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ONTOLOGY REPORT - ANNOTATIONS


Term:abnormal homeostasis
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Accession:MP:0001764 term browser browse the term
Definition:anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues
Synonyms:exact_synonym: abnormal homeostatic process;   homeostasis abnormalities


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abnormal amino acid level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:7207891
abnormal body temperature homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cckar cholecystokinin A receptor JBrowse link 14 59,610,939 59,619,786 RGD:1625204
abnormal chloride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11566051
abnormal circulating aspartate transaminase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
abnormal circulating free fatty acids level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:68930
RGD:1600636
abnormal circulating protein level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11566051
abnormal dopamine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:704422
abnormal hemostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:4889487
abnormal interferon level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
abnormal iron homeostasis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:729808
RGD:1580428
abnormal lipid level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:704418
abnormal lipolysis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:619666
albuminuria term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Btg2 BTG anti-proliferation factor 2 JBrowse link 13 50,913,185 50,916,944 RGD:12802368
G Chi3l1 chitinase 3 like 1 JBrowse link 13 51,022,844 51,030,797 RGD:12802369
G Chit1 chitinase 1 JBrowse link 13 50,947,020 50,994,644 RGD:12802369
G Etnk2 ethanolamine kinase 2 JBrowse link 13 50,481,178 50,498,991 RGD:12802369
G Fmod fibromodulin JBrowse link 13 50,874,886 50,885,503 RGD:12802368
G Gpr37l1 G protein-coupled receptor 37-like 1 JBrowse link 13 51,985,698 51,992,547 RGD:12802369
G Ipo9 importin 9 JBrowse link 13 52,203,384 52,256,196 RGD:12802369
G Lgr6 leucine-rich repeat-containing G protein-coupled receptor 6 JBrowse link 13 51,811,904 51,931,193 RGD:12802369
G Mybph myosin binding protein H JBrowse link 13 51,034,228 51,041,903 RGD:12802369
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:12910103
G Optc opticin JBrowse link 13 50,735,509 50,748,908 RGD:12802368
G Plekha6 pleckstrin homology domain containing A6 JBrowse link 13 50,555,454 50,582,236 RGD:12802369
G Prelp proline and arginine rich end leucine rich repeat protein JBrowse link 13 50,749,526 50,773,934 RGD:12802368
G Ptprv protein tyrosine phosphatase, receptor type, V JBrowse link 13 51,935,239 51,956,262 RGD:12802369
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:12802368
G Rnpep arginyl aminopeptidase JBrowse link 13 52,092,863 52,124,006 RGD:12802369
G Sox13 SRY-box transcription factor 13 JBrowse link 13 50,434,702 50,479,118 RGD:12802369
G Syt2 synaptotagmin 2 JBrowse link 13 51,569,248 51,577,824 RGD:12802369
cerebral edema term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hvcn1 hydrogen voltage-gated channel 1 JBrowse link 12 39,822,814 39,851,093 RGD:14985213
decreased blood uric acid level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
decreased body temperature term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gimap5 GTPase, IMAP family member 5 JBrowse link 4 78,377,228 78,386,683 RGD:2303768
decreased cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1643359
G Srebf1_v2 sterol regulatory element binding factor 1, variant 2 RGD:1643359
decreased circulating alanine transaminase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased circulating alkaline phosphatase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:14696717
G Htr7em1Msu 5-hydroxytryptamine receptor 7; CRISPR/Cas9 induced mutant 1, Msu RGD:14696717
decreased circulating aspartate transaminase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
decreased circulating bicarbonate level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:13782272
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu RGD:13782272
decreased circulating bilirubin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased circulating chloride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased circulating cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:14696717
G Htr7em1Msu 5-hydroxytryptamine receptor 7; CRISPR/Cas9 induced mutant 1, Msu RGD:14696717
decreased circulating copper level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
decreased circulating creatinine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:14398462
G Cd40em1Uthal CD40 molecule; ZFN induced mutant 1, Uthal RGD:14398462
decreased circulating estradiol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:704424
decreased circulating glucose level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:2301945
G Glp1r glucagon-like peptide 1 receptor JBrowse link 20 9,586,075 9,626,228 RGD:625448
decreased circulating HDL cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
decreased circulating leptin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:11085488
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo RGD:11085488
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:12910109
decreased circulating luteinizing hormone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kiss1 KiSS-1 metastasis-suppressor JBrowse link 13 50,529,506 50,537,603 RGD:10059342
decreased circulating potassium level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased circulating progesterone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:704424
decreased circulating prolactin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased circulating serum albumin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:734959
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11566051
G F8em1Sage coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage RGD:11530071
decreased circulating total protein level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F8em1Sage coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage RGD:11530071
decreased circulating triglyceride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr7 5-hydroxytryptamine receptor 7 JBrowse link 1 254,547,964 254,671,811 RGD:14696717
G Htr7em1Msu 5-hydroxytryptamine receptor 7; CRISPR/Cas9 induced mutant 1, Msu RGD:14696717
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased collagen level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:14398462
G Cd40em1Uthal CD40 molecule; ZFN induced mutant 1, Uthal RGD:14398462
decreased dopamine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:13452381
decreased growth hormone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gh1sdr RGD:1578506
decreased prolactin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gh1sdr RGD:1578506
decreased serotonin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pax6 paired box 6 JBrowse link 3 95,700,241 95,728,682 RGD:8552339
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:4889487
decreased triglyceride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppp4r3b protein phosphatase 4, regulatory subunit 3B JBrowse link 14 113,570,150 113,618,138 RGD:2300117
decreased urine albumin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:11085830
G Nox4em2Mcwi NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:11085830
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7207429
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:7207429
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:13442483
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442483
G Shc1 SHC adaptor protein 1 JBrowse link 2 188,745,503 188,757,066 RGD:12792230
G Shc1em4Mcwi SHC adaptor protein 1; ZFN induced mutant 4, Medical College of Wisconsin RGD:12792230
decreased urine creatinine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcn6 chloride voltage-gated channel 6 JBrowse link 5 164,811,815 164,844,554 RGD:8662415
decreased urine protein level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:14398462
G Cd40em1Uthal CD40 molecule; ZFN induced mutant 1, Uthal RGD:14398462
G Clcn6 chloride voltage-gated channel 6 JBrowse link 5 164,811,815 164,844,554 RGD:8662415
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 JBrowse link 1 131,447,671 131,465,749 RGD:10401852
G Nr2f2em1Mcwi nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:10401852
G Plekha7 pleckstrin homology domain containing A7 JBrowse link 1 185,427,600 185,493,985 RGD:11079199
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin RGD:11079199
decreased urine sodium level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Clcn6 chloride voltage-gated channel 6 JBrowse link 5 164,811,815 164,844,554 RGD:8662415
hyperglycemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:9835029
impaired glucose tolerance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1600636
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage RGD:12910100
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12910507
G Leprem3 leptin receptor; TALEN induced mutant 3 RGD:12910507
increased bile salt level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:12910748
increased bleeding time term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lyst lysosomal trafficking regulator JBrowse link 17 90,323,055 90,522,091 RGD:1302441
G Rab38 RAB38, member RAS oncogene family JBrowse link 1 152,072,716 152,153,449 RGD:2324690
G Rab38ru Rab38, member of RAS oncogene family, ruby allele RGD:2324690
increased blood urea nitrogen level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11566051
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:13782272
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu RGD:13782272
increased body temperature term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:1581859
increased circulating alanine transaminase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12910507
RGD:13432147
G Leprem3 leptin receptor; TALEN induced mutant 3 RGD:12910507
G Leprfa leptin receptor; fa mutant RGD:13432147
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:2316657
increased circulating aldosterone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
increased circulating alkaline phosphatase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:13703118
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 RGD:13703118
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:2316657
increased circulating aspartate transaminase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:13703118
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 RGD:13703118
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12910507
G Leprem3 leptin receptor; TALEN induced mutant 3 RGD:12910507
increased circulating bilirubin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:14985241
G Abcc2TR- ATP binding cassette subfamily C member 2;transport deficient mutant , RGD:14985241
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:13432067
G Ugt1a1j UDP glucuronosyltransferase family 1 member A1, jaundice mutant RGD:13432067
increased circulating chloride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:13782272
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu RGD:13782272
increased circulating cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:11085488
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo RGD:11085488
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:13703118
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 RGD:13703118
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:8549777
G Lepm1Kyo leptin; ENU induced mutant1, Kyo RGD:8549777
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12910507
RGD:13432147
G Leprem3 leptin receptor; TALEN induced mutant 3 RGD:12910507
G Leprfa leptin receptor; fa mutant RGD:13432147
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:12880447
RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:12880447
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:13825242
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr RGD:13825242
increased circulating corticosterone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:10449008
increased circulating creatine kinase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:12880034
G Dmdem1Ang dystrophin; TALEN-induced mutant1, Ang RGD:12880034
increased circulating creatinine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:12880447
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:12880447
increased circulating follicle stimulating hormone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8552987
G Esr1em1Soar estrogen receptor 1; ZFN induced mutant 1, Soar RGD:8552987
increased circulating free fatty acid level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:2301945
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage RGD:12910100
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:13825242
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr RGD:13825242
increased circulating glucose level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:13703118
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 RGD:13703118
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
increased circulating HDL cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
increased circulating insulin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:11085488
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo RGD:11085488
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:13825242
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr RGD:13825242
increased circulating interleukin-6 level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:11533328
G Adora2bem2Mcwi adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:11533328
increased circulating LDL cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
increased circulating leptin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:737686
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage RGD:12910100
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:6478803
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr RGD:6478803
increased circulating luteinizing hormone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8552987
G Esr1em1Soar estrogen receptor 1; ZFN induced mutant 1, Soar RGD:8552987
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
increased circulating phosphate level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc6 ATP binding cassette subfamily C member 6 JBrowse link 1 101,954,786 102,013,252 RGD:13792593
G Abcc6em2Qlju ATP-binding cassette, subfamily C (CFTR/MRP), member 6; zinc finger nuclease induced mutant 2, Qiaoli Li RGD:13792593
increased circulating potassium level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:13782272
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu RGD:13782272
increased circulating serum albumin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
increased circulating sodium level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 JBrowse link 8 33,490,280 33,519,127 RGD:13782272
G Kcnj1em1Kasu potassium voltage-gated channel subfamily J member 1; ZFN induced mutant 1,Kasu RGD:13782272
increased circulating testosterone level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
increased circulating triglyceride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:11085488
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo RGD:11085488
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:2301945
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:8549777
G Lepm1Kyo leptin; ENU induced mutant1, Kyo RGD:8549777
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12910507
G Leprem3 leptin receptor; TALEN induced mutant 3 RGD:12910507
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:13825242
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr RGD:13825242
increased circulating tyrosine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fah fumarylacetoacetate hydrolase JBrowse link 1 146,713,663 146,736,339 RGD:14398823
G Fahem15Dlli-/- fumarylacetoacetate hydrolase; CRISPR/Cas9 induced mutant 15, Dlli RGD:14398823
increased creatine kinase level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dmd dystrophin JBrowse link X 51,149,358 53,519,271 RGD:11040981
G Dmdem1Kykn dystrophin; CRISPR/Cas9 system induced mutant 1, Keitaro Yamanouchi RGD:11040981
G Lamp2 lysosomal-associated membrane protein 2 JBrowse link X 124,722,628 124,766,079 RGD:13703117
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 RGD:13703117
increased dopamine level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:13210569
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:13210569
increased glycosylated hemoglobin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:13825242
G Mc4rm1Hubr melanocortin 4 receptor; ENU induced mutation 1, Hubr RGD:13825242
increased insulin secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Glp1r glucagon-like peptide 1 receptor JBrowse link 20 9,586,075 9,626,228 RGD:625448
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
increased liver cholesterol level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage RGD:12910100
increased liver copper level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
increased liver free fatty acids level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:12910104
G Ldlrem1 low density lipoprotein receptor; ZFN induced mutant 1 RGD:12910104
increased liver triglyceride level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp7bhts ATPase copper transporting beta; hepatitis RGD:2292672
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:11085488
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo RGD:11085488
G Ldlrem1Sage low density lipoprotein receptor; ZFN induced mutant 1, Sage RGD:12910100
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:8549777
G Lepm1Kyo leptin; ENU induced mutant1, Kyo RGD:8549777
increased oxygen consumption term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin JBrowse link 1 225,035,956 225,046,137 RGD:11085488
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo RGD:11085488
increased partial thromboplastin time term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F8em1Sage coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage RGD:11530071
increased response to stress-induced hyperthermia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc6a4 solute carrier family 6 member 4 JBrowse link 10 63,153,656 63,188,377 RGD:4889490
increased serotonin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:13210569
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:13210569
increased urine glucose level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:9835029
increased urine protein level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actr3 actin related protein 3 JBrowse link 13 41,695,520 41,738,622 RGD:2292230
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 JBrowse link 1 35,067,268 35,200,530 RGD:9685162
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj RGD:9685162
G Agtrap angiotensin II receptor-associated protein JBrowse link 5 164,888,069 164,898,387 RGD:8662415
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:8662415
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 1 162,369,801 162,376,024 RGD:11040458
G Ndufc2em2Mcwi NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:11040458
G Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 JBrowse link 5 164,720,629 164,747,071 RGD:8662415
G Resp18 regulated endocrine-specific protein 18 JBrowse link 9 82,470,794 82,477,136 RGD:14348960
G Resp18em2Mcwi regulated endocrine-specific protein 18; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:14348960
insulin resistance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:12911217

Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 4946
    homeostasis/metabolism phenotype 1069
      abnormal homeostasis 1009
        abnormal adaptive thermogenesis + 7
        abnormal amino acid level + 38
        abnormal ammonia homeostasis + 0
        abnormal blood homeostasis + 569
        abnormal body temperature + 4
        abnormal body temperature homeostasis + 2
        abnormal catecholamine level + 22
        abnormal circadian hormone homeostasis 0
        abnormal energy homeostasis + 2
        abnormal enzyme/coenzyme level + 31
        abnormal fluid regulation + 4
        abnormal galactose homeostasis 0
        abnormal gas homeostasis + 6
        abnormal glucose homeostasis + 310
        abnormal glycosaminoglycan level + 0
        abnormal histamine physiology 0
        abnormal hormone level + 225
        abnormal ion homeostasis + 36
        abnormal lipid homeostasis + 289
        abnormal lipoprotein level + 35
        abnormal mineral homeostasis + 22
        abnormal pH regulation + 0
        abnormal porphyrin level + 0
        abnormal protein level + 59
        abnormal susceptibility to non-insulin-dependent diabetes + 0
        abnormal urine homeostasis + 352
        abnormal vitamin homeostasis + 1
        ketosis + 2
        photosensitivity + 0
        phototoxicity 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.