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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:increased Leydig cell tumor incidence
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Accession:MP:0009592 term browser browse the term
Definition:greater than the expected number of rare testicular tumors of the male gonadal interstitium, occurring in a specific population in a given time period; Leydig cell tumors are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur
Synonyms:exact_synonym: increased Leydig cell tumour incidence;   interstitial cell tumor of testis;   interstitial cell tumour of testis
 related_synonym: Leydig cell tumor;   Leydig cell tumour


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increased Leydig cell tumor incidence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amhr2 anti-Mullerian hormone type 2 receptor IAGP MGI PMID:8895659 NCBI chr15:102,445,002...102,454,640
Ensembl chr15:102,445,367...102,454,633
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) IAGP MGI PMID:11507077 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2c cyclin dependent kinase inhibitor 2C IAGP MGI PMID:17409423 NCBI chr 4:109,660,876...109,666,756
Ensembl chr 4:109,660,876...109,667,189
JBrowse link
G Inha inhibin alpha IAGP MGI PMID:8895659 NCBI chr 1:75,507,077...75,510,366
Ensembl chr 1:75,507,077...75,510,366
JBrowse link
G Men1 multiple endocrine neoplasia 1 IAGP MGI PMID:12819299, PMID:17044021, PMID:17409423 NCBI chr19:6,334,979...6,340,894
Ensembl chr19:6,334,979...6,340,891
JBrowse link
G Nbn nibrin IAGP MGI PMID:14612522 NCBI chr 4:15,957,587...15,992,589
Ensembl chr 4:15,957,925...15,992,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 14921
    endocrine/exocrine gland phenotype 2818
      abnormal gland morphology 2598
        increased gland tumor incidence 340
          increased testis tumor incidence 34
            increased Leydig cell tumor incidence 6
Path 2
Term Annotations click to browse term
  mammalian phenotype 14921
    neoplasm 1239
      altered tumor susceptibility 1110
        abnormal tumor incidence 1092
          abnormal organ/body region tumor incidence 830
            increased organ/body region tumor incidence 796
              increased reproductive system tumor incidence 125
                increased gonad tumor incidence 86
                  increased testis tumor incidence 34
                    increased Leydig cell tumor incidence 6
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.