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ONTOLOGY REPORT - ANNOTATIONS


Term:immune system phenotype
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Accession:MP:0005387 term browser browse the term
Definition:the observable morphological and physiological characteristics of the mammalian system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies that are manifested through development and lifespan


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abnormal interferon level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
abnormal lymphocyte morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
abnormal microglial cell activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:12879399
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo RGD:12879399
abnormal response to transplant term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lta lymphotoxin alpha JBrowse link 20 4,851,889 4,854,677 RGD:1580413
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1580395
abnormal spleen B cell follicle morphology term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:7207471
G Ednrbsl endothelin receptor type B, spotting lethal RGD:7207471
abnormal spleen development term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:7207471
G Ednrbsl endothelin receptor type B, spotting lethal RGD:7207471
absent mast cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:5133424
G KitWs KIT proto-oncogene receptor tyrosine kinase; mutant 1 RGD:5133424
athymia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxn1 forkhead box N1 JBrowse link 10 65,621,142 65,634,666 RGD:1300512
brain inflammation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rnaset2 ribonuclease T2 JBrowse link 1 53,174,879 53,192,048 RGD:13781889
G Rnaset2em1Sage ribonuclease T2; CRISPR/Cas9 induced mutant 1, Sage RGD:13781889
decreased B cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7204134
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:7204134
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:7207429
G Rag1em1Ztm recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover RGD:7204131
decreased CD4-positive, alpha beta T cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
decreased CD8-positive, alpha-beta T cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
decreased eosinophil cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased immunoglobulin level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:8696027
decreased leukocyte cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:2316325
decreased lymphocyte cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:13462048
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs RGD:13462048
decreased mature B cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
decreased microglial cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:12879399
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo RGD:12879399
decreased monocyte cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:13792708
G Fhem1 fumarate hydratase; TALEN induced mutant 1 RGD:13792708
decreased NK cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:12910490
G Il15em1Soar interleukin 15; ZFN induced mutant 1, Soar RGD:12910490
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
decreased spleen red pulp amount term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:7207471
G Ednrbsl endothelin receptor type B, spotting lethal RGD:7207471
decreased spleen weight term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il15 interleukin 15 JBrowse link 19 23,542,606 23,624,366 RGD:12910490
G Il15em1Soar interleukin 15; ZFN induced mutant 1, Soar RGD:12910490
decreased splenocyte proliferation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
decreased susceptibility to experimental autoimmune myasthenia gravis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1600670
decreased T cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:12879393
G Atmm1Kyo ATM serine/threonine kinase; ENU induced mutant 1, Kyo RGD:12879393
G Cd247 Cd247 molecule JBrowse link 13 83,996,045 84,071,408 RGD:13442481
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442481
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11566051
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Lepem1Sage leptin; zinc finger nuclease induced mutant1, Sage RGD:12904911
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7204134
RGD:7207429
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:7204134
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:7207429
G Rag1em1Ztm recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover RGD:7204131
decreased thymocyte number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
decreased thymus weight term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:7207471
G Ednrbsl endothelin receptor type B, spotting lethal RGD:7207471
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7207429
G Rag1em1Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:7207429
G Rag1em2Mcwi recombination activating gene 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:7207429
decreased tumor necrosis factor secretion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:12910488
G Tlr4em1Geh toll-like receptor 4; mutation 1, Gregg E. Homanics RGD:12910488
increased double-positive T cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:12879393
G Atmm1Kyo ATM serine/threonine kinase; ENU induced mutant 1, Kyo RGD:12879393
increased leukocyte cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G F8em1Sage coagulation factor VIII, procoagulant component; zinc finger nuclease induced mutant1, Sage RGD:11530071
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:2316657
increased lymphocyte cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:2316657
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:12904914
G Sh2b3em2Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:12904914
increased monocyte cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:12904914
G Sh2b3em2Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:12904914
increased neutrophil cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:11566051
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:2316657
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:12904914
G Sh2b3em2Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 2, Medical College of Wisconsin RGD:12904914
increased regulatory T cell number term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sh2b3 SH2B adaptor protein 3 JBrowse link 12 40,261,990 40,265,757 RGD:13442483
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin RGD:13442483
increased susceptibility to induced arthritis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ncf1 neutrophil cytosolic factor 1 JBrowse link 12 25,497,104 25,506,300 RGD:628543
increased susceptibility to type III hypersensitivity reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:13792592
G Cd59em1Ask CD59 molecule; CRISPR/Cas9 induced mutant1, Ask RGD:13792592
insulitis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifnar1 interferon alpha and beta receptor subunit 1 JBrowse link 11 31,640,407 31,666,839 RGD:12910492
G Ifnar1em1 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 1 RGD:12910492
G Ifnar1em2 interferon alpha and beta receptor subunit 1; CRISPR/Cas9 induced mutant 2 RGD:12910492
lymph node hypoplasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:13628403
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
microgliosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:12879399
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo RGD:12879399
small lymph nodes term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7204134
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:7204134
small spleen term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:7207471
G Ednrbsl endothelin receptor type B, spotting lethal RGD:7207471
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7204134
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:7204134
small thymus term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
G Rag1 recombination activating 1 JBrowse link 3 91,206,394 91,217,491 RGD:7204134
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:7204134
G Rag1em1Ztm recombination activating gene 1; zinc finger nuclease induced mutant 1, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover RGD:7204131
spleen hypoplasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:2316325
G Il2rgem1Ang interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang RGD:13628403
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:8696027
G Rag1em1Ang recombination activating gene 1; zinc finger nuclease induced mutant 1, Ignacio Anegon RGD:13628403
thymus hypoplasia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il2rg interleukin 2 receptor subunit gamma JBrowse link X 71,165,378 71,169,078 RGD:2316325
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:8696027

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  mammalian phenotype 5049
    immune system phenotype 417
      abnormal immune system morphology + 114
      abnormal immune system physiology + 334
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.