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ONTOLOGY REPORT - ANNOTATIONS


Term:abnormal immune system physiology
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Accession:MP:0001790 term browser browse the term
Definition:deviation from the normal function of the immune system
Synonyms:exact_synonym: immune system/response abnormalities;   immune system: response/ function abnormalities
 alt_id: MP:0001789
 xref: GO:0006955


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abnormal interferon level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
abnormal microglial cell activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:12879399
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo RGD:12879399
abnormal response to transplant term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:1580413
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1580395
brain inflammation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rnaset2 ribonuclease T2 JBrowse link 1 53,174,879 53,192,048 RGD:13781889
G Rnaset2em1Sage ribonuclease T2; CRISPR/Cas9 induced mutant 1, Sage RGD:13781889
decreased immunoglobulin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:8696027
decreased inflammatory response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:11533328
G Adora2bem2Mcwi adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:11533328
decreased splenocyte proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
decreased susceptibility to autoimmune diabetes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:12910492
G Ifnar1em1 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1 RGD:12910492
G Ifnar1em2 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2 RGD:12910492
decreased susceptibility to experimental autoimmune myasthenia gravis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1600670
decreased susceptibility to virus induced diabetes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:12910492
decreased tumor necrosis factor secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:12910488
G Tlr4em1Geh toll-like receptor 4; mutation 1, Gregg E. Homanics RGD:12910488
increased circulating interleukin-6 level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2b adenosine A2B receptor JBrowse link 10 48,569,563 48,586,366 RGD:11533328
G Adora2bem2Mcwi adenosine A2B receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:11533328
increased susceptibility to induced arthritis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:628543
increased susceptibility to type III hypersensitivity reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:13792592
G Cd59em1Ask CD59 molecule; CRISPR/Cas9 induced mutant1, Ask RGD:13792592
increased susceptibility to viral infection induced morbidity/mortality term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:12910492
G Ifnar1em1 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1 RGD:12910492
G Ifnar1em2 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2 RGD:12910492
insulitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:12910492
G Ifnar1em1 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1 RGD:12910492
G Ifnar1em2 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2 RGD:12910492

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  mammalian phenotype 4934
    immune system phenotype 413
      abnormal immune system physiology 338
        abnormal adaptive immunity + 36
        abnormal antigen presentation + 13
        abnormal cell-mediated immunity + 33
        abnormal humoral immune response + 23
        abnormal hypersensitivity reaction + 4
        abnormal immune cell physiology + 33
        abnormal immune organ physiology + 3
        abnormal immune serum protein physiology + 49
        abnormal immune tolerance + 109
        abnormal immunoglobulin transcytosis 0
        abnormal inflammatory response + 230
        abnormal innate immunity + 16
        abnormal lymphatic system physiology + 0
        abnormal response to antigen + 0
        abnormal response to infection + 25
        abnormal response to transplant + 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.