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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal professional antigen presenting cell physiology
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Accession:MP:0002452 term browser browse the term
Definition:any functional anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response
Synonyms:exact_synonym: antigen presenting cell dysfunction
 related_synonym: abnormal antigen presenting cell physiology

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abnormal microglial cell activation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP DNA:deletion:exon: RGD PMID:28007901 RGD:12879399 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
decreased immunoglobulin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
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Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 4967
    immune system phenotype 427
      abnormal immune system physiology 346
        abnormal immune cell physiology 36
          abnormal professional antigen presenting cell physiology 27
            abnormal B cell physiology + 24
            abnormal dendritic cell physiology + 0
            abnormal macrophage physiology + 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.