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ONTOLOGY REPORT - ANNOTATIONS


Term:increased cardiac muscle contractility
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Accession:MP:0005599 term browser browse the term
Definition:greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms:exact_synonym: increased cardiac muscle contraction
 narrow_synonym: increased fractional shortening (FS);   increased peak of aortic outflow velocity (PAV);   increased velocity of circumferential fiber shortening (Vcfc);   increased velocity of circumferential fibre shortening (Vcfc);   increased ventricular ejection fraction volume
 alt_id: MP:0002973


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increased cardiac muscle contractility term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A1cf APOBEC1 complementation factor JBrowse link 19 31,868,756 31,952,365 RGD:5509061
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 JBrowse link X 164,139,342 164,188,418 RGD:5509061
G Adra1a adrenergic receptor, alpha 1a JBrowse link 14 66,635,251 66,771,240 RGD:5509061
G Adra1b adrenergic receptor, alpha 1b JBrowse link 11 43,774,605 43,901,250 RGD:5509061
G Akap12 A kinase (PRKA) anchor protein (gravin) 12 JBrowse link 10 4,266,329 4,359,471 RGD:5509061
G Ap4e1 adaptor-related protein complex AP-4, epsilon 1 JBrowse link 2 127,008,679 127,069,814 RGD:5509061
G Asph aspartate-beta-hydroxylase JBrowse link 4 9,449,085 9,669,344 RGD:5509061
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide JBrowse link 3 101,576,219 101,604,707 RGD:5509061
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide JBrowse link 1 172,271,709 172,298,064 RGD:5509061
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like JBrowse link 14 66,985,238 67,008,877 RGD:5509061
G Braf Braf transforming gene JBrowse link 6 39,603,231 39,725,658 RGD:5509061
G Cldn12 claudin 12 JBrowse link 5 5,505,015 5,514,976 RGD:5509061
G Csrp3 cysteine and glycine-rich protein 3 JBrowse link 7 48,830,398 48,848,051 RGD:5509061
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 9 54,165,937 54,268,164 RGD:5509061
G Dmd dystrophin, muscular dystrophy JBrowse link X 82,814,664 85,205,050 RGD:5509061
G Dusp8 dual specificity phosphatase 8 JBrowse link 7 142,079,487 142,095,907 RGD:5509061
G Ednrb endothelin receptor type B JBrowse link 14 103,814,615 103,844,508 RGD:5509061
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 JBrowse link 8 27,260,327 27,275,656 RGD:5509061
G Fxyd1 FXYD domain-containing ion transport regulator 1 JBrowse link 7 31,051,678 31,055,873 RGD:5509061
G Fzd8 frizzled class receptor 8 JBrowse link 18 9,212,856 9,216,201 RGD:5509061
G Hdnr Hand2 downstream lncRNA JBrowse link 8 57,332,435 57,354,580 RGD:5509061
G Hprt hypoxanthine guanine phosphoribosyl transferase JBrowse link X 52,988,078 53,021,660 RGD:5509061
G Kdm4a lysine (K)-specific demethylase 4A JBrowse link 4 118,136,957 118,180,090 RGD:5509061
G Klf3 Kruppel-like factor 3 (basic) JBrowse link 5 64,803,521 64,832,901 RGD:5509061
G Klhl29 kelch-like 29 JBrowse link 12 5,077,465 5,375,682 RGD:5509061
G Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:5509061
G Mrps34 mitochondrial ribosomal protein S34 JBrowse link 17 24,895,120 24,896,289 RGD:5509061
G Mtg1 mitochondrial ribosome-associated GTPase 1 JBrowse link 7 140,137,564 140,150,786 RGD:5509061
G Mybpc3 myosin binding protein C, cardiac JBrowse link 2 91,118,114 91,136,516 RGD:5509061
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha JBrowse link 14 54,941,921 54,968,017 RGD:5509061
G Nkx2-5 NK2 homeobox 5 JBrowse link 17 26,838,664 26,844,988 RGD:5509061
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:5509061
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:5509061
G Pax5 paired box 5 JBrowse link 4 44,524,748 44,710,694 RGD:5509061
G Pde4d phosphodiesterase 4D, cAMP specific JBrowse link 13 108,654,177 109,955,969 RGD:5509061
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 12 32,173,397 32,208,677 RGD:5509061
G Pln phospholamban JBrowse link 10 53,337,686 53,345,999 RGD:5509061
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha JBrowse link 14 67,014,056 67,072,471 RGD:5509061
G Prdm4 PR domain containing 4 JBrowse link 10 85,891,964 85,917,152 RGD:5509061
G Prkd1 protein kinase D1 JBrowse link 12 50,341,226 50,649,271 RGD:5509061
G Ptcd1 pentatricopeptide repeat domain 1 JBrowse link 5 145,147,378 145,167,104 RGD:5509061
G Pten phosphatase and tensin homolog JBrowse link 19 32,757,577 32,826,160 RGD:5509061
G Raf1 v-raf-leukemia viral oncogene 1 JBrowse link 6 115,618,569 115,676,635 RGD:5509061
G Rnf10 ring finger protein 10 JBrowse link 5 115,241,770 115,272,921 RGD:5509061
G Rxfp3 relaxin family peptide receptor 3 JBrowse link 15 11,033,717 11,037,968 RGD:5509061
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 3 83,765,750 83,774,314 RGD:5509061
G Sln sarcolipin JBrowse link 9 53,850,251 53,853,849 RGD:5509061
G Tbx3 T-box 3 JBrowse link 5 119,670,534 119,684,724 RGD:5509061
G Tigar Trp53 induced glycolysis regulatory phosphatase JBrowse link 6 127,085,116 127,109,552 RGD:5509061
G Tmem108 transmembrane protein 108 JBrowse link 9 103,482,936 103,761,900 RGD:5509061
G Tnnc1 troponin C, cardiac/slow skeletal JBrowse link 14 31,208,312 31,211,729 RGD:5509061
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:5509061
G Vgll4 vestigial like family member 4 JBrowse link 6 114,860,621 114,970,007 RGD:5509061
increased ventricle muscle contractility term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa6 annexin A6 JBrowse link 11 54,978,953 55,033,471 RGD:5509061
G Arrb1 arrestin, beta 1 JBrowse link 7 99,535,147 99,606,772 RGD:5509061
G Fkbp1b FK506 binding protein 1b JBrowse link 12 4,833,176 4,841,573 RGD:5509061
G Gata5 GATA binding protein 5 JBrowse link 2 180,325,088 180,335,503 RGD:5509061
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:5509061
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:5509061
G Nos1 nitric oxide synthase 1, neuronal JBrowse link 5 117,866,839 117,958,840 RGD:5509061
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:5509061
G Pdc phosducin JBrowse link 1 150,319,417 150,333,906 RGD:5509061
G Plau plasminogen activator, urokinase JBrowse link 14 20,836,662 20,843,388 RGD:5509061
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 JBrowse link 17 81,373,105 81,738,387 RGD:5509061

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 14688
    cardiovascular system phenotype 3224
      abnormal cardiovascular system physiology 1898
        abnormal cardiac muscle contractility 347
          increased cardiac muscle contractility 62
            increased ventricle muscle contractility 11
Path 2
Term Annotations click to browse term
  mammalian phenotype 14688
    muscle phenotype 1734
      abnormal muscle physiology 1099
        abnormal muscle contractility 488
          abnormal cardiac muscle contractility 347
            increased cardiac muscle contractility 62
              increased ventricle muscle contractility 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.