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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of signaling receptor activity
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Accession:GO:2000273 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of signaling receptor activity.
Synonyms:exact_synonym: positive regulation of signalling receptor activity


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positive regulation of signaling receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist ISO (MGI:4845816|PMID:20660291) RGD PMID:20660291 MGI:4845816 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Hfe homeostatic iron regulator ISO UniProtKB:P02787|UniProtKB:P61769|UniProtKB:Q07891|UniProtKB:Q9UP52 (PMID:18353247) RGD PMID:18353247 NCBI chr17:43,661,276...43,669,327
Ensembl chr17:43,661,222...43,669,985
JBrowse link
G Itgb1 integrin subunit beta 1 ISO
IEA
(PMID:24044949)
GO_REF:0000107
RGD
Ensembl
PMID:24044949 GO_REF:0000107 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Med1 mediator complex subunit 1 ISO (PMID:18391015) RGD PMID:18391015 NCBI chr10:86,101,560...86,145,271
Ensembl chr10:86,103,600...86,144,880
JBrowse link
G Ncapg2 non-SMC condensin II complex, subunit G2 ISO (MGI:3640711|PMID:16673016) RGD PMID:16673016 MGI:3640711 NCBI chr 6:144,291,313...144,362,454
Ensembl chr 6:144,291,974...144,363,947
JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor ISO (MGI:3640711|PMID:16673016) RGD PMID:16673016 MGI:3640711 NCBI chr 5:133,864,401...133,878,604
Ensembl chr 5:133,864,798...133,878,830
JBrowse link
G Tcf3 transcription factor 3 ISO (MGI:3640711|PMID:16673016) RGD PMID:16673016 MGI:3640711 NCBI chr 7:12,146,642...12,168,400
Ensembl chr 7:12,144,162...12,168,410
JBrowse link
positive regulation of AMPA receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1070 (PMID:20395454)
Ensembl
RGD
PMID:20395454 GO_REF:0000107 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein IMP
IBA
PMID:17088211
PMID:21873635
CACAO
GO_Central
PMID:17088211, PMID:21873635 RGD:10047209, RGD:13792537 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 IDA RGD PMID:16093395 RGD:13515081 NCBI chr 7:119,228,112...119,353,332
Ensembl chr 7:119,228,102...119,352,605
JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 IDA RGD PMID:12771129 RGD:13515082 NCBI chr 1:192,613,766...192,708,371
Ensembl chr 1:192,613,372...192,709,078
JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 IDA RGD PMID:12771129 RGD:13515082 NCBI chr10:95,954,160...96,015,484
Ensembl chr10:95,951,234...96,015,499
JBrowse link
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 IDA RGD PMID:12771129 RGD:13515082 NCBI chr 1:64,330,106...64,350,338
Ensembl chr 1:64,330,106...64,350,338
JBrowse link
G Nlgn3 neuroligin 3 IEA
ISO
ISS
GO_REF:0000107
(MGI:5320268|PMID:21642956)
GO_REF:0000024
Ensembl
RGD
BHF-UCL
PMID:21642956 GO_REF:0000024, GO_REF:0000107, MGI:5320268 NCBI chr  X:71,199,390...71,227,460
Ensembl chr  X:71,199,491...71,222,732
JBrowse link
G Reln reelin IEA
ISO
GO_REF:0000107
(MGI:3765383|PMID:17229826)
Ensembl
RGD
PMID:17229826 GO_REF:0000107, MGI:3765383 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 ISS
ISO
IEA
GO_REF:0000024
(MGI:4948759|PMID:21423165)
GO_REF:0000107
BHF-UCL
RGD
Ensembl
PMID:21423165 GO_REF:0000024, GO_REF:0000107, MGI:4948759 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
positive regulation of epidermal growth factor-activated receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
(PMID:17655843), (PMID:18483258)
GO_REF:0000107
RGD
Ensembl
PMID:17655843, PMID:18483258 GO_REF:0000107 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adora1 adenosine A1 receptor IMP RGD PMID:19574994 RGD:2317913 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:17655843) RGD PMID:17655843 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Areg amphiregulin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Btc betacellulin IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:18,231,854...18,270,621
Ensembl chr14:18,231,860...18,272,484
JBrowse link
G Egf epidermal growth factor ISO (PMID:15611079), (PMID:20353436), (PMID:22732145) RGD PMID:15611079, PMID:20353436, PMID:22732145 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Epgn epithelial mitogen ISO
IBA
ISS
(PMID:15611079)
(MGI:1934957|PMID:11278323)
PMID:21873635
GO_REF:0000024
RGD
HGNC
PMID:11278323, PMID:15611079, PMID:21873635 GO_REF:0000024, MGI:1934957, RGD:13792537 NCBI chr14:18,627,103...18,635,135
Ensembl chr14:18,626,644...18,634,309
JBrowse link
G Ereg epiregulin IDA
IBA
PMID:9990076
PMID:21873635
UniProt
GO_Central
PMID:9990076, PMID:21873635 RGD:632743, RGD:13792537 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO (PMID:20208556) RGD PMID:20208556 NCBI chr 2:184,230,191...184,309,805
Ensembl chr 2:184,231,260...184,309,664
JBrowse link
G Hbegf heparin-binding EGF-like growth factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:29,330,302...29,340,185
Ensembl chr18:29,329,764...29,340,403
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO MGI:2152037 (MGI:2149168|PMID:11481456) RGD PMID:11481456 MGI:2149168 NCBI chr 1:266,953,006...267,038,879
Ensembl chr 1:266,952,561...267,038,883
JBrowse link
G Tgfa transforming growth factor alpha ISO
IBA
ISS
(PMID:11278323)
PMID:21873635
GO_REF:0000024
RGD
HGNC
PMID:11278323, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
positive regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550
G Cfl1 cofilin 1 IMP RGD PMID:24089484 RGD:11570552 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Ephb2 Eph receptor B2 ISO (MGI:4867584|PMID:21113149) RGD PMID:21113149 MGI:4867584 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
JBrowse link
G Ifng interferon gamma IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Ifngr2 interferon gamma receptor 2 IGI PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chr11:31,694,339...31,712,611
Ensembl chr11:31,694,339...31,712,611
JBrowse link
G Pink1 PTEN induced kinase 1 IMP RGD PMID:20698836 RGD:13463453 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Rgs9 regulator of G-protein signaling 9 IDA RGD PMID:16510730 RGD:1599994 NCBI chr10:97,509,971...97,582,188
Ensembl chr10:97,509,971...97,582,188
JBrowse link
receptor transactivation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA
IMP
(PMID:17655843)
GO_REF:0000107
RGD
Ensembl
PMID:17655843, PMID:25232008 GO_REF:0000107, RGD:13703036 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adra2a adrenoceptor alpha 2A ISO (PMID:17215105), (PMID:17655843) RGD PMID:17215105, PMID:17655843 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Adra2b adrenoceptor alpha 2B ISO (PMID:17215105) RGD PMID:17215105 NCBI chr 3:119,805,941...119,809,987
Ensembl chr 3:119,805,941...119,809,987
JBrowse link
G Adra2c adrenoceptor alpha 2C ISO (PMID:17215105) RGD PMID:17215105 NCBI chr14:80,730,307...80,732,010
Ensembl chr14:80,730,307...80,732,010
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of molecular function 3074
        regulation of signaling receptor activity 189
          positive regulation of signaling receptor activity 40
            positive regulation of AMPA receptor activity 9
            positive regulation of G protein-coupled receptor activity in other organism 0
            positive regulation of GABA-A receptor activity 0
            positive regulation of NMDA glutamate receptor activity 9
            positive regulation of advanced glycation end-product receptor activity 0
            positive regulation of beta1-adrenergic receptor activity 0
            positive regulation of brain-derived neurotrophic factor-activated receptor activity 0
            positive regulation of chemorepellent activity 0
            positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
            positive regulation of corticotropin-releasing hormone receptor activity 0
            positive regulation of cytokine activity 0
            positive regulation of epidermal growth factor-activated receptor activity 13
            positive regulation of growth hormone activity 0
            positive regulation of nerve growth factor receptor activity 0
            positive regulation of osmolarity-sensing cation channel activity 0
            positive regulation of proteinase activated receptor activity 0
            receptor transactivation 4
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            regulation of signal transduction 2934
              regulation of signaling receptor activity 189
                positive regulation of signaling receptor activity 40
                  positive regulation of AMPA receptor activity 9
                  positive regulation of G protein-coupled receptor activity in other organism 0
                  positive regulation of GABA-A receptor activity 0
                  positive regulation of NMDA glutamate receptor activity 9
                  positive regulation of advanced glycation end-product receptor activity 0
                  positive regulation of beta1-adrenergic receptor activity 0
                  positive regulation of brain-derived neurotrophic factor-activated receptor activity 0
                  positive regulation of chemorepellent activity 0
                  positive regulation of coreceptor activity involved in epidermal growth factor receptor signaling pathway 0
                  positive regulation of corticotropin-releasing hormone receptor activity 0
                  positive regulation of cytokine activity 0
                  positive regulation of epidermal growth factor-activated receptor activity 13
                  positive regulation of growth hormone activity 0
                  positive regulation of nerve growth factor receptor activity 0
                  positive regulation of osmolarity-sensing cation channel activity 0
                  positive regulation of proteinase activated receptor activity 0
                  receptor transactivation 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.