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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal cell physiology
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Accession:MP:0005621 term browser browse the term
Definition:any functional anomaly of the vital processes of the cell


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abnormal apoptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone IDA RGD PMID:11908464 RGD:704423 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
abnormal cellular respiration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myc MYC proto-oncogene, bHLH transcription factor IMP RGD PMID:22842522 RGD:7207891 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
abnormal mitophagy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lamp2 lysosomal-associated membrane protein 2 IMP in hemizygote mutant male (LAMP2y/-) RGD PMID:28124283 RGD:13703118 NCBI chr  X:124,722,628...124,766,079
Ensembl chr  X:124,722,628...124,766,044
JBrowse link
G Lamp2em1 lysosomal-associated membrane protein 2; TALEN induced mutant1 IMP in hemizygote mutant male (LAMP2y/-) RGD PMID:28124283 RGD:13703118
abnormal retinal apoptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hras HRas proto-oncogene, GTPase IDA RGD PMID:14988264 RGD:1358731 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
decreased fibroblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myc MYC proto-oncogene, bHLH transcription factor IMP RGD PMID:22842522 RGD:7207891 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
decreased neuron apoptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednrb endothelin receptor type B IMP RGD PMID:18683040 RGD:4892578 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
decreased T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd247 Cd247 molecule IMP compared to wild-type RGD PMID:24343121 RGD:13442481 NCBI chr13:83,996,045...84,071,408
Ensembl chr13:83,996,080...84,071,400
JBrowse link
G Cd247em1Mcwi Cd247 molecule; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:24343121 RGD:13442481
impaired acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin IMP RGD PMID:28859281 RGD:13464336 NCBI chr 7:130,541,320...130,548,356
Ensembl chr 7:130,542,202...130,548,356
JBrowse link
increased apoptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 IDA RGD PMID:11895366 RGD:1304239 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798
JBrowse link
increased cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 IDA RGD PMID:12668975 RGD:704417 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ednrb endothelin receptor type B IMP RGD PMID:18683040 RGD:4892578 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Lpin1 lipin 1 onset IMP RGD PMID:21715287 RGD:38599010 NCBI chr 6:41,796,214...41,905,149
Ensembl chr 6:41,799,749...41,870,046
JBrowse link
increased cellular glucose import term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Myc MYC proto-oncogene, bHLH transcription factor IMP RGD PMID:22842522 RGD:7207891 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
increased T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Themis thymocyte selection associated IMP RGD PMID:22275874 RGD:38599149 NCBI chr 1:17,152,973...17,378,225
Ensembl chr 1:17,171,631...17,378,047
JBrowse link
oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP DNA:deletion:exon: RGD PMID:28007901 RGD:12879399 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atmem1Kyo ATM serine/threonine kinase; ZFN induced mutant 1, Kyo IMP RGD PMID:28007901 RGD:12879399
G Nox4 NADPH oxidase 4 severity IMP RGD PMID:26644237 RGD:11085830 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Nox4em2Mcwi NADPH oxidase 4; zinc finger nuclease induced mutant 2, Medical College of Wisconsin severity IMP RGD PMID:26644237 RGD:11085830

Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 4973
    cellular phenotype 71
      abnormal cell physiology 57
        abnormal DNA repair + 0
        abnormal DNA replication 0
        abnormal DNA-templated transcription 0
        abnormal autophagy + 3
        abnormal cell adhesion + 0
        abnormal cell cycle + 0
        abnormal cell death + 14
        abnormal cell differentiation + 0
        abnormal cell motility + 2
        abnormal cell proliferation + 15
        abnormal cellular cholesterol metabolism + 1
        abnormal cellular glucose uptake + 10
        abnormal cellular replicative senescence + 0
        abnormal cellular respiration + 1
        abnormal chromosome stability + 0
        abnormal cilium physiology + 0
        abnormal endoplasmic reticulum physiology + 0
        abnormal epigenetic regulation of gene expression + 0
        abnormal fibroblast physiology + 1
        abnormal germ cell physiology + 0
        abnormal hepatoblast physiology + 0
        abnormal lipid oxidation + 2
        abnormal lysosome physiology + 0
        abnormal mitochondrial physiology + 1
        abnormal osteoblast physiology + 0
        abnormal peroxisome physiology 0
        abnormal redox activity + 11
        abnormal translation + 0
        abnormal vesicle-mediated transport + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.