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ONTOLOGY REPORT - ANNOTATIONS


Term:glycolysis/gluconeogenesis pathway
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Accession:PW:0000025 term browser browse the term
Definition:Those metabolic reactions involved in the energy-yielding conversion of glucose to pyruvate or in the formation of glucose from non-carbohydrate precursors such as pyruvate, lactate, citric acid cycle intermediates, the carbon skeleton of many amino acids. While many enzymes are shared by the two pathways, a few steps are carried out by pathway-specific enzymes. The two pathways are independently regulated.
Synonyms:related_synonym: KEGG:00010


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glycolysis/gluconeogenesis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACSS1 acyl-CoA synthetase short chain family member 1 JBrowse link 17 30,800,536 30,839,799 RGD:9068941
G ACSS2 acyl-CoA synthetase short chain family member 2 JBrowse link 17 38,260,152 38,315,764 RGD:9068941
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 8
X
121,225,485
98,582,002
121,259,262
98,583,002
RGD:9068941
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 8 121,266,794 121,282,313 RGD:9068941
G ADPGK ADP dependent glucokinase JBrowse link 7 60,584,038 60,623,898 RGD:9068941
G AKR1A1 aldo-keto reductase family 1 member A1 JBrowse link 6 165,811,245 165,825,168 RGD:9068941
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 JBrowse link 1 139,451,080 139,491,514 RGD:9068941
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 JBrowse link 1 239,109,814 239,114,736 RGD:9068941
G ALDH2 aldehyde dehydrogenase 2 family member JBrowse link 14 39,902,317 39,933,113 RGD:9068941
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 JBrowse link 12 59,895,476 59,905,900 RGD:9068941
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 JBrowse link 12 59,936,838 59,953,677 RGD:9068941
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 JBrowse link 2 4,868,561 4,889,179 RGD:9068941
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 JBrowse link 2 129,663,226 129,709,728 RGD:9068941
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 JBrowse link 4 85,029,914 85,057,650 RGD:9068941
G ALDOA aldolase, fructose-bisphosphate A JBrowse link 3 18,246,036 18,260,167 RGD:9068941
G ALDOB aldolase, fructose-bisphosphate B JBrowse link 1 243,127,870 243,141,504 RGD:9068941
G ALDOC aldolase, fructose-bisphosphate C JBrowse link 12 44,823,376 44,827,273 RGD:9068941
G BPGM bisphosphoglycerate mutase JBrowse link 18 14,555,919 14,593,321 RGD:9068941
G DLAT dihydrolipoamide S-acetyltransferase JBrowse link 9 39,738,639 39,763,813 RGD:9068941
G DLD dihydrolipoamide dehydrogenase JBrowse link 9 107,642,129 107,668,443 RGD:9068941
G ENO1 enolase 1 JBrowse link 6 69,385,879 69,401,664 RGD:9068941
G ENO2 enolase 2 JBrowse link 5 63,799,927 63,809,067 RGD:9068941
G ENO3 enolase 3 JBrowse link 12 51,954,614 51,959,991 RGD:9068941
G FBP1 fructose-bisphosphatase 1 JBrowse link 10 27,588,609 27,622,225 RGD:9068941
G FBP2 fructose-bisphosphatase 2 JBrowse link 10 27,631,833 27,661,704 RGD:9068941
G G6PC glucose-6-phosphatase catalytic subunit JBrowse link 12 19,965,885 19,975,783 RGD:9068941
G G6PC2 glucose-6-phosphatase catalytic subunit 2 JBrowse link 15 75,382,442 75,388,662 RGD:9068941
G GALM galactose mutarotase JBrowse link 3 101,617,521 101,682,821 RGD:9068941
G GAPDH glyceraldehyde-3-phosphate dehydrogenase JBrowse link 5 64,129,678 64,135,194 RGD:9068941
G GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic JBrowse link 6 44,968,965 44,978,992 RGD:9068941
G GCK glucokinase JBrowse link 18 50,979,167 51,024,500 RGD:9068941
G GPI glucose-6-phosphate isomerase JBrowse link 6 44,038,374 44,069,331 RGD:9068941
G HK1 hexokinase 1 JBrowse link 14 72,383,328 72,460,927 RGD:9068941
G HK2 hexokinase 2 JBrowse link 3 68,155,656 68,231,187 RGD:9068941
G HK3 hexokinase 3 JBrowse link 2 81,042,401 81,060,832 RGD:9068941
G HKDC1 hexokinase domain containing 1 JBrowse link 14 72,285,941 72,343,990 RGD:9068941
G LDHA lactate dehydrogenase A JBrowse link 2 40,814,163 40,827,284 RGD:9068941
G LDHB lactate dehydrogenase B JBrowse link 5 51,810,932 51,831,218 RGD:9068941
G LDHC lactate dehydrogenase C JBrowse link 2 40,748,567 40,810,114 RGD:9068941
G LOC100522421 aldehyde dehydrogenase family 3 member B2-like JBrowse link 2 4,910,123 4,928,559 RGD:9068941
G LOC110261964 alcohol dehydrogenase 6-like JBrowse link 8 121,170,548 121,181,415 RGD:9068941
G MLXIPL MLX interacting protein like JBrowse link 3 10,898,675 10,934,257 RGD:9068941
G PCK1 phosphoenolpyruvate carboxykinase 1 JBrowse link 17 57,930,507 57,936,523 RGD:9068941
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial JBrowse link 7 75,187,195 75,197,613 RGD:9068941
G PDHA1 pyruvate dehydrogenase E1 alpha 1 subunit JBrowse link X 15,699,924 15,718,908 RGD:9068941
G PDHA2 pyruvate dehydrogenase E1 alpha 2 subunit JBrowse link 8 123,926,253 123,927,419 RGD:9068941
G PDHB pyruvate dehydrogenase E1 beta subunit JBrowse link 13 40,161,519 40,167,502 RGD:9068941
G PFKL phosphofructokinase, liver type JBrowse link 13 207,167,287 207,191,688 RGD:9068941
G PFKM phosphofructokinase, muscle JBrowse link 5 78,475,473 78,525,052 RGD:9068941
G PFKP phosphofructokinase, platelet JBrowse link 10 67,022,652 67,082,336 RGD:9068941
G PGAM1 phosphoglycerate mutase 1 JBrowse link 14 108,822,782 108,832,818 RGD:9068941
G PGAM2 phosphoglycerate mutase 2 JBrowse link 18 48,693,832 48,712,787 RGD:9068941
G PGK1 phosphoglycerate kinase 1 JBrowse link X 62,187,472 62,210,321 RGD:9068941
G PGK2 phosphoglycerate kinase 2 JBrowse link 7 43,839,239 43,840,892 RGD:9068941
G PGM1 phosphoglucomutase 1 JBrowse link 6 148,851,183 148,918,891 RGD:9068941
G PGM2 phosphoglucomutase 2 JBrowse link 8 29,307,628 29,343,012 RGD:9068941
G PKLR pyruvate kinase L/R JBrowse link 4 94,536,978 94,546,561 RGD:9068941
G TPI1 triosephosphate isomerase 1 JBrowse link 5 63,839,473 63,842,853 RGD:9068941
gluconeogenesis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACSS1 acyl-CoA synthetase short chain family member 1 JBrowse link 17 30,800,536 30,839,799 RGD:9068941
G ACSS2 acyl-CoA synthetase short chain family member 2 JBrowse link 17 38,260,152 38,315,764 RGD:9068941
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 8
X
121,225,485
98,582,002
121,259,262
98,583,002
RGD:9068941
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 8 121,266,794 121,282,313 RGD:9068941
G ADPGK ADP dependent glucokinase JBrowse link 7 60,584,038 60,623,898 RGD:9068941
G AKR1A1 aldo-keto reductase family 1 member A1 JBrowse link 6 165,811,245 165,825,168 RGD:9068941
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 JBrowse link 1 139,451,080 139,491,514 RGD:9068941
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 JBrowse link 1 239,109,814 239,114,736 RGD:9068941
G ALDH2 aldehyde dehydrogenase 2 family member JBrowse link 14 39,902,317 39,933,113 RGD:9068941
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 JBrowse link 12 59,895,476 59,905,900 RGD:9068941
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 JBrowse link 12 59,936,838 59,953,677 RGD:9068941
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 JBrowse link 2 4,868,561 4,889,179 RGD:9068941
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 JBrowse link 2 129,663,226 129,709,728 RGD:9068941
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 JBrowse link 4 85,029,914 85,057,650 RGD:9068941
G ALDOA aldolase, fructose-bisphosphate A JBrowse link 3 18,246,036 18,260,167 RGD:9068941
G ALDOB aldolase, fructose-bisphosphate B JBrowse link 1 243,127,870 243,141,504 RGD:9068941
G ALDOC aldolase, fructose-bisphosphate C JBrowse link 12 44,823,376 44,827,273 RGD:9068941
G BPGM bisphosphoglycerate mutase JBrowse link 18 14,555,919 14,593,321 RGD:9068941
G DLAT dihydrolipoamide S-acetyltransferase JBrowse link 9 39,738,639 39,763,813 RGD:9068941
G DLD dihydrolipoamide dehydrogenase JBrowse link 9 107,642,129 107,668,443 RGD:9068941
G ENO1 enolase 1 JBrowse link 6 69,385,879 69,401,664 RGD:9068941
G ENO2 enolase 2 JBrowse link 5 63,799,927 63,809,067 RGD:9068941
G ENO3 enolase 3 JBrowse link 12 51,954,614 51,959,991 RGD:9068941
G FBP1 fructose-bisphosphatase 1 JBrowse link 10 27,588,609 27,622,225 RGD:9068941
G FBP2 fructose-bisphosphatase 2 JBrowse link 10 27,631,833 27,661,704 RGD:9068941
G G6PC glucose-6-phosphatase catalytic subunit JBrowse link 12 19,965,885 19,975,783 RGD:9068941
G G6PC2 glucose-6-phosphatase catalytic subunit 2 JBrowse link 15 75,382,442 75,388,662 RGD:9068941
G G6PC3 glucose-6-phosphatase catalytic subunit 3 JBrowse link 12 19,121,540 19,126,291 RGD:9068941
G GALM galactose mutarotase JBrowse link 3 101,617,521 101,682,821 RGD:9068941
G GAPDH glyceraldehyde-3-phosphate dehydrogenase JBrowse link 5 64,129,678 64,135,194 RGD:9068941
G GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic JBrowse link 6 44,968,965 44,978,992 RGD:9068941
G GCK glucokinase JBrowse link 18 50,979,167 51,024,500 RGD:9068941
G GOT1 glutamic-oxaloacetic transaminase 1 JBrowse link 14 110,608,422 110,635,825 RGD:9068941
G GOT2 glutamic-oxaloacetic transaminase 2 JBrowse link 6 20,407,203 20,431,849 RGD:9068941
G GPI glucose-6-phosphate isomerase JBrowse link 6 44,038,374 44,069,331 RGD:9068941
G HK1 hexokinase 1 JBrowse link 14 72,383,328 72,460,927 RGD:9068941
G HK2 hexokinase 2 JBrowse link 3 68,155,656 68,231,187 RGD:9068941
G HK3 hexokinase 3 JBrowse link 2 81,042,401 81,060,832 RGD:9068941
G HKDC1 hexokinase domain containing 1 JBrowse link 14 72,285,941 72,343,990 RGD:9068941
G LDHA lactate dehydrogenase A JBrowse link 2 40,814,163 40,827,284 RGD:9068941
G LDHB lactate dehydrogenase B JBrowse link 5 51,810,932 51,831,218 RGD:9068941
G LDHC lactate dehydrogenase C JBrowse link 2 40,748,567 40,810,114 RGD:9068941
G LOC100522421 aldehyde dehydrogenase family 3 member B2-like JBrowse link 2 4,910,123 4,928,559 RGD:9068941
G LOC110261964 alcohol dehydrogenase 6-like JBrowse link 8 121,170,548 121,181,415 RGD:9068941
G MDH2 malate dehydrogenase 2 JBrowse link 3 10,120,121 10,132,705 RGD:9068941
G MPC1 mitochondrial pyruvate carrier 1 JBrowse link 1 2,541,475 2,552,864 RGD:9068941
G PANK1 pantothenate kinase 1 JBrowse link 14 101,410,139 101,512,498 RGD:9068941
G PC pyruvate carboxylase JBrowse link 2 5,566,608 5,587,797 RGD:9068941
G PCK1 phosphoenolpyruvate carboxykinase 1 JBrowse link 17 57,930,507 57,936,523 RGD:9068941
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial JBrowse link 7 75,187,195 75,197,613 RGD:9068941
G PDHA1 pyruvate dehydrogenase E1 alpha 1 subunit JBrowse link X 15,699,924 15,718,908 RGD:9068941
G PDHA2 pyruvate dehydrogenase E1 alpha 2 subunit JBrowse link 8 123,926,253 123,927,419 RGD:9068941
G PDHB pyruvate dehydrogenase E1 beta subunit JBrowse link 13 40,161,519 40,167,502 RGD:9068941
G PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 JBrowse link X 47,771,751 47,859,079 RGD:9068941
G PFKL phosphofructokinase, liver type JBrowse link 13 207,167,287 207,191,688 RGD:9068941
G PFKM phosphofructokinase, muscle JBrowse link 5 78,475,473 78,525,052 RGD:9068941
G PFKP phosphofructokinase, platelet JBrowse link 10 67,022,652 67,082,336 RGD:9068941
G PGAM1 phosphoglycerate mutase 1 JBrowse link 14 108,822,782 108,832,818 RGD:9068941
G PGAM2 phosphoglycerate mutase 2 JBrowse link 18 48,693,832 48,712,787 RGD:9068941
G PGK1 phosphoglycerate kinase 1 JBrowse link X 62,187,472 62,210,321 RGD:9068941
G PGK2 phosphoglycerate kinase 2 JBrowse link 7 43,839,239 43,840,892 RGD:9068941
G PGM1 phosphoglucomutase 1 JBrowse link 6 148,851,183 148,918,891 RGD:9068941
G PGM2 phosphoglucomutase 2 JBrowse link 8 29,307,628 29,343,012 RGD:9068941
G PKLR pyruvate kinase L/R JBrowse link 4 94,536,978 94,546,561 RGD:9068941
G SLC25A11 solute carrier family 25 member 11 JBrowse link 12 51,970,794 51,973,668 RGD:9068941
G SLC2A2 solute carrier family 2 member 2 JBrowse link 13 109,592,595 109,614,105 RGD:9068941
G SLC37A4 solute carrier family 37 member 4 JBrowse link 9 46,247,278 46,254,068 RGD:9068941
G TPI1 triosephosphate isomerase 1 JBrowse link 5 63,839,473 63,842,853 RGD:9068941
glycolysis pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACSS1 acyl-CoA synthetase short chain family member 1 JBrowse link 17 30,800,536 30,839,799 RGD:9068941
G ACSS2 acyl-CoA synthetase short chain family member 2 JBrowse link 17 38,260,152 38,315,764 RGD:9068941
G ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 8
X
121,225,485
98,582,002
121,259,262
98,583,002
RGD:9068941
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide JBrowse link 8 121,266,794 121,282,313 RGD:9068941
G ADPGK ADP dependent glucokinase JBrowse link 7 60,584,038 60,623,898 RGD:9068941
G AKR1A1 aldo-keto reductase family 1 member A1 JBrowse link 6 165,811,245 165,825,168 RGD:9068941
G ALDH1A3 aldehyde dehydrogenase 1 family member A3 JBrowse link 1 139,451,080 139,491,514 RGD:9068941
G ALDH1B1 aldehyde dehydrogenase 1 family member B1 JBrowse link 1 239,109,814 239,114,736 RGD:9068941
G ALDH2 aldehyde dehydrogenase 2 family member JBrowse link 14 39,902,317 39,933,113 RGD:9068941
G ALDH3A1 aldehyde dehydrogenase 3 family member A1 JBrowse link 12 59,895,476 59,905,900 RGD:9068941
G ALDH3A2 aldehyde dehydrogenase 3 family member A2 JBrowse link 12 59,936,838 59,953,677 RGD:9068941
G ALDH3B1 aldehyde dehydrogenase 3 family member B1 JBrowse link 2 4,868,561 4,889,179 RGD:9068941
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 JBrowse link 2 129,663,226 129,709,728 RGD:9068941
G ALDH9A1 aldehyde dehydrogenase 9 family member A1 JBrowse link 4 85,029,914 85,057,650 RGD:9068941
G ALDOA aldolase, fructose-bisphosphate A JBrowse link 3 18,246,036 18,260,167 RGD:9068941
G ALDOB aldolase, fructose-bisphosphate B JBrowse link 1 243,127,870 243,141,504 RGD:9068941
G ALDOC aldolase, fructose-bisphosphate C JBrowse link 12 44,823,376 44,827,273 RGD:9068941
G BPGM bisphosphoglycerate mutase JBrowse link 18 14,555,919 14,593,321 RGD:9068941
G DLAT dihydrolipoamide S-acetyltransferase JBrowse link 9 39,738,639 39,763,813 RGD:9068941
G DLD dihydrolipoamide dehydrogenase JBrowse link 9 107,642,129 107,668,443 RGD:9068941
G ENO1 enolase 1 JBrowse link 6 69,385,879 69,401,664 RGD:9068941
G ENO2 enolase 2 JBrowse link 5 63,799,927 63,809,067 RGD:9068941
G ENO3 enolase 3 JBrowse link 12 51,954,614 51,959,991 RGD:9068941
G FBP1 fructose-bisphosphatase 1 JBrowse link 10 27,588,609 27,622,225 RGD:9068941
G FBP2 fructose-bisphosphatase 2 JBrowse link 10 27,631,833 27,661,704 RGD:9068941
G G6PC glucose-6-phosphatase catalytic subunit JBrowse link 12 19,965,885 19,975,783 RGD:9068941
G G6PC2 glucose-6-phosphatase catalytic subunit 2 JBrowse link 15 75,382,442 75,388,662 RGD:9068941
G GALM galactose mutarotase JBrowse link 3 101,617,521 101,682,821 RGD:9068941
G GAPDH glyceraldehyde-3-phosphate dehydrogenase JBrowse link 5 64,129,678 64,135,194 RGD:9068941
G GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic JBrowse link 6 44,968,965 44,978,992 RGD:9068941
G GCK glucokinase JBrowse link 18 50,979,167 51,024,500 RGD:9068941
G GPI glucose-6-phosphate isomerase JBrowse link 6 44,038,374 44,069,331 RGD:9068941
G HK1 hexokinase 1 JBrowse link 14 72,383,328 72,460,927 RGD:9068941
G HK2 hexokinase 2 JBrowse link 3 68,155,656 68,231,187 RGD:9068941
G HK3 hexokinase 3 JBrowse link 2 81,042,401 81,060,832 RGD:9068941
G HKDC1 hexokinase domain containing 1 JBrowse link 14 72,285,941 72,343,990 RGD:9068941
G LDHA lactate dehydrogenase A JBrowse link 2 40,814,163 40,827,284 RGD:9068941
G LDHB lactate dehydrogenase B JBrowse link 5 51,810,932 51,831,218 RGD:9068941
G LDHC lactate dehydrogenase C JBrowse link 2 40,748,567 40,810,114 RGD:9068941
G LOC100522421 aldehyde dehydrogenase family 3 member B2-like JBrowse link 2 4,910,123 4,928,559 RGD:9068941
G LOC110261964 alcohol dehydrogenase 6-like JBrowse link 8 121,170,548 121,181,415 RGD:9068941
G PANK1 pantothenate kinase 1 JBrowse link 14 101,410,139 101,512,498 RGD:9068941
G PCK1 phosphoenolpyruvate carboxykinase 1 JBrowse link 17 57,930,507 57,936,523 RGD:9068941
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial JBrowse link 7 75,187,195 75,197,613 RGD:9068941
G PDHA1 pyruvate dehydrogenase E1 alpha 1 subunit JBrowse link X 15,699,924 15,718,908 RGD:9068941
G PDHA2 pyruvate dehydrogenase E1 alpha 2 subunit JBrowse link 8 123,926,253 123,927,419 RGD:9068941
G PDHB pyruvate dehydrogenase E1 beta subunit JBrowse link 13 40,161,519 40,167,502 RGD:9068941
G PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 JBrowse link X 47,771,751 47,859,079 RGD:9068941
G PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 JBrowse link 9 67,681,786 67,716,921 RGD:9068941
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 JBrowse link 10 64,776,315 64,859,118 RGD:9068941
G PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 JBrowse link 13 31,212,553 31,259,785 RGD:9068941
G PFKL phosphofructokinase, liver type JBrowse link 13 207,167,287 207,191,688 RGD:9068941
G PFKM phosphofructokinase, muscle JBrowse link 5 78,475,473 78,525,052 RGD:9068941
G PFKP phosphofructokinase, platelet JBrowse link 10 67,022,652 67,082,336 RGD:9068941
G PGAM1 phosphoglycerate mutase 1 JBrowse link 14 108,822,782 108,832,818 RGD:9068941
G PGAM2 phosphoglycerate mutase 2 JBrowse link 18 48,693,832 48,712,787 RGD:9068941
G PGK1 phosphoglycerate kinase 1 JBrowse link X 62,187,472 62,210,321 RGD:9068941
G PGK2 phosphoglycerate kinase 2 JBrowse link 7 43,839,239 43,840,892 RGD:9068941
G PGM1 phosphoglucomutase 1 JBrowse link 6 148,851,183 148,918,891 RGD:9068941
G PGM2 phosphoglucomutase 2 JBrowse link 8 29,307,628 29,343,012 RGD:9068941
G PKLR pyruvate kinase L/R JBrowse link 4 94,536,978 94,546,561 RGD:9068941
G PKM pyruvate kinase, muscle JBrowse link 7 60,971,807 61,032,780 RGD:9068941
G SLC2A2 solute carrier family 2 member 2 JBrowse link 13 109,592,595 109,614,105 RGD:9068941
G TPI1 triosephosphate isomerase 1 JBrowse link 5 63,839,473 63,842,853 RGD:9068941

Term paths to the root
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  pathway 5631
    classic metabolic pathway 1711
      carbohydrate metabolic pathway 509
        glycolysis/gluconeogenesis pathway 73
          gluconeogenesis pathway 68
          glycolysis pathway 64
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.