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ONTOLOGY REPORT - ANNOTATIONS


Term:abnormal type IV hypersensitivity reaction
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Accession:MP:0002534 term browser browse the term
Definition:anomaly in an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact
Comment:Examples: granulomatous diseases: tuberculosis, sarcoidosis. contact dermatitis: elicited by poison ivy, detergents, clothing, etc.
Synonyms:exact_synonym: cell-mediated hypersensitivity;   contact hypersensitivity;   delayed type hypersensitivity


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abnormal type IV hypersensitivity reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actb actin, beta JBrowse link 5 142,903,115 142,907,976 RGD:5509061
G Cd207 CD207 antigen JBrowse link 6 83,671,207 83,677,857 RGD:5509061
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:5509061
G Gadd45g growth arrest and DNA-damage-inducible 45 gamma JBrowse link 13 51,846,675 51,848,475 RGD:5509061
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:5509061
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:5509061
G Il20 interleukin 20 JBrowse link 1 130,906,985 130,911,296 RGD:5509061
G Laptm5 lysosomal-associated protein transmembrane 5 JBrowse link 4 130,912,890 130,936,148 RGD:5509061
G Mst1r macrophage stimulating 1 receptor (c-met-related tyrosine kinase) JBrowse link 9 107,906,858 107,920,383 RGD:5509061
G Sele selectin, endothelial cell JBrowse link 1 164,039,614 164,058,487 RGD:5509061
G Sell selectin, lymphocyte JBrowse link 1 164,061,987 164,082,930 RGD:5509061
G Sgpl1 sphingosine phosphate lyase 1 JBrowse link 10 61,098,642 61,147,684 RGD:5509061
G Tgfbr1 transforming growth factor, beta receptor I JBrowse link 4 47,353,222 47,414,926 RGD:5509061
decreased susceptibility to type IV hypersensitivity reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl-hydrocarbon receptor JBrowse link 12 35,497,979 35,534,989 RGD:5509061
G Anxa5 annexin A5 JBrowse link 3 36,448,923 36,475,887 RGD:5509061
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:5509061
G B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 JBrowse link 4 40,804,602 40,853,984 RGD:5509061
G B4gat1 beta-1,4-glucuronyltransferase 1 JBrowse link 19 5,038,826 5,041,134 RGD:5509061
G Ccl17 chemokine (C-C motif) ligand 17 JBrowse link 8 94,809,380 94,812,038 RGD:5509061
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:5509061
G Ccl5 chemokine (C-C motif) ligand 5 JBrowse link 11 83,525,778 83,530,518 RGD:5509061
G Ccr7 chemokine (C-C motif) receptor 7 JBrowse link 11 99,144,199 99,155,077 RGD:5509061
G Cd207 CD207 antigen JBrowse link 6 83,671,207 83,677,857 RGD:5509061
G Cd28 CD28 antigen JBrowse link 1 60,746,388 60,773,359 RGD:5509061
G Cd44 CD44 antigen JBrowse link 2 102,811,141 102,901,669 RGD:5509061
G Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) JBrowse link 18 60,803,849 60,812,652 RGD:5509061
G Cd83 CD83 antigen JBrowse link 13 43,785,112 43,803,133 RGD:5509061
G Cd99l2 CD99 antigen-like 2 JBrowse link X 71,420,060 71,492,866 RGD:5509061
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta JBrowse link 2 167,688,915 167,690,432 RGD:5509061
G Clec4d C-type lectin domain family 4, member d JBrowse link 6 123,262,107 123,275,268 RGD:5509061
G Clec4e C-type lectin domain family 4, member e JBrowse link 6 123,281,789 123,289,871 RGD:5509061
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:5509061
G Cxcl10 chemokine (C-X-C motif) ligand 10 JBrowse link 5 92,346,638 92,348,889 RGD:5509061
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 JBrowse link 2 181,141,758 181,157,015 RGD:5509061
G Ephb6 Eph receptor B6 JBrowse link 6 41,603,834 41,620,509 RGD:5509061
G F2rl1 coagulation factor II (thrombin) receptor-like 1 JBrowse link 13 95,511,718 95,525,240 RGD:5509061
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide JBrowse link 1 171,229,572 171,234,349 RGD:5509061
G Fut4 fucosyltransferase 4 JBrowse link 9 14,748,459 14,752,122 RGD:5509061
G Fut7 fucosyltransferase 7 JBrowse link 2 25,422,351 25,426,374 RGD:5509061
G Gcnt1 glucosaminyl (N-acetyl) transferase 1, core 2 JBrowse link 19 17,326,141 17,372,844 RGD:5509061
G H2-DMa histocompatibility 2, class II, locus DMa JBrowse link 17 34,119,693 34,139,101 RGD:5509061
G Icam1 intercellular adhesion molecule 1 JBrowse link 9 21,015,940 21,028,814 RGD:5509061
G Ido1 indoleamine 2,3-dioxygenase 1 JBrowse link 8 24,584,133 24,596,952 RGD:5509061
G Ido2 indoleamine 2,3-dioxygenase 2 JBrowse link 8 24,531,892 24,576,414 RGD:5509061
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:5509061
G Ifngr2 interferon gamma receptor 2 JBrowse link 16 91,547,059 91,564,007 RGD:5509061
G Ighm immunoglobulin heavy constant mu JBrowse link 12 113,418,826 113,422,730 RGD:5509061
G Il12a interleukin 12a JBrowse link 3 68,690,644 68,698,550 RGD:5509061
G Il12b interleukin 12b JBrowse link 11 44,400,063 44,414,677 RGD:5509061
G Il15 interleukin 15 JBrowse link 8 82,331,624 82,403,252 RGD:5509061
G Il17a interleukin 17A JBrowse link 1 20,730,905 20,734,496 RGD:5509061
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:5509061
G Il1b interleukin 1 beta JBrowse link 2 129,364,569 129,371,164 RGD:5509061
G Il1r1 interleukin 1 receptor, type I JBrowse link 1 40,222,480 40,316,201 RGD:5509061
G Il21r interleukin 21 receptor JBrowse link 7 125,603,252 125,634,397 RGD:5509061
G Il34 interleukin 34 JBrowse link 8 110,741,829 110,805,949 RGD:5509061
G Itgb2 integrin beta 2 JBrowse link 10 77,530,329 77,565,708 RGD:5509061
G Mmp19 matrix metallopeptidase 19 JBrowse link 10 128,790,910 128,800,827 RGD:5509061
G Mmp3 matrix metallopeptidase 3 JBrowse link 9 7,445,822 7,455,975 RGD:5509061
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 7 3,218,643 3,249,771 RGD:5509061
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:5509061
G Npy1r neuropeptide Y receptor Y1 JBrowse link 8 66,697,149 66,706,800 RGD:5509061
G Pgf placental growth factor JBrowse link 12 85,166,637 85,177,785 RGD:5509061
G Ptgdr2 prostaglandin D2 receptor 2 JBrowse link 19 10,924,519 10,942,511 RGD:5509061
G Ptger1 prostaglandin E receptor 1 (subtype EP1) JBrowse link 8 83,666,644 83,672,756 RGD:5509061
G Ptger4 prostaglandin E receptor 4 (subtype EP4) JBrowse link 15 5,233,399 5,244,187 RGD:5509061
G Pycard PYD and CARD domain containing JBrowse link 7 127,991,373 127,993,867 RGD:5509061
G Rag2 recombination activating gene 2 JBrowse link 2 101,624,712 101,632,528 RGD:5509061
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B JBrowse link 7 19,606,217 19,629,438 RGD:5509061
G Sell selectin, lymphocyte JBrowse link 1 164,061,987 164,082,930 RGD:5509061
G Selp selectin, platelet JBrowse link 1 164,115,264 164,150,026 RGD:5509061
G Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A JBrowse link 3 88,435,959 88,461,182 RGD:5509061
G Spp1 secreted phosphoprotein 1 JBrowse link 5 104,435,111 104,441,053 RGD:5509061
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:5509061
G Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 JBrowse link 4 150,920,155 150,946,104 RGD:5509061
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:5509061
G Trip10 thyroid hormone receptor interactor 10 JBrowse link 17 57,233,220 57,263,697 RGD:5509061
G Tyrobp TYRO protein tyrosine kinase binding protein JBrowse link 7 30,413,782 30,417,582 RGD:5509061
increased susceptibility to type IV hypersensitivity reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccr1 chemokine (C-C motif) receptor 1 JBrowse link 9 123,962,126 123,968,692 RGD:5509061
G Ccr5 chemokine (C-C motif) receptor 5 JBrowse link 9 124,121,543 124,127,183 RGD:5509061
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 17 78,850,504 78,882,572 RGD:5509061
G Epcam epithelial cell adhesion molecule JBrowse link 17 87,635,979 87,651,127 RGD:5509061
G F11r F11 receptor JBrowse link 1 171,437,561 171,464,593 RGD:5509061
G Fbn1 fibrillin 1 JBrowse link 2 125,300,594 125,506,485 RGD:5509061
G Flg filaggrin JBrowse link 3 93,273,546 93,293,689 RGD:5509061
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:5509061
G Gna12 guanine nucleotide binding protein, alpha 12 JBrowse link 5 140,759,944 140,830,431 RGD:5509061
G Gna13 guanine nucleotide binding protein, alpha 13 JBrowse link 11 109,362,794 109,401,369 RGD:5509061
G Gpa33 glycoprotein A33 (transmembrane) JBrowse link 1 166,130,221 166,166,510 RGD:5509061
G Gpr34 G protein-coupled receptor 34 JBrowse link X 13,622,650 13,640,859 RGD:5509061
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:5509061
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:5509061
G Il20rb interleukin 20 receptor beta JBrowse link 9 100,457,719 100,486,473 RGD:5509061
G Il27 interleukin 27 JBrowse link 7 126,589,009 126,595,035 RGD:5509061
G Lgals2 lectin, galactose-binding, soluble 2 JBrowse link 15 78,850,860 78,855,529 RGD:5509061
G Mir21a microRNA 21a JBrowse link 11 86,584,067 86,584,158 RGD:5509061
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:5509061
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 5 134,220,053 134,229,628 RGD:5509061
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 11 59,541,569 59,566,955 RGD:5509061
G Pla2g2d phospholipase A2, group IID JBrowse link 4 138,775,735 138,782,052 RGD:5509061
G Plcd1 phospholipase C, delta 1 JBrowse link 9 119,071,527 119,093,502 RGD:5509061
G Sstr4 somatostatin receptor 4 JBrowse link 2 148,395,377 148,396,764 RGD:5509061
G Tcrd T cell receptor delta chain JBrowse link 14 53,946,073 54,159,198 RGD:5509061
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 JBrowse link 2 126,791,558 126,876,261 RGD:5509061
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 140,539,528 140,600,522 RGD:5509061
G Vipr2 vasoactive intestinal peptide receptor 2 JBrowse link 12 116,077,420 116,148,637 RGD:5509061

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 14671
    immune system phenotype 4495
      abnormal immune system physiology 3123
        abnormal hypersensitivity reaction 193
          abnormal type IV hypersensitivity reaction 99
            decreased susceptibility to type IV hypersensitivity reaction 65
            increased susceptibility to type IV hypersensitivity reaction 28
Path 2
Term Annotations click to browse term
  mammalian phenotype 14671
    immune system phenotype 4495
      abnormal immune system physiology 3123
        abnormal inflammatory response 1619
          abnormal acute inflammation 377
            abnormal type IV hypersensitivity reaction 99
              decreased susceptibility to type IV hypersensitivity reaction 65
              increased susceptibility to type IV hypersensitivity reaction 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.