activity 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.