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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:altered tumor susceptibility
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Accession:MP:0002166 term browser browse the term
Definition:greater than or less than the average number of tumors, usually a specific type, arising in a given organism when compared to controls
Synonyms:exact_synonym: altered tumor resistance;   altered tumour resistance;   altered tumour susceptibility;   tumorigenesis: altered tumor susceptibility/resistance;   tumourigenesis: altered tumour susceptibility/resistance
 broad_synonym: altered neoplastic susceptibility
 xref: MGI:2173626


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increased incidence of induced tumors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rag2 recombination activating 2 induced IMP XCO:0000709 RGD PMID:30206106 RGD:38508903 NCBI chr 3:91,191,837...91,200,134
Ensembl chr 3:91,191,837...91,200,134
JBrowse link
increased mesothelioma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A IAGP DNA:deletion RGD PMID:20065947 RGD:7248760 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IAGP DNA:deletion RGD PMID:20065947 RGD:7248760 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104
JBrowse link
increased osteosarcoma incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 IAGP DNA:deletion RGD PMID:19825367 RGD:5147850 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
increased tumor incidence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 IMP RGD PMID:22917926 RGD:11075077 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53em1Sage tumor protein p53; ZFN induced mutant 1, Sage IMP RGD PMID:22917926 RGD:11075077

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 4973
    neoplasm 213
      altered tumor susceptibility 205
        abnormal tumor incidence + 194
        abnormal tumor latency + 17
        preneoplasia 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.