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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal B cell physiology
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Accession:MP:0002459 term browser browse the term
Definition:any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
Synonyms:exact_synonym: B cell dysfunction;   B lymphocyte dysfunction;   B lymphocyte functional anomalies


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decreased immunoglobulin level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkdc protein kinase, DNA-activated, catalytic subunit IMP RGD PMID:22981234 RGD:8696027 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
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Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 4973
    immune system phenotype 429
      abnormal immune system physiology 348
        abnormal cell-mediated immunity 38
          abnormal professional antigen presenting cell physiology 27
            abnormal B cell physiology 24
              abnormal B cell activation + 0
              abnormal B cell apoptosis + 0
              abnormal B lymphocyte antigen presentation 0
              abnormal class switch recombination 0
              abnormal follicular B cell physiology 0
              abnormal germinal center B cell physiology 0
              abnormal immunoglobulin level + 24
              abnormal marginal zone B cell physiology 0
              abnormal memory B cell physiology 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 4973
    immune system phenotype 429
      abnormal immune system physiology 348
        abnormal immune cell physiology 38
          abnormal leukocyte physiology 38
            abnormal lymphocyte physiology 35
              abnormal B cell physiology 24
                abnormal B cell activation + 0
                abnormal B cell apoptosis + 0
                abnormal B lymphocyte antigen presentation 0
                abnormal class switch recombination 0
                abnormal follicular B cell physiology 0
                abnormal germinal center B cell physiology 0
                abnormal immunoglobulin level + 24
                abnormal marginal zone B cell physiology 0
                abnormal memory B cell physiology 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.