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ONTOLOGY REPORT - ANNOTATIONS


Term:Wnt signaling pathway
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Accession:PW:0000008 term browser browse the term
Definition:The secreted glycoproteins of the Wnt family regulate a wide spectrum of developmental processes and they are also playing important roles in the adult organism. Deregulation of Wnt cascades has oncogenic effects and is responsible for tumorigenesis in adults.
Synonyms:related_synonym: KEGG:04310


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Wnt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CDK15 cyclin dependent kinase 15 JBrowse link 2B 207,198,906 207,304,029 RGD:9068941
G WNT1 Wnt family member 1 JBrowse link 12 40,648,413 40,652,583 RGD:9068941
G WNT10A Wnt family member 10A JBrowse link 2B 224,735,800 224,748,567 RGD:9068941
altered Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G TCF7L2 transcription factor 7 like 2 JBrowse link 10 112,991,588 113,193,992 RGD:9068941
G WNT9A Wnt family member 9A JBrowse link 1 208,299,208 208,306,332 RGD:9068941
the Wnt/calcium signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G WNT11 Wnt family member 11 JBrowse link 11 74,540,025 74,560,024 RGD:9068941
Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G APC APC regulator of WNT signaling pathway JBrowse link 5 113,873,993 114,009,709 RGD:9068941
G AXIN1 axin 1 JBrowse link 16 278,239 337,891 RGD:9068941
G CAV1 caveolin 1 JBrowse link 7 121,193,678 121,229,655 RGD:9068941
G CSNK1G1 casein kinase 1 gamma 1 JBrowse link 15 61,410,414 61,594,180 RGD:9068941
G CTNNB1 catenin beta 1 JBrowse link 3 41,372,368 41,414,030 RGD:9068941
G CUL3 cullin 3 JBrowse link 2B 230,289,195 230,373,537 RGD:9068941
G DVL1 dishevelled segment polarity protein 1 JBrowse link 1 1,292,052 1,300,006 RGD:9068941
G DVL2 dishevelled segment polarity protein 2 JBrowse link 17 7,242,493 7,251,572 RGD:9068941
G DVL3 dishevelled segment polarity protein 3 JBrowse link 3 189,674,405 189,691,749 RGD:9068941
G FZD1 frizzled class receptor 1 JBrowse link 7 96,805,227 96,876,188 RGD:9068941
G FZD10 frizzled class receptor 10 JBrowse link 12 131,989,762 131,992,399 RGD:9068941
G FZD5 frizzled class receptor 5 JBrowse link 2B 213,128,615 213,135,569 RGD:9068941
G GSK3A glycogen synthase kinase 3 alpha JBrowse link 19 47,710,197 47,722,531 RGD:9068941
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 123,856,047 124,126,747 RGD:9068941
G KLHL12 kelch like family member 12 JBrowse link 1 182,785,420 182,821,965 RGD:9068941
G LRP5 LDL receptor related protein 5 JBrowse link 11 66,794,645 66,840,019 RGD:9068941
G LRP6 LDL receptor related protein 6 JBrowse link 12 12,508,108 12,658,074 RGD:9068941
G NKD2 NKD inhibitor of WNT signaling pathway 2 JBrowse link 5 1,075,172 1,081,628 RGD:9068941
G PI4K2A phosphatidylinositol 4-kinase type 2 alpha JBrowse link 10 97,753,860 97,788,054 RGD:9068941
G PIP5K1B phosphatidylinositol-4-phosphate 5-kinase type 1 beta JBrowse link 9 67,469,995 67,774,460 RGD:9068941
G PPP2R5A protein phosphatase 2 regulatory subunit B'alpha JBrowse link 1 192,716,546 192,788,328 RGD:9068941
G RANBP3 RAN binding protein 3 JBrowse link 19 5,865,997 5,927,884 RGD:9068941
G TSC2 TSC complex subunit 2 JBrowse link 16 2,135,696 2,175,569 RGD:9068941
G WNT1 Wnt family member 1 JBrowse link 12 40,648,413 40,652,583 RGD:9068941
G WNT10B Wnt family member 10B JBrowse link 12 40,659,106 40,665,734 RGD:9068941
G WNT3A Wnt family member 3A JBrowse link 1 208,628,706 208,674,469 RGD:9068941
G WNT7A Wnt family member 7A JBrowse link 3 14,075,359 14,138,386 RGD:9068941
G WNT7B Wnt family member 7B JBrowse link 22 44,988,647 45,039,601 RGD:9068941
G WNT9A Wnt family member 9A JBrowse link 1 208,299,208 208,306,332 RGD:9068941
Wnt signaling, non-canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ARRB2 arrestin beta 2 JBrowse link 17 4,757,048 4,767,517 RGD:9068941
G CAMK2A calcium/calmodulin dependent protein kinase II alpha JBrowse link 5 151,649,062 151,719,373 RGD:9068941
G CDC42 cell division cycle 42 JBrowse link 1 22,188,722 22,228,351 RGD:9068941
G CHD7 chromodomain helicase DNA binding protein 7 JBrowse link 8 58,816,836 58,945,186 RGD:9068941
G CSNK1A1 casein kinase 1 alpha 1 JBrowse link 5 150,929,397 150,985,930 RGD:9068941
G CTHRC1 collagen triple helix repeat containing 1 JBrowse link 8 102,182,944 102,194,445 RGD:9068941
G DAAM1 dishevelled associated activator of morphogenesis 1 JBrowse link 14 58,059,616 58,241,353 RGD:9068941
G DVL1 dishevelled segment polarity protein 1 JBrowse link 1 1,292,052 1,300,006 RGD:9068941
G DVL2 dishevelled segment polarity protein 2 JBrowse link 17 7,242,493 7,251,572 RGD:9068941
G DVL3 dishevelled segment polarity protein 3 JBrowse link 3 189,674,405 189,691,749 RGD:9068941
G FLNA filamin A RGD:9068941
G FZD2 frizzled class receptor 2 JBrowse link 17 13,007,752 13,013,346 RGD:9068941
G FZD5 frizzled class receptor 5 JBrowse link 2B 213,128,615 213,135,569 RGD:9068941
G FZD6 frizzled class receptor 6 JBrowse link 8 102,110,317 102,144,363 RGD:9068941
G FZD7 frizzled class receptor 7 JBrowse link 2B 207,444,640 207,448,359 RGD:9068941
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 JBrowse link 6 91,664,263 91,737,468 RGD:9068941
G MAPK10 mitogen-activated protein kinase 10 JBrowse link 4 89,056,754 89,392,980 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 5 182,748,381 182,801,464 RGD:9068941
G NFATC2 nuclear factor of activated T cells 2 JBrowse link 20 48,858,238 49,034,007 RGD:9068941
G NLK nemo like kinase JBrowse link 17 29,088,423 29,238,427 RGD:9068941
G PPARG peroxisome proliferator activated receptor gamma JBrowse link 3 12,560,670 12,705,060 RGD:9068941
G PRKCZ protein kinase C zeta JBrowse link 1 1,918,653 2,046,236 RGD:9068941
G RAC1 Rac family small GTPase 1 JBrowse link 7 6,559,590 6,599,814 RGD:9068941
G RHOA ras homolog family member A JBrowse link 3 50,362,698 50,584,600 RGD:9068941
G ROCK1 Rho associated coiled-coil containing protein kinase 1 JBrowse link 18 17,831,594 17,991,039 RGD:9068941
G ROR2 receptor tyrosine kinase like orphan receptor 2 JBrowse link 9 90,879,826 90,939,834 RGD:9068941
G SETDB1 SET domain bifurcated histone lysine methyltransferase 1 JBrowse link 1 129,925,009 129,962,442 RGD:9068941
G TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 JBrowse link 22 38,122,835 38,158,015 RGD:9068941
G TAB2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 JBrowse link 6 151,868,513 151,936,841 RGD:9068941
G WNT5A Wnt family member 5A JBrowse link 3 56,617,006 56,639,367 RGD:9068941
G WNT7A Wnt family member 7A JBrowse link 3 14,075,359 14,138,386 RGD:9068941
G YES1 YES proto-oncogene 1, Src family tyrosine kinase JBrowse link 18 17,201,973 17,248,074 RGD:9068941
Wnt signaling, the planar cell polarity pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G DVL1 dishevelled segment polarity protein 1 JBrowse link 1 1,292,052 1,300,006 RGD:9068941
G RAC1 Rac family small GTPase 1 JBrowse link 7 6,559,590 6,599,814 RGD:9068941
G RHOA ras homolog family member A JBrowse link 3 50,362,698 50,584,600 RGD:9068941
G WNT7B Wnt family member 7B JBrowse link 22 44,988,647 45,039,601 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 2314
    signaling pathway 1335
      signaling pathway pertinent to development 386
        Wnt signaling pathway 61
          Wnt signaling, canonical pathway + 30
          Wnt signaling, non-canonical pathway + 35
          altered Wnt signaling pathway + 2
Path 2
Term Annotations click to browse term
  pathway 2314
    signaling pathway 1335
      glycoconjugated protein signaling pathway 269
        glycoprotein signaling pathway 149
          Wnt signaling pathway 61
            Wnt signaling, canonical pathway + 30
            Wnt signaling, non-canonical pathway + 35
            altered Wnt signaling pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.