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ONTOLOGY REPORT - ANNOTATIONS


Term:abnormal basement membrane morphology
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Accession:MP:0004272 term browser browse the term
Definition:anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis
Comment:Note: Basal lamina and lamina reticularis (or of two basal laminae) compose the basement membrane. Thus, in strict sense, the term basement membrane is different from and should not be confused with basal lamina.
Synonyms:exact_synonym: abnormal basement lamina morphology;   basement membrane dysplasia


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abnormal basement membrane morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg1 adhesion G protein-coupled receptor G1 JBrowse link 8 94,974,756 95,014,208 RGD:5509061
G Ahi1 Abelson helper integration site 1 JBrowse link 10 20,952,232 21,080,429 RGD:5509061
G Cav2 caveolin 2 JBrowse link 6 17,281,185 17,289,130 RGD:5509061
G Col13a1 collagen, type XIII, alpha 1 JBrowse link 10 61,838,234 61,979,206 RGD:5509061
G Col17a1 collagen, type XVII, alpha 1 JBrowse link 19 47,646,341 47,692,042 RGD:5509061
G Col18a1 collagen, type XVIII, alpha 1 JBrowse link 10 77,052,178 77,166,530 RGD:5509061
G Col4a1 collagen, type IV, alpha 1 JBrowse link 8 11,198,423 11,312,889 RGD:5509061
G Crppa CDP-L-ribitol pyrophosphorylase A JBrowse link 12 36,380,575 36,689,503 RGD:5509061
G Dag1 dystroglycan 1 JBrowse link 9 108,204,861 108,263,977 RGD:5509061
G Edil3 EGF-like repeats and discoidin I-like domains 3 JBrowse link 13 88,821,472 89,323,225 RGD:5509061
G Emx1 empty spiracles homeobox 1 JBrowse link 6 85,187,931 85,204,463 RGD:5509061
G Flrt3 fibronectin leucine rich transmembrane protein 3 JBrowse link 2 140,658,198 140,671,476 RGD:5509061
G Foxc1 forkhead box C1 JBrowse link 13 31,806,646 31,810,635 RGD:5509061
G Fras1 Fraser extracellular matrix complex subunit 1 JBrowse link 5 96,373,777 96,784,733 RGD:5509061
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano JBrowse link 6 113,067,428 113,077,244 RGD:5509061
G Hspg2 perlecan (heparan sulfate proteoglycan 2) JBrowse link 4 137,468,751 137,570,630 RGD:5509061
G Ilk integrin linked kinase JBrowse link 7 105,736,590 105,742,925 RGD:5509061
G Itga6 integrin alpha 6 JBrowse link 2 71,786,886 71,858,427 RGD:5509061
G Itgb1 integrin beta 1 (fibronectin receptor beta) JBrowse link 8 128,685,654 128,733,579 RGD:5509061
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:5509061
G Lama2 laminin, alpha 2 JBrowse link 10 26,981,285 27,617,191 RGD:5509061
G Lamc1 laminin, gamma 1 JBrowse link 1 153,218,922 153,332,786 RGD:5509061
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) JBrowse link 14 54,431,598 54,442,456 RGD:5509061
G Nid1 nidogen 1 JBrowse link 13 13,437,602 13,512,275 RGD:5509061
G Pdgfrb platelet derived growth factor receptor, beta polypeptide JBrowse link 18 61,045,127 61,085,067 RGD:5509061
G Pomgnt1 protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase JBrowse link 4 116,150,498 116,159,844 RGD:5509061
G Pomt2 protein-O-mannosyltransferase 2 JBrowse link 12 87,106,861 87,147,968 RGD:5509061
G Ric8a RIC8 guanine nucleotide exchange factor A JBrowse link 7 140,857,397 140,863,731 RGD:5509061
G Rtl1 retrotransposon Gaglike 1 JBrowse link 12 109,564,900 109,604,418 RGD:5509061
G Slc31a1 solute carrier family 31, member 1 JBrowse link 4 62,360,583 62,391,769 RGD:5509061
G Spint1 serine protease inhibitor, Kunitz type 1 JBrowse link 2 119,237,360 119,249,535 RGD:5509061
abnormal basal lamina morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) JBrowse link 17 78,200,233 78,376,592 RGD:5509061
G Gas2 growth arrest specific 2 JBrowse link 7 51,861,791 51,995,005 RGD:5509061
G Lama2 laminin, alpha 2 JBrowse link 10 26,981,285 27,617,191 RGD:5509061
G Lama4 laminin, alpha 4 JBrowse link 10 38,965,515 39,110,188 RGD:5509061
G Lamc2 laminin, gamma 2 JBrowse link 1 153,122,756 153,186,447 RGD:5509061
G Pomgnt2 protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2 JBrowse link 9 121,981,606 121,996,053 RGD:5509061
G Reck reversion-inducing-cysteine-rich protein with kazal motifs JBrowse link 4 43,875,521 43,944,806 RGD:5509061
abnormal cochlear basement membrane morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Col4a3 collagen, type IV, alpha 3 JBrowse link 1 82,586,921 82,722,059 RGD:5509061
G Myo7a myosin VIIA JBrowse link 7 98,051,054 98,119,522 RGD:5509061
impaired basement membrane formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adm adrenomedullin JBrowse link 7 110,627,657 110,629,820 RGD:5509061
G Fktn fukutin JBrowse link 4 53,714,107 53,765,785 RGD:5509061
G Flrt3 fibronectin leucine rich transmembrane protein 3 JBrowse link 2 140,658,198 140,671,476 RGD:5509061
G Hspg2 perlecan (heparan sulfate proteoglycan 2) JBrowse link 4 137,468,751 137,570,630 RGD:5509061
G Itgb8 integrin beta 8 JBrowse link 12 119,162,803 119,238,276 RGD:5509061
G Lama4 laminin, alpha 4 JBrowse link 10 38,965,515 39,110,188 RGD:5509061
G Lama5 laminin, alpha 5 JBrowse link 2 180,176,373 180,225,904 RGD:5509061
G Notch1 notch 1 JBrowse link 2 26,457,902 26,503,822 RGD:5509061
G Notch3 notch 3 JBrowse link 17 32,120,820 32,166,896 RGD:5509061
G P4ha1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide JBrowse link 10 59,323,197 59,373,304 RGD:5509061
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 JBrowse link 5 136,987,019 136,996,646 RGD:5509061
G Pomgnt1 protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase JBrowse link 4 116,150,498 116,159,844 RGD:5509061

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Term Annotations click to browse term
  mammalian phenotype 13565
    cellular phenotype 4303
      abnormal extracellular matrix morphology 55
        abnormal basement membrane morphology 47
          abnormal basal lamina morphology 7
          abnormal cochlear basement membrane morphology 2
          impaired basement membrane formation 12
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.