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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased testis tumor incidence
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Accession:MP:0006262 term browser browse the term
Definition:greater than the expected number of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass, occurring in a specific population in a given time period
Synonyms:exact_synonym: increased testicular tumor incidence;   increased testicular tumour incidence;   increased testis tumour incidence
 related_synonym: testis tumor;   testis tumour


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increased testis tumor incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amh anti-Mullerian hormone IAGP MGI PMID:8895659 NCBI chr10:80,805,240...80,807,679
Ensembl chr10:80,805,243...80,807,648
JBrowse link
G Amhr2 anti-Mullerian hormone type 2 receptor IAGP MGI PMID:8895659, PMID:17967875, PMID:19237610, PMID:21860425 NCBI chr15:102,445,002...102,454,640
Ensembl chr15:102,445,367...102,454,633
JBrowse link
G Ar androgen receptor IAGP MGI PMID:18401008 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IAGP MGI PMID:17409423 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B IAGP MGI PMID:10880462 NCBI chr 4:89,306,289...89,311,032
Ensembl chr 4:89,306,299...89,311,039
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C IAGP MGI PMID:10880462, PMID:17409423 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 IAGP MGI PMID:19237610, PMID:21860425 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Dnd1 DND microRNA-mediated repression inhibitor 1 IAGP MGI PMID:3860691, PMID:20736371, PMID:23773267 NCBI chr18:36,763,671...36,766,214
Ensembl chr18:36,763,671...36,766,214
JBrowse link
G Esr1 estrogen receptor 1 (alpha) IAGP MGI PMID:12855748 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) IAGP MGI PMID:12855748 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 IAGP MGI PMID:18552834 NCBI chr10:81,366,879...81,378,370
Ensembl chr10:81,366,222...81,378,516
JBrowse link
G Inha inhibin alpha IAGP MGI PMID:8895659, PMID:12855748, PMID:17652186 NCBI chr 1:75,507,077...75,510,366
Ensembl chr 1:75,507,077...75,510,366
JBrowse link
G Kras Kirsten rat sarcoma viral oncogene homolog IAGP MGI PMID:21860425 NCBI chr 6:145,216,699...145,250,420
Ensembl chr 6:145,216,699...145,250,239
JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP MGI PMID:12819299, PMID:17409423, PMID:19620250 NCBI chr19:6,334,979...6,340,894
Ensembl chr19:6,334,979...6,340,891
JBrowse link
G Ndrg2 N-myc downstream regulated gene 2 IAGP MGI PMID:24569712 NCBI chr14:51,905,271...51,914,004
Ensembl chr14:51,905,271...51,914,158
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 IAGP MGI PMID:11564714 NCBI chr  X:86,191,775...86,195,947
Ensembl chr  X:86,191,764...86,195,947
JBrowse link
G Pten phosphatase and tensin homolog IAGP MGI PMID:19237610, PMID:21860425 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Sf1 splicing factor 1 IAGP MGI PMID:20736371 NCBI chr19:6,363,673...6,378,038
Ensembl chr19:6,363,690...6,378,030
JBrowse link
G Smad1 SMAD family member 1 IAGP MGI PMID:17967875 NCBI chr 8:79,338,395...79,399,428
Ensembl chr 8:79,338,395...79,399,518
JBrowse link
G Smad5 SMAD family member 5 IAGP MGI PMID:17967875 NCBI chr13:56,703,010...56,742,378
Ensembl chr13:56,703,010...56,742,377
JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 IAGP MGI PMID:20739274 NCBI chr11:30,099,395...30,268,384
Ensembl chr11:30,099,395...30,268,175
JBrowse link
increased Leydig cell tumor incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amhr2 anti-Mullerian hormone type 2 receptor IAGP MGI PMID:8895659 NCBI chr15:102,445,002...102,454,640
Ensembl chr15:102,445,367...102,454,633
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) IAGP MGI PMID:11507077 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C IAGP MGI PMID:17409423 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Inha inhibin alpha IAGP MGI PMID:8895659 NCBI chr 1:75,507,077...75,510,366
Ensembl chr 1:75,507,077...75,510,366
JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP MGI PMID:12819299, PMID:17044021, PMID:17409423 NCBI chr19:6,334,979...6,340,894
Ensembl chr19:6,334,979...6,340,891
JBrowse link
G Nbn nibrin IAGP MGI PMID:14612522 NCBI chr 4:15,957,587...15,992,589
Ensembl chr 4:15,957,925...15,992,589
JBrowse link
increased testicular teratoma incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cop1 COP1, E3 ubiquitin ligase IAGP MGI PMID:21403399 NCBI chr 1:159,232,156...159,354,872
Ensembl chr 1:159,232,320...159,347,640
JBrowse link
G Dnd1 DND microRNA-mediated repression inhibitor 1 IAGP MGI PMID:3860691, PMID:4692863 NCBI chr18:36,763,671...36,766,214
Ensembl chr18:36,763,671...36,766,214
JBrowse link
G Kitl kit ligand IEA MGI NCBI chr10:100,015,615...100,100,416
Ensembl chr10:100,015,630...100,100,416
JBrowse link
G Ptch1 patched 1 IAGP MGI PMID:16849540 NCBI chr13:63,508,328...63,573,460
Ensembl chr13:63,508,328...63,573,598
JBrowse link
G Ptch2 patched 2 IAGP MGI PMID:16849540 NCBI chr 4:117,096,056...117,116,101
Ensembl chr 4:117,096,075...117,116,101
JBrowse link
G Rb1 RB transcriptional corepressor 1 IAGP MGI PMID:16227443 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
G Trp53 transformation related protein 53 IAGP MGI PMID:16227443 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 14746
    endocrine/exocrine gland phenotype 2788
      abnormal gland morphology 2567
        increased gland tumor incidence 340
          increased testis tumor incidence 34
            increased Leydig cell tumor incidence 6
            increased testicular teratoma incidence 7
Path 2
Term Annotations click to browse term
  mammalian phenotype 14746
    neoplasm 1236
      altered tumor susceptibility 1108
        abnormal tumor incidence 1090
          abnormal organ/body region tumor incidence 828
            increased organ/body region tumor incidence 795
              increased reproductive system tumor incidence 125
                increased gonad tumor incidence 86
                  increased testis tumor incidence 34
                    increased Leydig cell tumor incidence 6
                    increased testicular teratoma incidence 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.