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Term:amyotrophic lateral sclerosis pathway
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Accession:PW:0000016 term browser browse the term
Definition:A late onset, mostly sporadic neurodegenerative disease characterized by the loss of motor neurons in the brain stem and spinal cord. Various pathways are thought to be deregulated and contribute to the condition; among them calcium and/or zinc homeostasis, apoptosis, Cdk5 and calcineurin dependent processes, and in the case of the more rare, genetically inherited form of the disease, mutations in the cytosolic Cu, Zn superoxide dismutase (SOD1) and the subsequent changes in the processes that involve SOD1.
Synonyms:exact_synonym: ALS pathway;   amyotrophic lateral sclerosis disease pathway
 related_synonym: KEGG:05014

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amyotrophic lateral sclerosis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link NW_004955403 22,449 104,577 RGD:9068941
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link NW_004955405 34,619,780 34,693,616 RGD:9068941
G Bad BCL2 associated agonist of cell death JBrowse link NW_004955422 20,795,585 20,809,039 RGD:9068941
G Bax BCL2 associated X, apoptosis regulator JBrowse link NW_004955559 1,695,960 1,700,246 RGD:9068941
G Bcl2 BCL2 apoptosis regulator JBrowse link NW_004955402 46,911,125 47,084,214 RGD:9068941
G Bcl2l1 BCL2 like 1 JBrowse link NW_004955422 29,254,440 29,307,104 RGD:9068941
G Bid BH3 interacting domain death agonist JBrowse link NW_004955454 5,776,656 5,785,500 RGD:9068941
G Casp3 caspase 3 JBrowse link NW_004955403 24,315,712 24,326,271 RGD:9068941
G Casp9 caspase 9 JBrowse link NW_004955527 2,613,691 2,630,217 RGD:9068941
G Cat catalase JBrowse link NW_004955422 11,783,973 11,826,970 RGD:9068941
G Ccs copper chaperone for superoxide dismutase JBrowse link NW_004955422 18,761,703 18,772,762 RGD:9068941
G Chp2 calcineurin like EF-hand protein 2 JBrowse link NW_004955493 2,278,494 2,281,125 RGD:9068941
G Daxx death domain associated protein JBrowse link NW_004955437 1,869,692 1,874,041 RGD:9068941
G Derl1 derlin 1 JBrowse link NW_004955540 1,918,230 1,944,186 RGD:9068941
G Gpx1 glutathione peroxidase 1 JBrowse link NW_004955532 1,298,336 1,298,830 RGD:9068941
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link NW_004955408 7,912,223 8,226,241 RGD:9068941
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link NW_004955471 9,970,396 10,108,871 RGD:9068941
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link NW_004955513 5,154,864 5,178,636 RGD:9068941
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link NW_004955442 8,171,114 8,565,187 RGD:9068941
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link NW_004955413 10,358,931 10,780,004 RGD:9068941
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C JBrowse link NW_004955553 1,729,431 1,746,754 RGD:9068941
G Grin2d glutamate ionotropic receptor NMDA type subunit 2D JBrowse link NW_004955559 2,042,723 2,080,706 RGD:9068941
G LOC102023786 cytochrome c, somatic JBrowse link NW_004955410 27,086,405 27,089,255 RGD:9068941
G Map2k3 mitogen-activated protein kinase kinase 3 JBrowse link NW_004955577 1,225,033 1,249,510 RGD:9068941
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link NW_004955478 3,331,607 3,448,840 RGD:9068941
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link NW_004955439 162,499 376,919 RGD:9068941
G Mapk11 mitogen-activated protein kinase 11 JBrowse link NW_004955413 33,287,860 33,293,948 RGD:9068941
G Mapk12 mitogen-activated protein kinase 12 JBrowse link NW_004955413 33,278,913 33,285,920 RGD:9068941
G Mapk13 mitogen-activated protein kinase 13 JBrowse link NW_004955437 3,899,988 3,907,781 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004955437 3,836,331 3,884,083 RGD:9068941
G Nefh neurofilament heavy JBrowse link NW_004955455 3,735,330 3,744,714 RGD:9068941
G Nefl neurofilament light JBrowse link NW_004955403 47,946,413 47,951,734 RGD:9068941
G Nefm neurofilament medium JBrowse link NW_004955403 47,920,408 47,926,922 RGD:9068941
G Nos1 nitric oxide synthase 1 JBrowse link NW_004955455 13,797,557 13,978,402 RGD:9068941
G Ppp3ca protein phosphatase 3 catalytic subunit alpha JBrowse link NW_004955496 6,934,542 7,059,745 RGD:9068941
G Ppp3cb protein phosphatase 3 catalytic subunit beta JBrowse link NW_004955437 18,323,852 18,377,815 RGD:9068941
G Ppp3cc protein phosphatase 3 catalytic subunit gamma JBrowse link NW_004955403 45,915,985 45,969,350 RGD:9068941
G Ppp3r1 protein phosphatase 3 regulatory subunit B, alpha JBrowse link NW_004955424 16,624,214 16,690,783 RGD:9068941
G Ppp3r2 protein phosphatase 3 regulatory subunit B, beta JBrowse link NW_004955419 24,252,772 24,253,730 RGD:9068941
G Prph peripherin JBrowse link NW_004955500 8,106,371 8,117,221 RGD:9068941
G Prph2 peripherin 2 JBrowse link NW_004955437 8,784,211 8,794,789 RGD:9068941
G Rab5a RAB5A, member RAS oncogene family JBrowse link NW_004955430 11,991,548 12,040,003 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Slc1a2 solute carrier family 1 member 2 JBrowse link NW_004955422 10,929,987 11,082,220 RGD:9068941
G Sod1 superoxide dismutase 1 JBrowse link NW_004955407 31,261,451 31,267,657 RGD:9068941
G Tnf tumor necrosis factor JBrowse link NW_004955437 117,267 119,899 RGD:9068941
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link NW_004955413 3,982,670 3,996,320 RGD:9068941
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link NW_004955486 1,790,531 1,817,986 RGD:9068941
G Tomm40 translocase of outer mitochondrial membrane 40 JBrowse link NW_004955555 1,987,063 1,997,329 RGD:9068941
G Tomm40l translocase of outer mitochondrial membrane 40 like JBrowse link NW_004955468 12,981,023 12,984,999 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004955467 9,241,391 9,256,716 RGD:9068941

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Path 1
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  pathway 5435
    disease pathway 1797
      nervous system disease pathway 712
        neurodegenerative pathway 330
          amyotrophic lateral sclerosis pathway 51
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.