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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal follicular dendritic cell physiology
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Accession:MP:0008197 term browser browse the term
Definition:abnormal function of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response
Comment:Annotations to this cell type have been erroneously made to dendritic cell morphology. These are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response. They are not derived from the hematopoietic lineage. Due to its unique lineage and distinct function (B cell vs. T cell presentation), this is NOT a type of dendritic cell.


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  mammalian phenotype 4973
    immune system phenotype 429
      abnormal immune system physiology 348
        abnormal immune cell physiology 38
          abnormal follicular dendritic cell physiology 0
            abnormal follicular dendritic cell antigen presentation 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.