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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased IgE level
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Accession:MP:0002497 term browser browse the term
Definition:greater than normal immunoglobulin class E level


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increased IgE level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A IAGP MGI PMID:9820555 NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 IAGP MGI PMID:25902485 NCBI chr12:21,323,509...21,373,632
Ensembl chr12:21,323,509...21,373,632
JBrowse link
G Asf1b anti-silencing function 1B histone chaperone IEA MGI NCBI chr 8:83,955,694...83,970,195
Ensembl chr 8:83,955,507...83,970,197
JBrowse link
G Bcl10 B cell leukemia/lymphoma 10 IEA MGI NCBI chr 3:145,924,262...145,934,366
Ensembl chr 3:145,922,804...145,934,356
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 IAGP MGI PMID:11668339 NCBI chr 6:108,660,629...108,666,925
Ensembl chr 6:108,660,629...108,666,925
JBrowse link
G Blk B lymphoid kinase IEA MGI NCBI chr14:63,372,837...63,417,187
Ensembl chr14:63,372,836...63,417,037
JBrowse link
G Btk Bruton agammaglobulinemia tyrosine kinase IEA MGI NCBI chr  X:134,542,334...134,583,628
Ensembl chr  X:134,542,336...134,583,570
JBrowse link
G Cabin1 calcineurin binding protein 1 IAGP MGI PMID:11714752 NCBI chr10:75,646,110...75,764,357
Ensembl chr10:75,646,112...75,764,341
JBrowse link
G Card11 caspase recruitment domain family, member 11 IAGP MGI PMID:12818157 NCBI chr 5:140,872,999...141,000,596
Ensembl chr 5:140,872,990...141,000,582
JBrowse link
G Casp8 caspase 8 IAGP MGI PMID:21135236 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Cbfb core binding factor beta IAGP MGI PMID:17646405 NCBI chr 8:105,170,674...105,217,989
Ensembl chr 8:105,170,674...105,217,989
JBrowse link
G Ccr4 chemokine (C-C motif) receptor 4 IAGP MGI PMID:12154006 NCBI chr 9:114,490,316...114,505,476
Ensembl chr 9:114,490,316...114,504,916
JBrowse link
G Ccr7 chemokine (C-C motif) receptor 7 IAGP MGI PMID:10520991 NCBI chr11:99,144,199...99,155,077
Ensembl chr11:99,144,196...99,155,077
JBrowse link
G Cd19 CD19 antigen IAGP MGI PMID:20826752, PMID:21339646 NCBI chr 7:126,408,448...126,415,148
Ensembl chr 7:126,408,450...126,414,889
JBrowse link
G Col17a1 collagen, type XVII, alpha 1 IAGP MGI PMID:25310407 NCBI chr19:47,646,341...47,692,042
Ensembl chr19:47,646,344...47,692,094
JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) IAGP MGI PMID:12732663 NCBI chr11:54,247,270...54,249,899
Ensembl chr11:54,247,271...54,249,667
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 IAGP MGI PMID:18845758 NCBI chr 1:60,909,025...60,915,832
Ensembl chr 1:60,887,000...60,915,832
JBrowse link
G Ctse cathepsin E IAGP MGI PMID:14769879 NCBI chr 1:131,638,314...131,675,507
Ensembl chr 1:131,638,306...131,675,505
JBrowse link
G Cxcr2 chemokine (C-X-C motif) receptor 2 IAGP MGI PMID:11801688 NCBI chr 1:74,153,994...74,161,246
Ensembl chr 1:74,153,989...74,161,246
JBrowse link
G Dck deoxycytidine kinase IEA MGI NCBI chr 5:88,765,013...88,783,277
Ensembl chr 5:88,764,996...88,783,281
JBrowse link
G Dock2 dedicator of cyto-kinesis 2 IAGP MGI PMID:19103880 NCBI chr11:34,226,815...34,783,905
Ensembl chr11:34,226,815...34,783,892
JBrowse link
G Dsg3 desmoglein 3 IAGP MGI PMID:8182278 NCBI chr18:20,510,274...20,541,310
Ensembl chr18:20,510,274...20,547,459
JBrowse link
G Dsg4 desmoglein 4 IAGP MGI PMID:10839719 NCBI chr18:20,436,175...20,471,821
Ensembl chr18:20,436,175...20,471,821
JBrowse link
G Ebi3 Epstein-Barr virus induced gene 3 IAGP MGI PMID:18779924 NCBI chr17:55,952,623...55,957,022
Ensembl chr17:55,952,640...55,957,022
JBrowse link
G Efhd2 EF hand domain containing 2 IAGP MGI PMID:25092375 NCBI chr 4:141,858,142...141,874,920
Ensembl chr 4:141,858,142...141,874,920
JBrowse link
G Egfr epidermal growth factor receptor IAGP MGI PMID:25902485 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 IAGP MGI PMID:25692702 NCBI chr10:24,773,814...24,836,195
Ensembl chr10:24,772,406...24,842,823
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) IAGP MGI PMID:16301622, PMID:18779924 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) IAGP MGI PMID:19794494 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide IAGP MGI PMID:9062348 NCBI chr 1:171,229,572...171,234,349
Ensembl chr 1:171,229,572...171,234,365
JBrowse link
G Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide IAGP MGI PMID:8008068, PMID:8144922, PMID:10508270, PMID:12637252, PMID:15503007, PMID:23423996 NCBI chr 8:3,680,280...3,694,174
Ensembl chr 8:3,681,737...3,694,175
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 IAGP MGI PMID:20308431 NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IAGP MGI PMID:20308431 NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Flg filaggrin IAGP MGI PMID:19349982, PMID:22409988, PMID:24084074 NCBI chr 3:93,273,546...93,293,689
Ensembl chr 3:93,273,523...93,293,686
JBrowse link
G Foxp3 forkhead box P3 IAGP MGI PMID:16275384, PMID:18845758, PMID:24135136 NCBI chr  X:7,579,676...7,595,243
Ensembl chr  X:7,573,644...7,595,245
JBrowse link
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano IAGP MGI PMID:21339646 NCBI chr 6:113,067,428...113,077,244
Ensembl chr 6:113,067,428...113,077,333
JBrowse link
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 IAGP MGI PMID:26263558 NCBI chr19:34,550,550...34,576,534
Ensembl chr19:34,550,694...34,576,419
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 IAGP MGI PMID:23115618 NCBI chr 7:140,967,429...140,969,827
Ensembl chr 7:140,967,221...140,969,825
JBrowse link
G Ifng interferon gamma IAGP MGI PMID:7908325, PMID:12732663 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igh immunoglobulin heavy chain complex IAGP MGI PMID:20511552, PMID:24019479 NCBI chr12:113,258,768...116,009,954 JBrowse link
G Igh-7 immunoglobulin heavy chain 7 (heavy chain of IgE) IAGP MGI PMID:18925577
G Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) IAGP MGI PMID:21339646, PMID:23423996 NCBI chr12:113,326,541...113,330,523
Ensembl chr12:113,325,240...113,330,523
JBrowse link
G Ikzf3 IKAROS family zinc finger 3 IAGP MGI PMID:9806640 NCBI chr11:98,464,610...98,546,031
Ensembl chr11:98,464,902...98,546,031
JBrowse link
G Il10 interleukin 10 IAGP MGI PMID:10811896 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il13ra2 interleukin 13 receptor, alpha 2 IAGP MGI PMID:12642602 NCBI chr  X:147,383,478...147,429,192
Ensembl chr  X:147,383,476...147,429,192
JBrowse link
G Il21 interleukin 21 IAGP MGI PMID:16979605 NCBI chr 3:37,222,759...37,232,636
Ensembl chr 3:37,222,759...37,232,636
JBrowse link
G Il21r interleukin 21 receptor IAGP MGI PMID:11970879, PMID:12446913, PMID:17077330 NCBI chr 7:125,603,252...125,634,397
Ensembl chr 7:125,603,429...125,633,570
JBrowse link
G Il25 interleukin 25 IAGP MGI PMID:16606668 NCBI chr14:54,932,695...54,935,837
Ensembl chr14:54,932,695...54,935,837
JBrowse link
G Il27ra interleukin 27 receptor, alpha IAGP MGI PMID:16301622 NCBI chr 8:84,030,286...84,042,600
Ensembl chr 8:84,030,294...84,042,589
JBrowse link
G Il2rb interleukin 2 receptor, beta chain IAGP MGI PMID:7770771 NCBI chr15:78,479,256...78,511,621
Ensembl chr15:78,479,256...78,495,271
JBrowse link
G Il31ra interleukin 31 receptor A IAGP MGI PMID:17353366 NCBI chr13:112,521,931...112,580,732
Ensembl chr13:112,519,898...112,594,360
JBrowse link
G Il4ra interleukin 4 receptor, alpha IAGP MGI PMID:14557412, PMID:19770271, PMID:20392476 NCBI chr 7:125,552,271...125,579,474
Ensembl chr 7:125,552,120...125,579,474
JBrowse link
G Il6st interleukin 6 signal transducer IAGP MGI PMID:9815272 NCBI chr13:112,464,070...112,506,860
Ensembl chr13:112,464,070...112,510,086
JBrowse link
G Itch itchy, E3 ubiquitin protein ligase IAGP MGI PMID:24135136 NCBI chr 2:155,133,481...155,226,855
Ensembl chr 2:155,133,509...155,226,855
JBrowse link
G Itgb2 integrin beta 2 IEA MGI NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Itk IL2 inducible T cell kinase IAGP MGI PMID:19416854 NCBI chr11:46,325,148...46,389,515
Ensembl chr11:46,325,150...46,389,515
JBrowse link
G Jak3 Janus kinase 3 IEA MGI NCBI chr 8:71,676,383...71,690,577
Ensembl chr 8:71,676,296...71,690,575
JBrowse link
G Junb jun B proto-oncogene IAGP MGI PMID:19918056 NCBI chr 8:84,976,909...84,978,748
Ensembl chr 8:84,974,484...84,978,718
Ensembl chr 8:84,974,484...84,978,718
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IAGP MGI PMID:20512127 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Klf2 Kruppel-like factor 2 (lung) IAGP MGI PMID:19592277 NCBI chr 8:72,319,062...72,321,654
Ensembl chr 8:72,319,033...72,321,656
JBrowse link
G Kprp keratinocyte expressed, proline-rich IAGP MGI PMID:30905808 NCBI chr 3:92,823,074...92,827,247
Ensembl chr 3:92,823,074...92,827,247
JBrowse link
G Lat linker for activation of T cells IAGP MGI PMID:12065839, PMID:12065840, PMID:12970761, PMID:16887989, PMID:19682930 NCBI chr 7:126,363,827...126,369,705
Ensembl chr 7:126,363,824...126,369,570
JBrowse link
G Lax1 lymphocyte transmembrane adaptor 1 IAGP MGI PMID:15843560 NCBI chr 1:133,679,017...133,693,022
Ensembl chr 1:133,679,091...133,690,108
JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 IEA MGI NCBI chr11:34,046,928...34,092,281
Ensembl chr11:34,046,920...34,092,295
JBrowse link
G Lepr leptin receptor IEA MGI NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lpar2 lysophosphatidic acid receptor 2 IAGP MGI PMID:22427635 NCBI chr 8:69,822,565...69,831,102
Ensembl chr 8:69,822,429...69,831,102
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase IAGP MGI PMID:19201855, PMID:20512127 NCBI chr 4:3,678,068...3,791,612
Ensembl chr 4:3,678,115...3,813,122
JBrowse link
G Mmp9 matrix metallopeptidase 9 IAGP MGI PMID:14764732 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Myd88 myeloid differentiation primary response gene 88 IAGP MGI PMID:16703567 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411
JBrowse link
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 IAGP MGI PMID:14573689 NCBI chr 2:168,476,410...168,601,657
Ensembl chr 2:168,476,410...168,601,657
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 IAGP MGI PMID:9529315 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha IAGP MGI PMID:11067893 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta IAGP MGI PMID:15491998, PMID:18441309 NCBI chr16:55,811,375...55,838,954
Ensembl chr16:55,811,375...55,838,899
JBrowse link
G Nipal3 NIPA-like domain containing 3 IAGP MGI PMID:19738379 NCBI chr 4:135,442,805...135,494,972
Ensembl chr 4:135,445,420...135,495,038
JBrowse link
G Nlrp1a NLR family, pyrin domain containing 1A IEA MGI NCBI chr11:71,091,197...71,144,969
Ensembl chr11:71,092,236...71,144,704
JBrowse link
G Pigr polymeric immunoglobulin receptor IAGP MGI PMID:10553061 NCBI chr 1:130,826,684...130,852,249
Ensembl chr 1:130,826,684...130,852,249
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta IAGP MGI PMID:20826752 NCBI chr 4:149,649,168...149,702,566
Ensembl chr 4:149,649,168...149,702,571
JBrowse link
G Pld4 phospholipase D family, member 4 IAGP MGI PMID:30679154 NCBI chr12:112,760,446...112,768,986
Ensembl chr12:112,760,655...112,768,990
JBrowse link
G Ppia peptidylprolyl isomerase A IAGP MGI PMID:15308100 NCBI chr11:6,415,867...6,419,817
Ensembl chr11:6,415,443...6,419,817
JBrowse link
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 IAGP MGI PMID:16397132 NCBI chr18:77,794,550...77,882,879
Ensembl chr18:77,789,914...77,882,879
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) IAGP MGI PMID:14752163, PMID:23619366 NCBI chr 3:103,856,575...103,912,252
Ensembl chr 3:103,859,795...103,912,247
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 IAGP MGI PMID:15235600 NCBI chr 5:130,171,819...130,214,342
Ensembl chr 5:130,171,798...130,214,342
JBrowse link
G Rag1 recombination activating 1 IAGP MGI PMID:11696599 NCBI chr 2:101,638,252...101,649,532
Ensembl chr 2:101,638,282...101,649,501
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 IAGP MGI PMID:22719950 NCBI chr 2:117,279,983...117,342,877
Ensembl chr 2:117,279,993...117,343,001
JBrowse link
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B IAGP MGI PMID:9164938 NCBI chr 7:19,606,217...19,629,438
Ensembl chr 7:19,606,217...19,629,438
JBrowse link
G Retnla resistin like alpha IAGP MGI PMID:19349464 NCBI chr16:48,842,609...48,844,461
Ensembl chr16:48,842,551...48,844,461
JBrowse link
G Rora RAR-related orphan receptor alpha IAGP MGI PMID:16973978 NCBI chr 9:68,653,404...69,388,246
Ensembl chr 9:68,653,786...69,388,246
JBrowse link
G Runx3 runt related transcription factor 3 IAGP MGI PMID:16027362 NCBI chr 4:135,120,645...135,177,990
Ensembl chr 4:135,120,652...135,177,990
JBrowse link
G Sema4b sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B IAGP MGI PMID:21270411 NCBI chr 7:80,186,870...80,226,646
Ensembl chr 7:80,186,841...80,226,527
JBrowse link
G Siae sialic acid acetylesterase IAGP MGI PMID:19103880 NCBI chr 9:37,613,821...37,648,258
Ensembl chr 9:37,555,698...37,649,655
JBrowse link
G Sox9 SRY (sex determining region Y)-box 9 IAGP MGI PMID:25902485 NCBI chr11:112,782,210...112,787,757
Ensembl chr11:112,782,224...112,787,760
JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:9492006 NCBI chr10:127,642,955...127,660,987
Ensembl chr10:127,642,986...127,660,957
JBrowse link
G Stk4 serine/threonine kinase 4 IEA MGI NCBI chr 2:164,074,113...164,155,524
Ensembl chr 2:164,070,322...164,155,524
JBrowse link
G Tcra T cell receptor alpha chain IAGP MGI PMID:8208291 NCBI chr14:52,427,967...54,224,198 JBrowse link
G Tg thyroglobulin IEA MGI NCBI chr15:66,670,754...66,850,721
Ensembl chr15:66,670,753...66,850,721
JBrowse link
G Tmem219 transmembrane protein 219 IAGP MGI PMID:27629921 NCBI chr 7:126,886,219...126,928,821
Ensembl chr 7:126,886,171...126,922,917
JBrowse link
G Tmem79 transmembrane protein 79 IAGP MGI PMID:24084074 NCBI chr 3:88,328,653...88,334,433
Ensembl chr 3:88,328,655...88,336,148
JBrowse link
G Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 IAGP MGI PMID:11714751 NCBI chr17:43,016,555...43,089,188
Ensembl chr17:43,016,555...43,089,189
JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 IAGP MGI PMID:21606507 NCBI chr11:54,910,787...54,962,956
Ensembl chr11:54,910,785...54,962,917
JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 IAGP MGI PMID:15485634, PMID:20660351 NCBI chr10:39,612,934...39,655,307
Ensembl chr10:39,612,934...39,655,307
JBrowse link
G Was Wiskott-Aldrich syndrome IAGP MGI PMID:22302739 NCBI chr  X:8,081,466...8,090,491
Ensembl chr  X:8,081,453...8,090,498
JBrowse link
G Wipf1 WAS/WASL interacting protein family, member 1 IAGP MGI PMID:11869681 NCBI chr 2:73,429,610...73,529,487
Ensembl chr 2:73,429,610...73,529,734
JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase IAGP MGI PMID:17767948 NCBI chr 1:36,761,798...36,782,821
Ensembl chr 1:36,761,798...36,782,818
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 14717
    immune system phenotype 4509
      abnormal immune system physiology 3135
        abnormal immune serum protein physiology 1330
          abnormal immunoglobulin level 657
            increased immunoglobulin level 421
              increased IgE level 111
Path 2
Term Annotations click to browse term
  mammalian phenotype 14717
    immune system phenotype 4509
      abnormal immune system physiology 3135
        abnormal immune cell physiology 1685
          abnormal leukocyte physiology 1649
            abnormal lymphocyte physiology 1234
              abnormal B cell physiology 785
                abnormal immunoglobulin level 657
                  increased immunoglobulin level 421
                    increased IgE level 111
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.