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Term:abnormal humoral immune response
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Accession:MP:0001800 term browser browse the term
Definition:any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination
Synonyms:exact_synonym: abnormal humoural immune response;   antibody-mediated immune response abnormalities;   humoral immune response dysfunction;   humoural immune response dysfunction

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decreased immunoglobulin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:8696027

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  mammalian phenotype 4930
    immune system phenotype 414
      abnormal immune system physiology 339
        abnormal humoral immune response 23
          abnormal complement pathway + 0
          abnormal immunoglobulin level + 23
          enhanced humoral immune response 0
          impaired humoral immune response 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.