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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cation channel activity
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Accession:GO:2001258 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cation channel activity.
Synonyms:exact_synonym: negative regulation of cation diffusion facilitator activity;   negative regulation of nonselective cation channel activity


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negative regulation of cation channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6849299
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:1624291
RGD:1600115
G Fgf12 fibroblast growth factor 12 JBrowse link 11 75,606,360 76,171,078 RGD:6484231
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:1600115
RGD:1624291
negative regulation of acid-sensing ion channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stoml1 stomatin like 1 JBrowse link 8 63,037,135 63,045,024 RGD:1624291
negative regulation of delayed rectifier potassium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ank3 ankyrin 3 JBrowse link 20 19,948,767 20,480,628 RGD:1624291
RGD:1600115
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 JBrowse link 2 155,555,798 156,011,438 RGD:61642
RGD:9743956
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 11 32,498,260 32,511,202 RGD:7243947
RGD:13792537
RGD:1624291
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link 11 32,434,786 32,447,264 RGD:7243947
RGD:13792537
RGD:1624291
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 JBrowse link 1 165,189,934 165,196,949 RGD:10047250
RGD:13792537
RGD:1624291
G Kcne4 potassium voltage-gated channel subfamily E regulatory subunit 4 JBrowse link 9 84,688,873 84,693,066 RGD:13792537
G Kcne5 potassium voltage-gated channel subfamily E regulatory subunit 5 JBrowse link X 113,583,844 113,584,459 RGD:13792537
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 1 216,293,087 216,630,339 RGD:1624291
G Kcnrg potassium channel regulator JBrowse link 15 41,937,880 41,942,205 RGD:1624291
RGD:1600115
G Mtnr1b melatonin receptor 1B JBrowse link 8 14,359,270 14,373,894 RGD:9588668
G Sumo1 small ubiquitin-like modifier 1 JBrowse link 9 66,453,428 66,483,614 RGD:1624291
RGD:1600115
negative regulation of high voltage-gated calcium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dysf dysferlin JBrowse link 4 115,700,942 115,901,873 RGD:1624291
RGD:1600115
G Rem1 RRAD and GEM like GTPase 1 JBrowse link 3 148,108,500 148,116,992 RGD:1600115
G Rem2 RRAD and GEM like GTPase 2 JBrowse link 15 33,121,273 33,125,752 RGD:1600115
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator JBrowse link 19 561,696 564,929 RGD:1600115
negative regulation of inward rectifier potassium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:1600115
RGD:1624291
G Snx27 sorting nexin 27 JBrowse link 2 195,738,613 195,821,608 RGD:8554349
negative regulation of NMDA glutamate receptor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:13463453
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calm1 calmodulin 1 JBrowse link 6 124,217,241 124,225,292 RGD:1624291
RGD:1600115
G Calm2 calmodulin 2 JBrowse link 6 11,067,675 11,080,078 RGD:1600115
RGD:1624291
G Calm3 calmodulin 3 JBrowse link 1 78,844,520 78,851,628 RGD:1624291
RGD:1600115
G Casq2 calsequestrin 2 JBrowse link 2 204,512,361 204,568,643 RGD:1624291
RGD:1600115
RGD:2314601
G Clic2 chloride intracellular channel 2 JBrowse link 20 295,338 310,363 RGD:1624291
RGD:1600115
G Fkbp1a FKBP prolyl isomerase 1A JBrowse link 3 147,042,944 147,062,725 RGD:1624291
G Fkbp1b FKBP prolyl isomerase 1B JBrowse link 6 29,975,863 29,987,252 RGD:1624291
RGD:1600115
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:1624291
G Gsto1 glutathione S-transferase omega 1 JBrowse link 1 267,607,437 267,617,387 RGD:1624291
RGD:1600115
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link 14 6,602,004 6,645,257 RGD:1624291
RGD:1600115
G Sri sorcin JBrowse link 4 23,004,657 23,029,233 RGD:1624291
RGD:1600115
negative regulation of store-operated calcium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1600115
RGD:1624291
negative regulation of voltage-gated calcium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cabp1 calcium binding protein 1 JBrowse link 12 47,185,449 47,209,785 RGD:7207144
G Cacna1f calcium voltage-gated channel subunit alpha1 F JBrowse link X 15,712,709 15,741,135 RGD:1624291
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:13514097
G Cbarp CACN subunit beta associated regulatory protein JBrowse link 7 12,433,422 12,441,048 RGD:10047103
RGD:13792537
RGD:1624291
G Crhr1 corticotropin releasing hormone receptor 1 JBrowse link 10 92,191,473 92,233,662 RGD:1624291
RGD:1600115
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
RGD:13792537
RGD:8554169
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:13792537
G Drd4 dopamine receptor D4 JBrowse link 1 214,278,296 214,282,818 RGD:1624291
RGD:1600115
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:11059581
G Gnb5 G protein subunit beta 5 JBrowse link 8 82,248,951 82,286,493 RGD:1600115
RGD:1624291
G Gpr35 G protein-coupled receptor 35 JBrowse link 9 100,129,428 100,141,269 RGD:1624291
RGD:1600115
G LOC500460 similar to olfactory receptor Olr841 JBrowse link 5 64,614,755 64,615,714 RGD:13792537
G Olr1257 olfactory receptor 1257 JBrowse link 8 42,429,993 42,430,928 RGD:13792537
G Olr1320 olfactory receptor 1320 JBrowse link 8 43,628,182 43,629,120 RGD:13792537
G Olr533 olfactory receptor 533 JBrowse link 3 74,574,075 74,575,010 RGD:13792537
G Olr841 olfactory receptor 841 JBrowse link 5 64,621,407 64,622,359 RGD:13792537
G Oprl1 opioid related nociceptin receptor 1 JBrowse link 3 177,223,779 177,231,663 RGD:9835002
negative regulation of voltage-gated potassium channel activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnab1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 JBrowse link 2 155,555,798 156,011,438 RGD:1624291
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 JBrowse link 11 32,498,260 32,511,202 RGD:7243967
RGD:7242916
RGD:12910700
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 JBrowse link 11 32,434,786 32,447,264 RGD:7243947
RGD:7242916
RGD:7243967
G Kcne3 potassium voltage-gated channel subfamily E regulatory subunit 3 JBrowse link 1 165,189,934 165,196,949 RGD:7243967
RGD:1624291
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 JBrowse link 1 216,293,087 216,630,339 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18007
    negative regulation of biological process 5407
      negative regulation of transport 580
        negative regulation of transporter activity 94
          negative regulation of ion transmembrane transporter activity 85
            negative regulation of cation channel activity 52
              negative regulation of AMPA receptor activity 0
              negative regulation of NMDA glutamate receptor activity 2
              negative regulation of acetylcholine-gated cation channel activity 0
              negative regulation of acid-sensing ion channel activity 1
              negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
              negative regulation of large conductance calcium-activated potassium channel activity 0
              negative regulation of osmolarity-sensing cation channel activity 0
              negative regulation of ryanodine-sensitive calcium-release channel activity 11
              negative regulation of store-operated calcium channel activity 1
              negative regulation of voltage-gated calcium channel activity + 21
              negative regulation of voltage-gated potassium channel activity + 13
              negative regulation of voltage-gated sodium channel activity 0
Path 2
Term Annotations click to browse term
  biological_process 18007
    biological regulation 12698
      regulation of biological process 12030
        regulation of localization 2949
          regulation of transport 2033
            regulation of transmembrane transport 593
              regulation of ion transmembrane transport 496
                regulation of ion transmembrane transporter activity 273
                  regulation of cation channel activity 183
                    negative regulation of cation channel activity 52
                      negative regulation of AMPA receptor activity 0
                      negative regulation of NMDA glutamate receptor activity 2
                      negative regulation of acetylcholine-gated cation channel activity 0
                      negative regulation of acid-sensing ion channel activity 1
                      negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity 0
                      negative regulation of large conductance calcium-activated potassium channel activity 0
                      negative regulation of osmolarity-sensing cation channel activity 0
                      negative regulation of ryanodine-sensitive calcium-release channel activity 11
                      negative regulation of store-operated calcium channel activity 1
                      negative regulation of voltage-gated calcium channel activity + 21
                      negative regulation of voltage-gated potassium channel activity + 13
                      negative regulation of voltage-gated sodium channel activity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.