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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cellular senescence
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Accession:GO:2000772 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cellular senescence.


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regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO MGI:MGI:1338938 (MGI:MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:MGI:5449665 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5554364|PMID:22101268)
Ensembl
UniProt
RGD
PMID:22101268 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5554364 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:MGI:87859 (MGI:MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:MGI:5449665 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISO MGI:MGI:1890508 (MGI:MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:MGI:5500993 NCBI chr 5:169,475,270...169,482,031
Ensembl chr 5:169,475,270...169,482,030
JBrowse link
G Ing2 inhibitor of growth family, member 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:47,714,756...47,725,836
Ensembl chr16:47,717,951...47,725,836
JBrowse link
G Nek4 NIMA-related kinase 4 ISO (PMID:22851694) RGD PMID:22851694 NCBI chr16:7,035,002...7,080,272
Ensembl chr16:7,035,068...7,075,554
JBrowse link
G Nuak1 NUAK family kinase 1 ISO (PMID:19927127) RGD PMID:19927127 NCBI chr 7:25,039,336...25,111,118
Ensembl chr 7:25,039,335...25,113,664
JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 ISO (PMID:16055741) RGD PMID:16055741 NCBI chr14:113,530,470...113,561,645
Ensembl chr14:113,530,470...113,561,645
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 ISO (PMID:18678645) RGD PMID:18678645 NCBI chr10:4,375,329...4,387,195
Ensembl chr10:4,356,915...4,390,030
JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 ISO MGI:MGI:2445449 (MGI:MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:MGI:5913114 NCBI chr  X:146,532,002...146,533,538 JBrowse link
G Tp53 tumor protein p53 ISO MGI:MGI:2139971 (MGI:MGI:5504576|PMID:22904064) RGD PMID:22904064 MGI:MGI:5504576 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vash1 vasohibin 1 ISO (PMID:23056314) RGD PMID:23056314 NCBI chr 6:110,624,377...110,640,942
Ensembl chr 6:110,624,856...110,637,382
JBrowse link
G Zfp277 zinc finger protein 277 ISO MGI:MGI:5496522 (MGI:MGI:5496352|PMID:20808772) RGD PMID:20808772 MGI:MGI:5496352 NCBI chr 6:60,246,209...60,374,388
Ensembl chr 6:60,246,214...60,374,389
JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO MGI:MGI:1888594|MGI:MGI:2180033 (MGI:MGI:3789238|PMID:16079796), (MGI:MGI:5139938|PMID:21746928), (MGI:MGI:5500993|PMID:23686339) RGD PMID:16079796, PMID:21746928, PMID:23686339 MGI:MGI:3789238, MGI:MGI:5139938, MGI:MGI:5500993 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541
JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO MGI:MGI:104738 (MGI:MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:MGI:5449665 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO
IEA
(PMID:25323119)
GO_REF:0000107
RGD
Ensembl
PMID:25323119 GO_REF:0000107 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Bcl2l12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) RGD PMID:20837658 MGI:MGI:4834958 NCBI chr 1:100,984,550...100,993,269
Ensembl chr 1:100,984,550...100,993,269
JBrowse link
G Bcl6 BCL6, transcription repressor ISO MGI:MGI:2158436 (MGI:MGI:5469797|PMID:23209284) RGD PMID:23209284 MGI:MGI:5469797 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Cdk6 cyclin-dependent kinase 6 ISO (PMID:17420273) RGD PMID:17420273 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Fbxo5 F-box protein 5 ISO (PMID:17875940) RGD PMID:17875940 NCBI chr 1:42,461,277...42,467,646
Ensembl chr 1:42,461,291...42,467,586
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO (MGI:MGI:5582375|PMID:23072816) RGD PMID:23072816 MGI:MGI:5582375 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G LOC100912427 nuclease-sensitive element-binding protein 1-like ISO (MGI:MGI:6158172|PMID:29712925) RGD PMID:29712925 MGI:MGI:6158172 NCBI chr 1:186,635,408...186,641,503
Ensembl chr 1:186,640,425...186,641,393
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 ISO (PMID:28640956) RGD PMID:28640956 NCBI chr10:94,280,703...94,349,372
Ensembl chr10:94,280,703...94,349,368
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase IDA RGD PMID:28125705 RGD:13781884 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Plk2 polo-like kinase 2 ISO (MGI:MGI:6120300|PMID:27908889) RGD PMID:27908889 MGI:MGI:6120300 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 ISO (PMID:28595801) RGD PMID:28595801 NCBI chr 3:153,263,692...153,321,351
Ensembl chr 3:153,263,692...153,321,352
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:20203304), (PMID:20424141)
GO_REF:0000107
RGD
Ensembl
PMID:20203304, PMID:20424141 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc30a10 solute carrier family 30, member 10 ISO (PMID:22427991) RGD PMID:22427991 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
G Terf2 telomeric repeat binding factor 2 ISO (PMID:11927518) RGD PMID:11927518 NCBI chr19:39,271,992...39,301,506
Ensembl chr19:39,272,499...39,300,893
JBrowse link
G Tert telomerase reverse transcriptase ISO (PMID:11313459), (PMID:11927518) RGD PMID:11313459, PMID:11927518 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tp63 tumor protein p63 ISO (PMID:19451233) RGD PMID:19451233 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Twist1 twist family bHLH transcription factor 1 ISO (PMID:17690110) RGD PMID:17690110 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214
JBrowse link
G Ybx1 Y box binding protein 1 ISS
IEA
GO_REF:0000024
GO_REF:0000107
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link
G Zkscan3 zinc finger with KRAB and SCAN domains 3 ISO (PMID:23434374) RGD PMID:23434374 NCBI chr17:45,247,724...45,263,422
Ensembl chr17:45,247,776...45,263,418
JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 IEA
ISO
GO_REF:0000107
(PMID:22928666)
Ensembl
RGD
PMID:22928666 GO_REF:0000107 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G B2m beta-2 microglobulin ISO (PMID:28213472) RGD PMID:28213472 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO (PMID:16901784) RGD PMID:16901784 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cgas cyclic GMP-AMP synthase ISO (MGI:MGI:5909142|PMID:28759028) RGD PMID:28759028 MGI:MGI:5909142 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433
JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 ISO (PMID:25465621) RGD PMID:25465621 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161
JBrowse link
G Hmga1 high mobility group AT-hook 1 ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr20:7,132,501...7,140,155
Ensembl chr20:7,136,007...7,138,980
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:16901784)
GO_REF:0000024
RGD
UniProt
PMID:16901784 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Kras KRAS proto-oncogene, GTPase IMP RGD PMID:17706954 RGD:11060281 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO
IEA
(MGI:MGI:5648604|PMID:25472717)
GO_REF:0000107
RGD
Ensembl
PMID:25472717 GO_REF:0000107, MGI:MGI:5648604 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Sirt1 sirtuin 1 ISO
IEA
(PMID:18687677)
GO_REF:0000107
RGD
Ensembl
PMID:18687677 GO_REF:0000107 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Stk11 serine/threonine kinase 11 ISO (PMID:20203304) RGD PMID:20203304 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Ypel3 yippee-like 3 ISO (PMID:20388804) RGD PMID:20388804 NCBI chr 1:198,210,525...198,213,821
Ensembl chr 1:198,210,525...198,213,816
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      regulation of cellular process 12560
        regulation of cell aging 51
          regulation of cellular senescence 44
            negative regulation of cellular senescence 21
            positive regulation of cellular senescence 12
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of response to stimulus 4096
          regulation of response to stress 1401
            regulation of cellular response to stress 728
              regulation of cellular senescence 44
                negative regulation of cellular senescence 21
                positive regulation of cellular senescence 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.