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ONTOLOGY REPORT - ANNOTATIONS


Term:abnormal IgE level
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Accession:MP:0020173 term browser browse the term
Definition:deviation from the normal levels of immunoglobulin class E level


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decreased IgE level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aicda activation-induced cytidine deaminase JBrowse link 6 122,553,809 122,564,180 RGD:5509061
G Arhgef4 Rho guanine nucleotide exchange factor (GEF) 4 JBrowse link 1 34,677,949 34,812,754 RGD:5509061
G Batf basic leucine zipper transcription factor, ATF-like JBrowse link 12 85,686,720 85,709,087 RGD:5509061
G Bcl3 B cell leukemia/lymphoma 3 JBrowse link 7 19,808,462 19,822,824 RGD:5509061
G C3ar1 complement component 3a receptor 1 JBrowse link 6 122,847,140 122,856,157 RGD:5509061
G Card11 caspase recruitment domain family, member 11 JBrowse link 5 140,872,999 141,000,596 RGD:5509061
G Ccr4 chemokine (C-C motif) receptor 4 JBrowse link 9 114,490,316 114,505,476 RGD:5509061
G Ccr6 chemokine (C-C motif) receptor 6 JBrowse link 17 8,236,041 8,258,519 RGD:5509061
G Cd19 CD19 antigen JBrowse link 7 126,408,448 126,415,148 RGD:5509061
G Cd40 CD40 antigen JBrowse link 2 165,055,614 165,071,654 RGD:5509061
G Cd40lg CD40 ligand JBrowse link X 57,212,143 57,224,042 RGD:5509061
G Cd79a CD79A antigen (immunoglobulin-associated alpha) JBrowse link 7 24,897,497 24,901,858 RGD:5509061
G Chil1 chitinase-like 1 JBrowse link 1 134,182,156 134,190,031 RGD:5509061
G Diaph1 diaphanous related formin 1 JBrowse link 18 37,843,601 37,935,622 RGD:5509061
G Dock2 dedicator of cyto-kinesis 2 JBrowse link 11 34,226,815 34,783,905 RGD:5509061
G Ecm1 extracellular matrix protein 1 JBrowse link 3 95,734,147 95,739,876 RGD:5509061
G F2rl1 coagulation factor II (thrombin) receptor-like 1 JBrowse link 13 95,511,718 95,525,240 RGD:5509061
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:5509061
G Fnip1 folliculin interacting protein 1 JBrowse link 11 54,438,107 54,518,241 RGD:5509061
G Fpr2 formyl peptide receptor 2 JBrowse link 17 17,887,824 17,893,952 RGD:5509061
G Fyn Fyn proto-oncogene JBrowse link 10 39,369,743 39,565,381 RGD:5509061
G Gata3 GATA binding protein 3 JBrowse link 2 9,857,078 9,887,953 RGD:5509061
G Grhl3 grainyhead like transcription factor 3 JBrowse link 4 135,541,887 135,573,632 RGD:5509061
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano JBrowse link 6 113,067,428 113,077,244 RGD:5509061
G Hmgn5 high-mobility group nucleosome binding domain 5 JBrowse link X 109,004,537 109,013,380 RGD:5509061
G Hoxc4 homeobox C4 JBrowse link 15 103,018,097 103,036,856 RGD:5509061
G Hrh4 histamine receptor H4 JBrowse link 18 13,006,982 13,023,701 RGD:5509061
G Icos inducible T cell co-stimulator JBrowse link 1 60,960,773 61,000,322 RGD:5509061
G Icosl icos ligand JBrowse link 10 78,069,368 78,079,525 RGD:5509061
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:5509061
G Igh immunoglobulin heavy chain complex JBrowse link 12 113,258,768 116,009,954 RGD:5509061
G Igh-7 immunoglobulin heavy chain 7 (heavy chain of IgE) RGD:5509061
G Igha immunoglobulin heavy constant alpha JBrowse link 12 113,256,204 113,260,236 RGD:5509061
G Ighd immunoglobulin heavy constant delta JBrowse link 12 113,407,535 113,416,324 RGD:5509061
G Ighe Immunoglobulin heavy constant epsilon JBrowse link 12 113,269,263 113,273,248 RGD:5509061
G Ighm immunoglobulin heavy constant mu JBrowse link 12 113,418,826 113,422,730 RGD:5509061
G Ikbkb inhibitor of kappaB kinase beta JBrowse link 8 22,659,205 22,706,589 RGD:5509061
G Ikzf3 IKAROS family zinc finger 3 JBrowse link 11 98,464,610 98,546,031 RGD:5509061
G Il13 interleukin 13 JBrowse link 11 53,631,323 53,634,702 RGD:5509061
G Il13ra1 interleukin 13 receptor, alpha 1 JBrowse link X 36,112,108 36,171,262 RGD:5509061
G Il17a interleukin 17A JBrowse link 1 20,730,905 20,734,496 RGD:5509061
G Il17rb interleukin 17 receptor B JBrowse link 14 29,996,168 30,008,896 RGD:5509061
G Il18 interleukin 18 JBrowse link 9 50,554,700 50,581,841 RGD:5509061
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 1 40,404,864 40,465,418 RGD:5509061
G Il21r interleukin 21 receptor JBrowse link 7 125,603,252 125,634,397 RGD:5509061
G Il2rg interleukin 2 receptor, gamma chain JBrowse link X 101,264,385 101,268,255 RGD:5509061
G Il33 interleukin 33 JBrowse link 19 29,925,113 29,960,718 RGD:5509061
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:5509061
G Il4ra interleukin 4 receptor, alpha JBrowse link 7 125,552,271 125,579,474 RGD:5509061
G Il5 interleukin 5 JBrowse link 11 53,720,794 53,725,103 RGD:5509061
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:5509061
G Il9 interleukin 9 JBrowse link 13 56,479,277 56,482,257 RGD:5509061
G Itfg2 integrin alpha FG-GAP repeat containing 2 JBrowse link 6 128,409,047 128,424,927 RGD:5509061
G Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A JBrowse link 10 51,490,898 51,496,613 RGD:5509061
G Lmbr1l limb region 1 like JBrowse link 15 98,903,918 98,918,098 RGD:5509061
G Ltb4r1 leukotriene B4 receptor 1 JBrowse link 14 55,765,962 55,768,492 RGD:5509061
G Ltbr lymphotoxin B receptor JBrowse link 6 125,306,571 125,313,885 RGD:5509061
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 4 3,678,068 3,791,612 RGD:5509061
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 11 103,219,764 103,267,401 RGD:5509061
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 18 4,331,325 4,352,953 RGD:5509061
G Mlh1 mutL homolog 1 JBrowse link 9 111,228,228 111,271,786 RGD:5509061
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:5509061
G Msh6 mutS homolog 6 JBrowse link 17 87,975,050 87,990,892 RGD:5509061
G Mtmr4 myotubularin related protein 4 JBrowse link 11 87,591,954 87,616,302 RGD:5509061
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 JBrowse link 18 80,606,205 80,713,071 RGD:5509061
G Nfil3 nuclear factor, interleukin 3, regulated JBrowse link 13 52,967,209 52,982,878 RGD:5509061
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:5509061
G P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 JBrowse link 7 100,937,630 100,975,498 RGD:5509061
G Pla2g10 phospholipase A2, group X JBrowse link 16 13,715,057 13,731,094 RGD:5509061
G Pou2af1 POU domain, class 2, associating factor 1 JBrowse link 9 51,213,690 51,240,079 RGD:5509061
G Ptgdr2 prostaglandin D2 receptor 2 JBrowse link 19 10,924,519 10,942,511 RGD:5509061
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 1 138,062,859 138,175,756 RGD:5509061
G Rac2 Rac family small GTPase 2 JBrowse link 15 78,559,169 78,572,783 RGD:5509061
G Rad50 RAD50 double strand break repair protein JBrowse link 11 53,649,519 53,707,319 RGD:5509061
G Rel reticuloendotheliosis oncogene JBrowse link 11 23,736,847 23,770,969 RGD:5509061
G Rxfp2 relaxin/insulin-like family peptide receptor 2 JBrowse link 5 150,018,675 150,082,550 RGD:5509061
G Sh2d1a SH2 domain containing 1A JBrowse link X 42,502,565 42,522,097 RGD:5509061
G Sharpin SHANK-associated RH domain interacting protein JBrowse link 15 76,347,040 76,351,110 RGD:5509061
G Slc39a10 solute carrier family 39 (zinc transporter), member 10 JBrowse link 1 46,807,544 46,925,776 RGD:5509061
G Stat6 signal transducer and activator of transcription 6 JBrowse link 10 127,642,955 127,660,987 RGD:5509061
G Swap70 SWA-70 protein JBrowse link 7 110,221,703 110,283,506 RGD:5509061
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 10 7,905,648 7,956,255 RGD:5509061
G Tab3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 JBrowse link X 85,573,854 85,634,469 RGD:5509061
G Tcrb T cell receptor beta chain JBrowse link 6 40,891,296 41,558,371 RGD:5509061
G Tcrd T cell receptor delta chain JBrowse link 14 53,946,073 54,159,198 RGD:5509061
G Tg thyroglobulin JBrowse link 15 66,670,754 66,850,721 RGD:5509061
G Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b JBrowse link 11 61,126,283 61,153,170 RGD:5509061
G Trip10 thyroid hormone receptor interactor 10 JBrowse link 17 57,233,220 57,263,697 RGD:5509061
G Tslp thymic stromal lymphopoietin JBrowse link 18 32,815,383 32,819,799 RGD:5509061
G Vipr2 vasoactive intestinal peptide receptor 2 JBrowse link 12 116,077,420 116,148,637 RGD:5509061
G Zfp760 zinc finger protein 760 JBrowse link 17 21,707,430 21,725,636 RGD:5509061
increased IgE level term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:5509061
G Adam17 a disintegrin and metallopeptidase domain 17 JBrowse link 12 21,323,509 21,373,632 RGD:5509061
G Asf1b anti-silencing function 1B histone chaperone JBrowse link 8 83,955,694 83,970,195 RGD:5509061
G Bcl10 B cell leukemia/lymphoma 10 JBrowse link 3 145,924,262 145,934,366 RGD:5509061
G Bhlhe40 basic helix-loop-helix family, member e40 JBrowse link 6 108,660,629 108,666,925 RGD:5509061
G Blk B lymphoid kinase JBrowse link 14 63,372,837 63,417,187 RGD:5509061
G Btk Bruton agammaglobulinemia tyrosine kinase JBrowse link X 134,542,334 134,583,628 RGD:5509061
G Cabin1 calcineurin binding protein 1 JBrowse link 10 75,646,110 75,764,357 RGD:5509061
G Card11 caspase recruitment domain family, member 11 JBrowse link 5 140,872,999 141,000,596 RGD:5509061
G Casp8 caspase 8 JBrowse link 1 58,795,233 58,847,503 RGD:5509061
G Cbfb core binding factor beta JBrowse link 8 105,170,674 105,217,989 RGD:5509061
G Ccr4 chemokine (C-C motif) receptor 4 JBrowse link 9 114,490,316 114,505,476 RGD:5509061
G Ccr7 chemokine (C-C motif) receptor 7 JBrowse link 11 99,144,199 99,155,077 RGD:5509061
G Cd19 CD19 antigen JBrowse link 7 126,408,448 126,415,148 RGD:5509061
G Col17a1 collagen, type XVII, alpha 1 JBrowse link 19 47,646,341 47,692,042 RGD:5509061
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) JBrowse link 11 54,247,270 54,249,899 RGD:5509061
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 1 60,909,025 60,915,832 RGD:5509061
G Ctse cathepsin E JBrowse link 1 131,638,314 131,675,507 RGD:5509061
G Cxcr2 chemokine (C-X-C motif) receptor 2 JBrowse link 1 74,153,994 74,161,246 RGD:5509061
G Dck deoxycytidine kinase JBrowse link 5 88,765,013 88,783,277 RGD:5509061
G Dock2 dedicator of cyto-kinesis 2 JBrowse link 11 34,226,815 34,783,905 RGD:5509061
G Dsg3 desmoglein 3 JBrowse link 18 20,510,274 20,541,310 RGD:5509061
G Dsg4 desmoglein 4 JBrowse link 18 20,436,175 20,471,821 RGD:5509061
G Ebi3 Epstein-Barr virus induced gene 3 JBrowse link 17 55,952,623 55,957,022 RGD:5509061
G Efhd2 EF hand domain containing 2 JBrowse link 4 141,858,142 141,874,920 RGD:5509061
G Egfr epidermal growth factor receptor JBrowse link 11 16,752,203 16,913,907 RGD:5509061
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 JBrowse link 10 24,773,814 24,836,195 RGD:5509061
G Fas Fas (TNF receptor superfamily member 6) JBrowse link 19 34,290,647 34,327,775 RGD:5509061
G Fasl Fas ligand (TNF superfamily, member 6) JBrowse link 1 161,780,691 161,788,495 RGD:5509061
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide JBrowse link 1 171,229,572 171,234,349 RGD:5509061
G Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide JBrowse link 8 3,680,280 3,694,174 RGD:5509061
G Fgfr1 fibroblast growth factor receptor 1 JBrowse link 8 25,518,759 25,575,718 RGD:5509061
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 7 130,162,451 130,266,808 RGD:5509061
G Flg filaggrin JBrowse link 3 93,273,546 93,293,689 RGD:5509061
G Foxp3 forkhead box P3 JBrowse link X 7,579,676 7,595,243 RGD:5509061
G Gt(ROSA)26Sor gene trap ROSA 26, Philippe Soriano JBrowse link 6 113,067,428 113,077,244 RGD:5509061
G Ifit2 interferon-induced protein with tetratricopeptide repeats 2 JBrowse link 19 34,550,550 34,576,534 RGD:5509061
G Ifitm1 interferon induced transmembrane protein 1 JBrowse link 7 140,967,429 140,969,827 RGD:5509061
G Ifng interferon gamma JBrowse link 10 118,441,046 118,445,894 RGD:5509061
G Igh immunoglobulin heavy chain complex JBrowse link 12 113,258,768 116,009,954 RGD:5509061
G Igh-7 immunoglobulin heavy chain 7 (heavy chain of IgE) RGD:5509061
G Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) JBrowse link 12 113,326,541 113,330,523 RGD:5509061
G Ikzf3 IKAROS family zinc finger 3 JBrowse link 11 98,464,610 98,546,031 RGD:5509061
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:5509061
G Il13ra2 interleukin 13 receptor, alpha 2 JBrowse link X 147,383,478 147,429,192 RGD:5509061
G Il21 interleukin 21 JBrowse link 3 37,222,759 37,232,636 RGD:5509061
G Il21r interleukin 21 receptor JBrowse link 7 125,603,252 125,634,397 RGD:5509061
G Il25 interleukin 25 JBrowse link 14 54,932,695 54,935,837 RGD:5509061
G Il27ra interleukin 27 receptor, alpha JBrowse link 8 84,030,286 84,042,600 RGD:5509061
G Il2rb interleukin 2 receptor, beta chain JBrowse link 15 78,479,256 78,511,621 RGD:5509061
G Il31ra interleukin 31 receptor A JBrowse link 13 112,521,931 112,580,732 RGD:5509061
G Il4ra interleukin 4 receptor, alpha JBrowse link 7 125,552,271 125,579,474 RGD:5509061
G Il6st interleukin 6 signal transducer JBrowse link 13 112,464,070 112,506,860 RGD:5509061
G Itch itchy, E3 ubiquitin protein ligase JBrowse link 2 155,133,481 155,226,855 RGD:5509061
G Itgb2 integrin beta 2 JBrowse link 10 77,530,329 77,565,708 RGD:5509061
G Itk IL2 inducible T cell kinase JBrowse link 11 46,325,148 46,389,515 RGD:5509061
G Jak3 Janus kinase 3 JBrowse link 8 71,676,383 71,690,577 RGD:5509061
G Junb jun B proto-oncogene JBrowse link 8 84,976,909 84,978,748 RGD:5509061
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 5 75,574,987 75,656,722 RGD:5509061
G Klf2 Kruppel-like factor 2 (lung) JBrowse link 8 72,319,062 72,321,654 RGD:5509061
G Kprp keratinocyte expressed, proline-rich JBrowse link 3 92,823,074 92,827,247 RGD:5509061
G Lat linker for activation of T cells JBrowse link 7 126,363,827 126,369,705 RGD:5509061
G Lax1 lymphocyte transmembrane adaptor 1 JBrowse link 1 133,679,017 133,693,022 RGD:5509061
G Lcp2 lymphocyte cytosolic protein 2 JBrowse link 11 34,046,928 34,092,281 RGD:5509061
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:5509061
G Lpar2 lysophosphatidic acid receptor 2 JBrowse link 8 69,822,565 69,831,102 RGD:5509061
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 4 3,678,068 3,791,612 RGD:5509061
G Mmp9 matrix metallopeptidase 9 JBrowse link 2 164,940,326 164,955,850 RGD:5509061
G Myd88 myeloid differentiation primary response gene 88 JBrowse link 9 119,335,934 119,340,018 RGD:5509061
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 JBrowse link 2 168,476,410 168,601,657 RGD:5509061
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 JBrowse link 3 135,584,655 135,691,969 RGD:5509061
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha JBrowse link 12 55,489,409 55,492,647 RGD:5509061
G Nfkbiz nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta JBrowse link 16 55,811,375 55,838,954 RGD:5509061
G Nipal3 NIPA-like domain containing 3 JBrowse link 4 135,442,805 135,494,972 RGD:5509061
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 11 71,091,197 71,144,969 RGD:5509061
G Pigr polymeric immunoglobulin receptor JBrowse link 1 130,826,684 130,852,249 RGD:5509061
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 4 149,649,168 149,702,566 RGD:5509061
G Pld4 phospholipase D family, member 4 JBrowse link 12 112,760,446 112,768,986 RGD:5509061
G Ppia peptidylprolyl isomerase A JBrowse link 11 6,415,867 6,419,817 RGD:5509061
G Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 JBrowse link 18 77,794,550 77,882,879 RGD:5509061
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) JBrowse link 3 103,856,575 103,912,252 RGD:5509061
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 JBrowse link 5 130,171,819 130,214,342 RGD:5509061
G Rag1 recombination activating 1 JBrowse link 2 101,638,252 101,649,532 RGD:5509061
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 2 117,279,983 117,342,877 RGD:5509061
G Relb avian reticuloendotheliosis viral (v-rel) oncogene related B JBrowse link 7 19,606,217 19,629,438 RGD:5509061
G Retnla resistin like alpha JBrowse link 16 48,842,609 48,844,461 RGD:5509061
G Rora RAR-related orphan receptor alpha JBrowse link 9 68,653,404 69,388,246 RGD:5509061
G Runx3 runt related transcription factor 3 JBrowse link 4 135,120,645 135,177,990 RGD:5509061
G Sema4b sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B JBrowse link 7 80,186,870 80,226,646 RGD:5509061
G Siae sialic acid acetylesterase JBrowse link 9 37,613,821 37,648,258 RGD:5509061
G Sox9 SRY (sex determining region Y)-box 9 JBrowse link 11 112,782,210 112,787,757 RGD:5509061
G Stat6 signal transducer and activator of transcription 6 JBrowse link 10 127,642,955 127,660,987 RGD:5509061
G Stk4 serine/threonine kinase 4 JBrowse link 2 164,074,113 164,155,524 RGD:5509061
G Tcra T cell receptor alpha chain JBrowse link 14 52,427,967 54,224,198 RGD:5509061
G Tg thyroglobulin JBrowse link 15 66,670,754 66,850,721 RGD:5509061
G Tmem219 transmembrane protein 219 JBrowse link 7 126,886,219 126,928,821 RGD:5509061
G Tmem79 transmembrane protein 79 JBrowse link 3 88,328,653 88,334,433 RGD:5509061
G Tnfrsf21 tumor necrosis factor receptor superfamily, member 21 JBrowse link 17 43,016,555 43,089,188 RGD:5509061
G Tnip1 TNFAIP3 interacting protein 1 JBrowse link 11 54,910,787 54,962,956 RGD:5509061
G Traf3ip2 TRAF3 interacting protein 2 JBrowse link 10 39,612,934 39,655,307 RGD:5509061
G Was Wiskott-Aldrich syndrome JBrowse link X 8,081,466 8,090,491 RGD:5509061
G Wipf1 WAS/WASL interacting protein family, member 1 JBrowse link 2 73,429,610 73,529,487 RGD:5509061
G Zap70 zeta-chain (TCR) associated protein kinase JBrowse link 1 36,761,798 36,782,821 RGD:5509061

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 14683
    immune system phenotype 4496
      abnormal immune system physiology 3123
        abnormal humoral immune response 711
          abnormal immunoglobulin level 657
            abnormal IgE level 188
              decreased IgE level 98
              increased IgE level 111
Path 2
Term Annotations click to browse term
  mammalian phenotype 14683
    immune system phenotype 4496
      abnormal immune system physiology 3123
        abnormal immune cell physiology 1682
          abnormal leukocyte physiology 1646
            abnormal lymphocyte physiology 1233
              abnormal B cell physiology 785
                abnormal immunoglobulin level 657
                  abnormal IgE level 188
                    decreased IgE level 98
                    increased IgE level 111
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.