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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cation channel activity
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Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


show annotations for term's descendants           Sort by:
 
negative regulation of cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IDA RGD PMID:20624795 RGD:6849299 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Epo erythropoietin ISO (PMID:14569084) RGD PMID:14569084 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Fgf12 fibroblast growth factor 12 IDA RGD PMID:12401812 RGD:6484231 NCBI chr11:75,606,360...76,171,078
Ensembl chr11:75,905,443...76,168,989
JBrowse link
G Mmp9 matrix metallopeptidase 9 IEA
ISO
GO_REF:0000107
(PMID:24164424)
Ensembl
RGD
PMID:24164424 GO_REF:0000107 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stoml1 stomatin like 1 ISO (MGI:MGI:5619720|PMID:24247984) RGD PMID:24247984 MGI:MGI:5619720 NCBI chr 8:63,037,135...63,045,024
Ensembl chr 8:63,036,976...63,045,030
JBrowse link
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 ISO
ISS
(MGI:MGI:5613458|PMID:23903368)
GO_REF:0000024
RGD
UniProt
PMID:23903368 GO_REF:0000024, MGI:MGI:5613458 NCBI chr20:19,948,767...20,480,628
Ensembl chr20:20,105,047...20,480,623
JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 IDA
IBA
IMP
PMID:21873635 RGD
GO_Central
PMID:8183366, PMID:21873635, PMID:8799886 RGD:61642, RGD:13792537, RGD:9743956 NCBI chr 2:155,555,798...156,011,438
Ensembl chr 2:155,718,359...156,009,526
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 IDA
IBA
ISO
PMID:19219384
PMID:21873635
(PMID:19219384)
RGD PMID:19219384, PMID:19219384, PMID:21873635 RGD:7243947, RGD:13792537 NCBI chr11:32,498,260...32,511,202
Ensembl chr11:32,498,261...32,508,420
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 IDA
IBA
ISO
PMID:19219384
PMID:21873635
(PMID:19219384)
RGD PMID:19219384, PMID:19219384, PMID:21873635 RGD:7243947, RGD:13792537 NCBI chr11:32,434,786...32,447,264
Ensembl chr11:32,440,237...32,447,259
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 IDA
IBA
ISO
PMID:12954870
PMID:21873635
(PMID:12954870)
RGD PMID:12954870, PMID:12954870, PMID:21873635 RGD:10047250, RGD:13792537 NCBI chr 1:165,189,934...165,196,949
Ensembl chr 1:165,189,985...165,196,948
JBrowse link
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:84,688,873...84,693,066
Ensembl chr 9:84,689,150...84,690,338
JBrowse link
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:113,583,844...113,584,459
Ensembl chr  X:113,583,844...113,584,459
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO (PMID:9305853) RGD PMID:9305853 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link
G Kcnrg potassium channel regulator ISO
IBA
(PMID:19968958)
PMID:21873635
RGD PMID:19968958, PMID:21873635 RGD:13792537 NCBI chr15:41,937,880...41,942,205
Ensembl chr15:41,937,880...41,942,205
JBrowse link
G Mtnr1b melatonin receptor 1B IDA RGD PMID:14962062 RGD:9588668 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 ISO
ISS
(PMID:19223394)
GO_REF:0000024
RGD
UniProt
PMID:19223394 GO_REF:0000024 NCBI chr 9:66,453,428...66,483,614
Ensembl chr 9:66,453,438...66,483,614
JBrowse link
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 ISO
ISS
IEA
(PMID:31454269)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31454269 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISO
ISS
IEA
(PMID:31454269)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31454269 GO_REF:0000024, GO_REF:0000107 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO
ISS
IEA
(PMID:31454269)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:31454269 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Dysf dysferlin ISO MGI:MGI:3055150 (MGI:MGI:5545678|PMID:24302765) RGD PMID:24302765 MGI:MGI:5545678 NCBI chr 4:115,700,942...115,901,873
Ensembl chr 4:115,712,850...115,901,873
JBrowse link
G Rem1 RRAD and GEM like GTPase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:148,108,500...148,116,992
Ensembl chr 3:148,108,539...148,116,991
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002, GO_REF:0000104 NCBI chr19:561,696...564,929
Ensembl chr19:561,727...564,930
JBrowse link
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1 IEA
ISO
GO_REF:0000107
(PMID:18923542)
Ensembl
RGD
PMID:18923542 GO_REF:0000107 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Snx27 sorting nexin 27 IDA RGD PMID:21422294 RGD:8554349 NCBI chr 2:195,738,613...195,821,608
Ensembl chr 2:195,738,619...195,821,608
JBrowse link
negative regulation of large conductance calcium-activated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crbn cereblon ISO (MGI:MGI:6150698|PMID:29530986) RGD PMID:29530986 MGI:MGI:6150698 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556
JBrowse link
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephb2 Eph receptor B2 ISO (MGI:MGI:4867584|PMID:21113149) RGD PMID:21113149 MGI:MGI:4867584 NCBI chr 5:155,024,478...155,143,539
Ensembl chr 5:155,022,493...155,204,456
JBrowse link
G Park7 Parkinsonism associated deglycase IMP RGD PMID:20698836 RGD:13463453 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Slc6a9 solute carrier family 6 member 9 ISO (MGI:MGI:3044468|PMID:15159536) RGD PMID:15159536 MGI:MGI:3044468 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISS
ISO
GO_REF:0000024
(PMID:26164367)
UniProt
RGD
PMID:26164367 GO_REF:0000024 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO
ISS
(PMID:26164367)
GO_REF:0000024
RGD
UniProt
PMID:26164367 GO_REF:0000024 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Casq2 calsequestrin 2 ISO
IEA
IMP
(PMID:16601229)
(PMID:15041652)
GO_REF:0000107
PMID:17569730
RGD
Ensembl
PMID:15041652, PMID:16601229, PMID:17569730 GO_REF:0000107, RGD:2314601 NCBI chr 2:204,512,361...204,568,643
Ensembl chr 2:204,512,302...204,568,656
JBrowse link
G Clic2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) RGD PMID:15147738, PMID:15916532 NCBI chr20:295,338...310,363
Ensembl chr20:295,250...310,380
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:12443530) RGD PMID:12443530 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Gstm2 glutathione S-transferase mu 2 ISO
IEA
(PMID:17023043), (PMID:22406107)
GO_REF:0000107
RGD
Ensembl
PMID:17023043, PMID:22406107 GO_REF:0000107 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO
IEA
(PMID:11035031)
GO_REF:0000107
RGD
Ensembl
PMID:11035031 GO_REF:0000107 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) RGD PMID:17404231 MGI:MGI:3708075 NCBI chr14:6,602,004...6,645,257
Ensembl chr14:6,602,004...6,645,257
JBrowse link
G Sri sorcin ISO (PMID:17699613) RGD PMID:17699613 NCBI chr 4:23,004,657...23,029,233
Ensembl chr 4:23,006,243...23,018,983
JBrowse link
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ubqln1 ubiquilin 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23307288)
Ensembl
UniProt
RGD
PMID:23307288 GO_REF:0000024, GO_REF:0000107 NCBI chr17:6,840,441...6,878,842
Ensembl chr17:6,840,463...6,878,844
JBrowse link
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cabp1 calcium binding protein 1 IDA RGD PMID:17960496 RGD:7207144 NCBI chr12:47,185,449...47,209,785
Ensembl chr12:47,179,664...47,209,784
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F ISO (PMID:27226626) RGD PMID:27226626 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IDA RGD PMID:15024042 RGD:13514097 NCBI chr 7:140,311,120...140,324,902
Ensembl chr 7:140,315,368...140,324,902
JBrowse link
G Cbarp CACN subunit beta associated regulatory protein IMP
IBA
ISO
PMID:21873635
(MGI:MGI:5607190|PMID:24751537)
RGD PMID:24751537, PMID:24751537, PMID:21873635 MGI:MGI:5607190, RGD:10047103, RGD:13792537 NCBI chr 7:12,433,422...12,441,048
Ensembl chr 7:12,433,933...12,441,048
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO (PMID:18292205) RGD PMID:18292205 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Drd2 dopamine receptor D2 ISO
IBA
IDA
(PMID:7921596)
PMID:21873635
PMID:2162345
RGD PMID:7921596, PMID:21873635, PMID:2162345 RGD:13792537, RGD:8554169 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 ISO
IEA
(PMID:7921596)
GO_REF:0000107
RGD
Ensembl
PMID:7921596 GO_REF:0000107 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gnb5 G protein subunit beta 5 IEA
ISO
ISS
GO_REF:0000107
(PMID:11007869), (PMID:12606627)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11007869, PMID:12606627 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:82,248,951...82,286,493
Ensembl chr 8:82,257,849...82,285,184
JBrowse link
G Gpr35 G protein-coupled receptor 35 ISO (PMID:17940199) RGD PMID:17940199 NCBI chr 9:100,129,428...100,141,269
Ensembl chr 9:100,137,881...100,138,801
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:15937148 RGD:9835002 NCBI chr 3:177,223,779...177,231,663
Ensembl chr 3:177,225,737...177,231,663
JBrowse link
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 ISO (PMID:10585425) RGD PMID:10585425 NCBI chr 2:155,555,798...156,011,438
Ensembl chr 2:155,718,359...156,009,526
JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 IDA RGD PMID:14679187, PMID:21943416, PMID:21943417 RGD:7243967, RGD:7242916, RGD:12910700 NCBI chr11:32,498,260...32,511,202
Ensembl chr11:32,498,261...32,508,420
JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 IDA RGD PMID:19219384, PMID:21943416, PMID:14679187 RGD:7243947, RGD:7242916, RGD:7243967 NCBI chr11:32,434,786...32,447,264
Ensembl chr11:32,440,237...32,447,259
JBrowse link
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 IDA
ISO
(PMID:22987075) RGD PMID:22987075, PMID:14679187 RGD:7243967 NCBI chr 1:165,189,934...165,196,949
Ensembl chr 1:165,189,985...165,196,948
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO (PMID:9305853) RGD PMID:9305853 NCBI chr 1:216,293,087...216,630,339
Ensembl chr 1:216,293,087...216,630,339
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    negative regulation of biological process 5686
      negative regulation of transport 530
        negative regulation of transporter activity 91
          negative regulation of ion transmembrane transporter activity 82
            negative regulation of cation channel activity 49
              negative regulation of AMPA receptor activity 0
              negative regulation of NMDA glutamate receptor activity 3
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 1
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 12
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 18
              negative regulation of voltage-gated potassium channel activity + 13
              negative regulation of voltage-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of localization 3018
          regulation of transport 1998
            regulation of transmembrane transport 609
              regulation of ion transmembrane transport 509
                regulation of ion transmembrane transporter activity 275
                  regulation of cation channel activity 186
                    negative regulation of cation channel activity 49
                      negative regulation of AMPA receptor activity 0
                      negative regulation of NMDA glutamate receptor activity 3
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 1
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of proton-transporting ATP synthase activity, rotational mechanism 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 12
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 18
                      negative regulation of voltage-gated potassium channel activity + 13
                      negative regulation of voltage-gated sodium channel activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.