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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of mitotic sister chromatid separation
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Accession:GO:2000816 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation.
Synonyms:exact_synonym: negative regulation of mitotic sister chromatid resolution;   negative regulation of sister chromatid separation during mitosis
 related_synonym: negative regulation of chromosome separation during mitosis;   negative regulation of mitotic chromosome separation


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negative regulation of mitotic sister chromatid separation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTTG1 PTTG1 regulator of sister chromatid separation, securin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:63,104,698...63,112,382 JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chr 6:893,377...897,706 JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway IEA Ensembl GO_REF:0000107 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,912
JBrowse link
G ATM ATM serine/threonine kinase ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,554
JBrowse link
G AURKB aurora kinase B IEA InterPro GO_REF:0000002 NCBI chr12:53,410,833...53,426,165
Ensembl chr12:53,410,176...53,423,225
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISS UniProt GO_REF:0000024 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,237...3,755,188
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 3:45,585,188...45,623,240
Ensembl chr 3:45,585,226...45,624,543
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 1:131,093,026...131,143,840 JBrowse link
G BUB3 BUB3 mitotic checkpoint protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:132,703,088...132,715,353
Ensembl chr14:132,703,704...132,832,574
JBrowse link
G CENPE centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) UniProtKB PMID:12925705 MGI:MGI:2673075 NCBI chr 8:117,888,968...117,965,325
Ensembl chr 8:117,889,009...117,965,792
JBrowse link
G IK IK cytokine IEA Ensembl GO_REF:0000107 NCBI chr 2:142,361,134...142,376,335
Ensembl chr 2:142,361,155...142,378,745
JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member ISO (MGI:MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:MGI:3844372 NCBI chr 1:52,996,706...52,999,074 JBrowse link
G KLHL22 kelch like family member 22 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:50,773,917...50,809,991 JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 IEA
IBA
(PMID:21873635) InterPro
Ensembl
GO_Central
PMID:21873635 GO_REF:0000002, GO_REF:0000107 NCBI chr 3:1,236,066...1,559,346
Ensembl chr 3:1,236,066...1,559,041
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:103,927,358...103,936,669
Ensembl chr 8:103,927,353...103,936,664
JBrowse link
G PLK1 polo like kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 3:22,537,814...22,550,901
Ensembl chr 3:22,537,816...22,555,023
JBrowse link
G PRODH2 proline dehydrogenase 2 IEA InterPro GO_REF:0000002 NCBI chr 6:45,213,712...45,240,437 JBrowse link
G PSMG2 proteasome assembly chaperone 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:96,879,009...96,893,551
Ensembl chr 6:96,878,139...96,893,474
JBrowse link
G SPDL1 spindle apparatus coiled-coil protein 1 IEA InterPro GO_REF:0000002 NCBI chr16:54,276,943...54,303,465
Ensembl chr16:54,254,227...54,303,544
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:34,815,472...34,975,901
Ensembl chr12:34,815,475...34,912,766
JBrowse link
G TPR translocated promoter region, nuclear basket protein IEA Ensembl GO_REF:0000107 NCBI chr 9:127,481,678...127,540,393
Ensembl chr 9:127,481,684...127,540,790
JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr16:79,458,843...79,473,705
Ensembl chr16:79,458,847...79,473,712
JBrowse link
G TTK TTK protein kinase IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:86,076,576...86,125,334
Ensembl chr 1:86,076,583...86,125,718
JBrowse link
G ZNF207 zinc finger protein 207 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:42,576,534...42,602,789
Ensembl chr12:42,571,406...42,612,396
JBrowse link
G ZW10 zw10 kinetochore protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:41,358,801...41,400,254
Ensembl chr 9:41,345,682...41,400,304
JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO5 F-box protein 5 IEA Ensembl GO_REF:0000107 NCBI chr 1:13,466,961...13,478,496
Ensembl chr 1:13,467,501...13,505,936
JBrowse link
G RAD21 RAD21 cohesin complex component IEA Ensembl GO_REF:0000107 NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,888...21,809,435
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 IEA Ensembl GO_REF:0000107 NCBI chr13:18,507,710...18,558,057
Ensembl chr13:18,506,194...18,558,007
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease IEA Ensembl GO_REF:0000107 NCBI chr 3:120,067,792...120,097,305
Ensembl chr 3:120,065,973...120,097,069
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 IEA Ensembl GO_REF:0000107 NCBI chr 8:103,927,358...103,936,669
Ensembl chr 8:103,927,353...103,936,664
JBrowse link
G NDC80 NDC80 kinetochore complex component IEA Ensembl GO_REF:0000107 NCBI chr 6:104,000,794...104,055,785
Ensembl chr 6:103,998,698...104,055,762
JBrowse link
G PCID2 PCI domain containing 2 IEA Ensembl GO_REF:0000107 NCBI chr11:78,541,278...78,556,784
Ensembl chr11:78,541,318...78,556,733
JBrowse link
G TPR translocated promoter region, nuclear basket protein IEA Ensembl GO_REF:0000107 NCBI chr 9:127,481,678...127,540,393
Ensembl chr 9:127,481,684...127,540,790
JBrowse link
G XRCC3 X-ray repair cross complementing 3 IEA Ensembl GO_REF:0000107
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 IEA InterPro GO_REF:0000002 NCBI chr 9:6,685,934...6,689,913
Ensembl chr 9:6,685,936...6,689,256
JBrowse link
G CCNB1 cyclin B1 IEA Ensembl GO_REF:0000107 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,381
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr 1:260,465,809...260,648,070
Ensembl chr 1:260,467,159...260,635,443
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chr 3:21,548,349...21,593,667 JBrowse link
G USP44 ubiquitin specific peptidase 44 IEA Ensembl GO_REF:0000107 NCBI chr 5:87,864,410...87,890,913
Ensembl chr 5:87,875,851...87,889,684
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    cellular process 15777
      chromosome segregation 317
        chromosome separation 90
          mitotic sister chromatid separation 59
            negative regulation of mitotic sister chromatid separation 37
              negative regulation of mitotic metaphase/anaphase transition + 36
              negative regulation of mitotic sister chromatid arm separation 0
Path 2
Term Annotations click to browse term
  biological_process 16545
    cellular process 15777
      cellular component organization or biogenesis 5990
        cellular component organization 5822
          organelle organization 3675
            organelle fission 480
              nuclear division 425
                mitotic nuclear division 271
                  mitotic sister chromatid segregation 152
                    regulation of mitotic sister chromatid segregation 40
                      negative regulation of mitotic sister chromatid segregation 37
                        negative regulation of mitotic sister chromatid separation 37
                          negative regulation of mitotic metaphase/anaphase transition + 36
                          negative regulation of mitotic sister chromatid arm separation 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.