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ONTOLOGY REPORT - ANNOTATIONS


Term:abnormal uterine spiral artery remodeling
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Accession:MP:0012727 term browser browse the term
Definition:any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor
Synonyms:exact_synonym: abnormal decidual spiral artery remodeling;   abnormal endometrial spiral artery remodeling;   abnormal maternal spiral artery remodeling;   abnormal uterine spiral artery modification


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abnormal uterine spiral artery remodeling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mmp12 matrix metallopeptidase 12 JBrowse link 8 5,594,717 5,616,494 RGD:12910498

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Term Annotations click to browse term
  mammalian phenotype 4930
    reproductive system phenotype 72
      abnormal reproductive system physiology 29
        abnormal female reproductive system physiology 8
          abnormal uterus physiology 1
            abnormal postimplantation uterine environment 1
              abnormal uterine angiogenesis 1
                abnormal uterine spiral artery remodeling 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 4930
    reproductive system phenotype 72
      abnormal reproductive system physiology 29
        abnormal female reproductive system physiology 8
          abnormal pregnancy 6
            abnormal uterine environment 1
              abnormal postimplantation uterine environment 1
                abnormal uterine angiogenesis 1
                  abnormal uterine spiral artery remodeling 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.