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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of intrinsic apoptotic signaling pathway
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Accession:GO:2001244 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of intrinsic apoptotic signaling pathway.
Synonyms:exact_synonym: positive regulation of intrinsic apoptotic pathway;   positive regulation of intrinsic apoptotic signalling pathway;   positive regulation of mitochondrial-mediated apoptotic pathway
 narrow_synonym: positive regulation of intrinsic apoptosis


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positive regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAD BCL2 associated agonist of cell death JBrowse link 11 62,971,808 62,986,304 RGD:9068941
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 54,793,594 54,800,466 RGD:9068941
G BBC3 BCL2 binding component 3 JBrowse link 19 52,727,826 52,738,535 RGD:9068941
G BCAP31 B cell receptor associated protein 31 JBrowse link X 153,137,992 153,161,628 RGD:9068941
G BCL2 BCL2 apoptosis regulator JBrowse link 18 59,797,184 59,993,298 RGD:9068941
G BCL2L1 BCL2 like 1 JBrowse link 20 29,088,055 29,147,066 RGD:9068941
G BCL2L11 BCL2 like 11 JBrowse link 2A 112,337,927 112,385,079 RGD:9068941
G BCLAF1 BCL2 associated transcription factor 1 JBrowse link 6 138,111,309 138,144,098 RGD:9068941
G BECN1 beclin 1 JBrowse link 17 14,719,781 14,733,286 RGD:9068941
G BID BH3 interacting domain death agonist JBrowse link 22 16,594,186 16,633,695 RGD:9068941
G BMF Bcl2 modifying factor JBrowse link 15 37,281,655 37,302,365 RGD:9068941
G BOK BCL2 family apoptosis regulator BOK JBrowse link 2B 247,626,494 247,640,238 RGD:9068941
G CAV1 caveolin 1 JBrowse link 7 121,193,678 121,229,655 RGD:9068941
G CLU clusterin JBrowse link 8 24,070,053 24,086,934 RGD:9068941
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 31,664,766 31,668,699 RGD:9068941
G DNM1L dynamin 1 like JBrowse link 12 56,077,504 56,142,376 RGD:9068941
G FIS1 fission, mitochondrial 1 JBrowse link 7 106,621,211 106,626,612 RGD:9068941
G FLCN folliculin JBrowse link 17 38,988,520 39,013,189 RGD:9068941
G GSDME gasdermin E JBrowse link 7 24,977,838 25,039,525 RGD:9068941
G IL20RA interleukin 20 receptor subunit alpha JBrowse link 6 138,849,153 138,893,123 RGD:9068941
G LCK LCK proto-oncogene, Src family tyrosine kinase JBrowse link 1 32,567,712 32,579,923 RGD:9068941
G NKX3-1 NK3 homeobox 1 JBrowse link 8 19,860,748 19,864,968 RGD:9068941
G NUPR1 nuclear protein 1, transcriptional regulator JBrowse link 16 29,015,155 29,016,987 RGD:9068941
G PLAGL2 PLAG1 like zinc finger 2 JBrowse link 20 29,610,196 29,625,442 RGD:9068941
G PLEKHF1 pleckstrin homology and FYVE domain containing 1 JBrowse link 19 35,354,315 35,364,366 RGD:9068941
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 56,611,098 56,615,449 RGD:9068941
G PRKRA protein activator of interferon induced protein kinase EIF2AK2 JBrowse link 2B 183,393,819 183,413,174 RGD:9068941
G RACK1 receptor for activated C kinase 1 JBrowse link 5 183,712,665 183,720,128 RGD:9068941
G RIPK3 receptor interacting serine/threonine kinase 3 JBrowse link 14 23,235,796 23,239,821 RGD:9068941
G S100A8 S100 calcium binding protein A8 JBrowse link 1 132,370,435 132,371,591 RGD:9068941
G S100A9 S100 calcium binding protein A9 JBrowse link 1 132,338,246 132,341,497 RGD:9068941
G SIAH1 siah E3 ubiquitin protein ligase 1 JBrowse link 16 47,517,587 47,542,447 RGD:9068941
G SLC9A3R1 SLC9A3 regulator 1 JBrowse link 17 74,250,406 74,271,234 RGD:9068941
G STYXL1 serine/threonine/tyrosine interacting like 1 JBrowse link 7 82,446,382 82,497,773 RGD:9068941
G TAF6 TATA-box binding protein associated factor 6 JBrowse link 7 105,575,861 105,588,177 RGD:9068941
G TP53 tumor protein p53 JBrowse link 17 7,687,132 7,706,120 RGD:9068941
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BBC3 BCL2 binding component 3 JBrowse link 19 52,727,826 52,738,535 RGD:9068941
G BCL2L11 BCL2 like 11 JBrowse link 2A 112,337,927 112,385,079 RGD:9068941
G BOK BCL2 family apoptosis regulator BOK JBrowse link 2B 247,626,494 247,640,238 RGD:9068941
G DDIT3 DNA damage inducible transcript 3 JBrowse link 12 31,664,766 31,668,699 RGD:9068941
G NCK1 NCK adaptor protein 1 JBrowse link 3 141,362,407 141,451,444 RGD:9068941
G NCK2 NCK adaptor protein 2 JBrowse link 2A 106,827,621 106,976,362 RGD:9068941
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 56,611,098 56,615,449 RGD:9068941
G PTPN2 protein tyrosine phosphatase non-receptor type 2 JBrowse link 18 16,562,044 16,659,570 RGD:9068941
G RNF183 ring finger protein 183 JBrowse link 9 112,769,343 112,775,493 RGD:9068941
G SERINC3 serine incorporator 3 JBrowse link 20 41,920,415 41,946,287 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 66,681,983 66,714,065 RGD:9068941
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MSX1 msh homeobox 1 JBrowse link 4 4,935,603 4,939,117 RGD:9068941
G RPL11 ribosomal protein L11 JBrowse link 1 23,868,700 23,873,313 RGD:9068941
G RPS7 ribosomal protein S7 JBrowse link 2A 3,511,821 3,517,785 RGD:9068941
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FBH1 F-box DNA helicase 1 JBrowse link 10 5,915,696 5,962,778 RGD:9068941
G NACC2 NACC family member 2 JBrowse link 9 136,061,365 136,106,911 RGD:9068941
G PIAS4 protein inhibitor of activated STAT 4 JBrowse link 19 3,983,200 4,012,686 RGD:9068941
G RAD9A RAD9 checkpoint clamp component A JBrowse link 11 65,989,692 66,068,220 RGD:9068941
G RPS3 ribosomal protein S3 JBrowse link 11 73,762,794 73,768,982 RGD:9068941
G SKIL SKI like proto-oncogene JBrowse link 3 175,562,001 175,600,181 RGD:9068941
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RPL26 ribosomal protein L26 JBrowse link 17 48,008,951 48,015,977 RGD:9068941
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G BAD BCL2 associated agonist of cell death JBrowse link 11 62,971,808 62,986,304 RGD:9068941
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G NOX1 NADPH oxidase 1 JBrowse link X 100,182,881 100,215,192 RGD:9068941
G PARK7 Parkinsonism associated deglycase JBrowse link 1 7,969,265 7,993,271 RGD:9068941
G SFPQ splicing factor proline and glutamine rich JBrowse link 1 35,624,862 35,641,551 RGD:9068941
G SOD1 superoxide dismutase 1 JBrowse link 21 31,411,702 31,419,432 RGD:9068941
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G FBXW7 F-box and WD repeat domain containing 7 JBrowse link 4 156,312,274 156,527,649 RGD:9068941
G MCL1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 1 129,566,827 129,572,086 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15679
    cellular process 14372
      signal transduction 5557
        intracellular signal transduction 2720
          intrinsic apoptotic signaling pathway 279
            positive regulation of intrinsic apoptotic signaling pathway 58
              positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 11
              positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 4
              positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 7
              positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 1
              positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 0
              positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 6
Path 2
Term Annotations click to browse term
  biological_process 15679
    biological regulation 11191
      regulation of biological process 10596
        positive regulation of biological process 5847
          positive regulation of cellular process 5172
            positive regulation of cell death 681
              positive regulation of programmed cell death 634
                positive regulation of apoptotic process 628
                  positive regulation of apoptotic signaling pathway 173
                    positive regulation of intrinsic apoptotic signaling pathway 58
                      positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 11
                      positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 4
                      positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage + 7
                      positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 1
                      positive regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway 0
                      positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.