Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:Alzheimer's disease pathway
go back to main search page
Accession:PW:0000015 term browser browse the term
Definition:A mostly sporadic, late-onset condition affecting the central nervous system, that is the most prevalent neurodegenerative disease and the most common form of dementia. It is characterized by the presence of amyloid plaques and fibril tangles. Possible pathways affected range from protein mis-folding and aggregation, to oxidative stress and impaired metal homeostasis.
Synonyms:exact_synonym: Alzheimer disease pathway
 related_synonym: KEGG:05010

View Interactive Diagram


show annotations for term's descendants       view all columns           Sort by:
 
Alzheimer's disease pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2M alpha-2-macroglobulin JBrowse link 12 9,067,708 9,116,229 RGD:1302534
G ADAM10 ADAM metallopeptidase domain 10 JBrowse link 15 58,588,809 58,749,707 RGD:6907045
G ADAM17 ADAM metallopeptidase domain 17 JBrowse link 2 9,488,486 9,555,830 RGD:6907045
G APAF1 apoptotic peptidase activating factor 1 JBrowse link 12 98,645,141 98,735,433 RGD:6907045
G APBB1 amyloid beta precursor protein binding family B member 1 JBrowse link 11 6,395,124 6,419,453 RGD:6907045
G APH1A aph-1 homolog A, gamma-secretase subunit JBrowse link 1 150,265,399 150,282,179 RGD:6907045
G APOE apolipoprotein E JBrowse link 19 44,905,796 44,909,395 RGD:6907045
G APP amyloid beta precursor protein JBrowse link 21 25,880,550 26,171,128 RGD:6907045
G ATF6 activating transcription factor 6 JBrowse link 1 161,766,320 161,964,070 RGD:6907045
G ATP2A1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 JBrowse link 16 28,878,488 28,904,511 RGD:6907045
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 110,281,247 110,351,093 RGD:6907045
G ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 17 3,923,869 3,964,464 RGD:6907045
G ATP5F1A ATP synthase F1 subunit alpha JBrowse link 18 46,080,248 46,104,233 RGD:6907045
G ATP5F1B ATP synthase F1 subunit beta JBrowse link 12 56,638,175 56,645,984 RGD:6907045
G ATP5F1C ATP synthase F1 subunit gamma JBrowse link 10 7,788,104 7,807,801 RGD:6907045
G ATP5F1D ATP synthase F1 subunit delta JBrowse link 19 1,241,751 1,244,825 RGD:6907045
G ATP5F1E ATP synthase F1 subunit epsilon JBrowse link 20 59,025,475 59,032,335 RGD:6907045
G ATP5MC1 ATP synthase membrane subunit c locus 1 JBrowse link 17 48,892,787 48,895,871 RGD:6907045
G ATP5MC2 ATP synthase membrane subunit c locus 2 JBrowse link 12 53,665,160 53,677,546 RGD:6907045
G ATP5MC3 ATP synthase membrane subunit c locus 3 JBrowse link 2 175,176,258 175,181,710 RGD:6907045
G ATP5PB ATP synthase peripheral stalk-membrane subunit b JBrowse link 1 111,449,464 111,462,773 RGD:6907045
G ATP5PD ATP synthase peripheral stalk subunit d JBrowse link 17 75,038,863 75,046,969 RGD:6907045
G ATP5PF ATP synthase peripheral stalk subunit F6 JBrowse link 21 25,724,480 25,735,654 RGD:6907045
G ATP5PO ATP synthase peripheral stalk subunit OSCP JBrowse link 21 33,903,453 33,915,804 RGD:6907045
G BACE1 beta-secretase 1 JBrowse link 11 117,285,207 117,316,256 RGD:6907045
G BACE2 beta-secretase 2 JBrowse link 21 41,168,160 41,282,530 RGD:6907045
G BAD BCL2 associated agonist of cell death JBrowse link 11 64,269,828 64,284,704 RGD:6907045
G BID BH3 interacting domain death agonist JBrowse link 22 17,734,140 17,774,665 RGD:6907045
G CACNA1C calcium voltage-gated channel subunit alpha1 C JBrowse link 12 1,969,552 2,697,950 RGD:6907045
G CACNA1D calcium voltage-gated channel subunit alpha1 D JBrowse link 3 53,494,611 53,813,733 RGD:6907045
G CACNA1F calcium voltage-gated channel subunit alpha1 F JBrowse link X 49,205,063 49,233,404 RGD:6907045
G CACNA1S calcium voltage-gated channel subunit alpha1 S JBrowse link 1 201,039,509 201,112,453 RGD:6907045
G CALM1 calmodulin 1 JBrowse link 14 90,396,502 90,408,275 RGD:6907045
G CALM2 calmodulin 2 JBrowse link 2 47,160,082 47,176,936 RGD:6907045
G CALM3 calmodulin 3 JBrowse link 19 46,601,074 46,610,782 RGD:6907045
G CALML3 calmodulin like 3 JBrowse link 10 5,524,961 5,526,771 RGD:6907045
G CALML5 calmodulin like 5 JBrowse link 10 5,498,697 5,499,570 RGD:6907045
G CALML6 calmodulin like 6 JBrowse link 1 1,913,751 1,917,296 RGD:6907045
G CAPN1 calpain 1 JBrowse link 11 65,181,373 65,212,006 RGD:6907045
G CAPN2 calpain 2 JBrowse link 1 223,701,593 223,776,018 RGD:6907045
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6907045
G CASP7 caspase 7 JBrowse link 10 113,679,162 113,730,909 RGD:6907045
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6907045
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6907045
G CDK5 cyclin dependent kinase 5 JBrowse link 7 151,053,815 151,057,897 RGD:6907045
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 JBrowse link 17 32,485,028 32,491,256 RGD:6907045
G CHP2 calcineurin like EF-hand protein 2 JBrowse link 16 23,755,026 23,758,935 RGD:6907045
G COX4I1 cytochrome c oxidase subunit 4I1 JBrowse link 16 85,799,695 85,807,068 RGD:6907045
G COX4I2 cytochrome c oxidase subunit 4I2 JBrowse link 20 31,637,856 31,645,009 RGD:6907045
G COX5A cytochrome c oxidase subunit 5A JBrowse link 15 74,919,791 74,938,073 RGD:6907045
G COX5B cytochrome c oxidase subunit 5B JBrowse link 2 97,646,062 97,648,383 RGD:6907045
G COX6A1 cytochrome c oxidase subunit 6A1 JBrowse link 12 120,438,113 120,440,730 RGD:6907045
G COX6A2 cytochrome c oxidase subunit 6A2 JBrowse link 16 31,427,731 31,428,360 RGD:6907045
G COX6B1 cytochrome c oxidase subunit 6B1 JBrowse link 19 35,648,323 35,658,782 RGD:6907045
G COX6B2 cytochrome c oxidase subunit 6B2 JBrowse link 19 55,349,704 55,354,719 RGD:6907045
G COX6C cytochrome c oxidase subunit 6C JBrowse link 8 99,877,865 99,893,707 RGD:6907045
G COX7A1 cytochrome c oxidase subunit 7A1 JBrowse link 19 36,150,922 36,152,447 RGD:6907045
G COX7A2 cytochrome c oxidase subunit 7A2 JBrowse link 6 75,237,675 75,250,298 RGD:6907045
G COX7A2L cytochrome c oxidase subunit 7A2 like JBrowse link 2 42,335,559 42,368,957 RGD:6907045
G COX7B cytochrome c oxidase subunit 7B JBrowse link X 77,899,468 77,907,376 RGD:6907045
G COX7B2 cytochrome c oxidase subunit 7B2 JBrowse link 4 46,734,827 46,909,266 RGD:6907045
G COX7C cytochrome c oxidase subunit 7C JBrowse link 5 86,617,941 86,620,962 RGD:6907045
G COX8A cytochrome c oxidase subunit 8A JBrowse link 11 63,974,620 63,976,543 RGD:6907045
G COX8C cytochrome c oxidase subunit 8C JBrowse link 14 93,347,182 93,348,356 RGD:6907045
G CYC1 cytochrome c1 JBrowse link 8 144,095,076 144,097,525 RGD:6907045
G CYCS cytochrome c, somatic JBrowse link 7 25,118,656 25,125,260 RGD:6907045
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 2 88,556,740 88,627,464 RGD:6907045
G ERN1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 17 64,039,142 64,132,469 RGD:6907045
G FADD Fas associated via death domain JBrowse link 11 70,203,296 70,207,390 RGD:6907045
G FAS Fas cell surface death receptor JBrowse link 10 88,968,429 89,017,059 RGD:6907045
G GAPDH glyceraldehyde-3-phosphate dehydrogenase JBrowse link 12 6,534,517 6,538,371 RGD:6907045
G GNAQ G protein subunit alpha q JBrowse link 9 77,716,097 78,031,811 RGD:6907045
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 9 137,139,092 137,168,759 RGD:6907045
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 16 9,753,404 10,182,928 RGD:6907045
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 12 13,537,337 13,982,012 RGD:6907045
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C JBrowse link 17 74,842,021 74,860,843 RGD:6907045
G GRIN2D glutamate ionotropic receptor NMDA type subunit 2D JBrowse link 19 48,394,875 48,444,937 RGD:6907045
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6907045
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 JBrowse link X 53,431,258 53,434,376 RGD:6907045
G IDE insulin degrading enzyme JBrowse link 10 92,451,684 92,574,095 RGD:6907045
G IL1B interleukin 1 beta JBrowse link 2 112,829,751 112,836,843 RGD:6907045
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 JBrowse link 3 4,493,348 4,847,840 RGD:6907045
G ITPR2 inositol 1,4,5-trisphosphate receptor type 2 JBrowse link 12 26,335,352 26,833,197 RGD:6907045
G ITPR3 inositol 1,4,5-trisphosphate receptor type 3 JBrowse link 6 33,621,322 33,696,562 RGD:6907045
G LPL lipoprotein lipase JBrowse link 8 19,939,253 19,967,259 RGD:6907045
G LRP1 LDL receptor related protein 1 JBrowse link 12 57,128,401 57,213,377 RGD:6907045
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6907045
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6907045
G MAPT microtubule associated protein tau JBrowse link 17 45,894,382 46,028,334 RGD:6907045
G MME membrane metalloendopeptidase JBrowse link 3 155,024,124 155,183,729 RGD:6907045
G NAE1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 16 66,802,878 66,830,977 RGD:6907045
G NCSTN nicastrin JBrowse link 1 160,343,328 160,358,949 RGD:6907045
G NDUFA1 NADH:ubiquinone oxidoreductase subunit A1 JBrowse link X 119,871,832 119,876,662 RGD:6907045
G NDUFA10 NADH:ubiquinone oxidoreductase subunit A10 JBrowse link 2 239,892,442 240,025,402 RGD:6907045
G NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 JBrowse link 19 5,891,276 5,903,790 RGD:6907045
G NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 JBrowse link 12 94,971,328 95,003,713 RGD:6907045
G NDUFA13 NADH:ubiquinone oxidoreductase subunit A13 JBrowse link 19 19,516,225 19,528,198 RGD:6907045
G NDUFA2 NADH:ubiquinone oxidoreductase subunit A2 JBrowse link 5 140,645,285 140,647,785 RGD:6907045
G NDUFA3 NADH:ubiquinone oxidoreductase subunit A3 JBrowse link 19 54,102,338 54,107,568 RGD:6907045
G NDUFA4 NDUFA4 mitochondrial complex associated JBrowse link 7 10,931,943 10,940,153 RGD:6907045
G NDUFA4L2 NDUFA4 mitochondrial complex associated like 2 JBrowse link 12 57,234,903 57,240,762 RGD:6907045
G NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 JBrowse link 7 123,536,997 123,601,651 RGD:6907045
G NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 JBrowse link 22 42,085,526 42,090,772 RGD:6907045
G NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 JBrowse link 19 8,308,603 8,321,413 RGD:6907045
G NDUFA8 NADH:ubiquinone oxidoreductase subunit A8 JBrowse link 9 122,132,466 122,159,779 RGD:6907045
G NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 JBrowse link 12 4,649,114 4,694,317 RGD:6907045
G NDUFAB1 NADH:ubiquinone oxidoreductase subunit AB1 JBrowse link 16 23,581,012 23,596,329 RGD:6907045
G NDUFB1 NADH:ubiquinone oxidoreductase subunit B1 JBrowse link 14 92,116,123 92,122,613 RGD:6907045
G NDUFB10 NADH:ubiquinone oxidoreductase subunit B10 JBrowse link 16 1,959,538 1,961,975 RGD:6907045
G NDUFB11 NADH:ubiquinone oxidoreductase subunit B11 JBrowse link X 47,142,216 47,145,210 RGD:6907045
G NDUFB2 NADH:ubiquinone oxidoreductase subunit B2 JBrowse link 7 140,696,708 140,706,643 RGD:6907045
G NDUFB3 NADH:ubiquinone oxidoreductase subunit B3 JBrowse link 2 201,071,784 201,085,750 RGD:6907045
G NDUFB4 NADH:ubiquinone oxidoreductase subunit B4 JBrowse link 3 120,596,336 120,602,507 RGD:6907045
G NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 JBrowse link 3 179,604,787 179,627,647 RGD:6907045
G NDUFB6 NADH:ubiquinone oxidoreductase subunit B6 JBrowse link 9 32,553,001 32,573,184 RGD:6907045
G NDUFB7 NADH:ubiquinone oxidoreductase subunit B7 JBrowse link 19 14,566,078 14,572,066 RGD:6907045
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 JBrowse link 10 100,523,729 100,529,923 RGD:6907045
G NDUFB9 NADH:ubiquinone oxidoreductase subunit B9 JBrowse link 8 124,539,102 124,549,986 RGD:6907045
G NDUFC1 NADH:ubiquinone oxidoreductase subunit C1 JBrowse link 4 139,289,917 139,302,551 RGD:6907045
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 JBrowse link 11 78,068,297 78,079,862 RGD:6907045
G NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 JBrowse link 2 206,114,817 206,159,444 RGD:6907045
G NDUFS2 NADH:ubiquinone oxidoreductase core subunit S2 JBrowse link 1 161,199,315 161,214,395 RGD:6907045
G NDUFS3 NADH:ubiquinone oxidoreductase core subunit S3 JBrowse link 11 47,579,074 47,584,562 RGD:6907045
G NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 JBrowse link 5 53,560,610 53,683,338 RGD:6907045
G NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 JBrowse link 1 39,026,295 39,034,636 RGD:6907045
G NDUFS6 NADH:ubiquinone oxidoreductase subunit S6 JBrowse link 5 1,801,407 1,816,048 RGD:6907045
G NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 JBrowse link 19 1,383,904 1,395,584 RGD:6907045
G NDUFS8 NADH:ubiquinone oxidoreductase core subunit S8 JBrowse link 11 68,030,681 68,036,644 RGD:6907045
G NDUFV1 NADH:ubiquinone oxidoreductase core subunit V1 JBrowse link 11 67,606,936 67,612,554 RGD:6907045
G NDUFV2 NADH:ubiquinone oxidoreductase core subunit V2 JBrowse link 18 9,102,642 9,134,341 RGD:6907045
G NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 JBrowse link 21 42,893,271 42,913,299 RGD:6907045
G NOS1 nitric oxide synthase 1 JBrowse link 12 117,208,142 117,361,802 RGD:6907045
G PLCB1 phospholipase C beta 1 JBrowse link 20 8,132,266 8,884,900 RGD:6907045
G PLCB2 phospholipase C beta 2 JBrowse link 15 40,285,496 40,307,945 RGD:6907045
G PLCB3 phospholipase C beta 3 JBrowse link 11 64,251,530 64,269,452 RGD:6907045
G PLCB4 phospholipase C beta 4 JBrowse link 20 9,068,710 9,480,816 RGD:6907045
G PPP3CA protein phosphatase 3 catalytic subunit alpha JBrowse link 4 101,023,418 101,348,295 RGD:6907045
G PPP3CB protein phosphatase 3 catalytic subunit beta JBrowse link 10 73,436,428 73,496,024 RGD:6907045
G PPP3CC protein phosphatase 3 catalytic subunit gamma JBrowse link 8 22,440,970 22,541,466 RGD:6907045
G PPP3R1 protein phosphatase 3 regulatory subunit B, alpha JBrowse link 2 68,178,857 68,252,532 RGD:6907045
G PPP3R2 protein phosphatase 3 regulatory subunit B, beta JBrowse link 9 101,591,604 101,594,969 RGD:6907045
G PSEN1 presenilin 1 JBrowse link 14 73,136,436 73,223,691 RGD:6907045
G PSEN2 presenilin 2 JBrowse link 1 226,870,572 226,903,829 RGD:6907045
RGD:9743900
G PSENEN presenilin enhancer, gamma-secretase subunit JBrowse link 19 35,745,651 35,747,519 RGD:6907045
G RYR3 ryanodine receptor 3 JBrowse link 15 33,310,773 33,866,121 RGD:6907045
G SDHA succinate dehydrogenase complex flavoprotein subunit A JBrowse link 5 218,223 264,816 RGD:6907045
G SDHB succinate dehydrogenase complex iron sulfur subunit B JBrowse link 1 17,018,722 17,054,032 RGD:6907045
G SDHC succinate dehydrogenase complex subunit C JBrowse link 1 161,314,381 161,375,340 RGD:6907045
G SDHD succinate dehydrogenase complex subunit D JBrowse link 11 112,086,873 112,095,794 RGD:6907045
G SNCA synuclein alpha JBrowse link 4 89,724,099 89,838,324 RGD:6907045
RGD:1302528
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:6907045
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 12 6,328,771 6,342,076 RGD:6907045
G UBE2D2 ubiquitin conjugating enzyme E2 D2 JBrowse link 5 139,561,166 139,628,434 RGD:1302873
G UBE2I ubiquitin conjugating enzyme E2 I JBrowse link 16 1,309,152 1,327,017 RGD:1302873
G UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X JBrowse link 22 29,767,369 29,770,413 RGD:6907045
G UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI JBrowse link 19 1,597,169 1,605,462 RGD:6907045
G UQCRB ubiquinol-cytochrome c reductase binding protein JBrowse link 8 96,222,947 96,235,545 RGD:6907045
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 JBrowse link 3 48,599,002 48,609,664 RGD:6907045
G UQCRC2 ubiquinol-cytochrome c reductase core protein 2 JBrowse link 16 21,953,361 21,983,660 RGD:6907045
G UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 JBrowse link 19 29,205,320 29,213,151 RGD:6907045
G UQCRH ubiquinol-cytochrome c reductase hinge protein JBrowse link 1 46,303,698 46,316,776 RGD:6907045
G UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII JBrowse link 5 132,866,642 132,868,847 RGD:6907045

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5944
    disease pathway 2071
      nervous system disease pathway 765
        neurodegenerative pathway 366
          Alzheimer's disease pathway 162
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.