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ONTOLOGY REPORT - ANNOTATIONS


Term:long term depression
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Accession:PW:0000061 term browser browse the term
Definition:Long term depression is a weakening of a synapse that lasts hours to days. It results from either strong synaptic stimulation (as in the cerebellum) or to weak synaptic stimulation (as in the hippocampus), and engages several cascades.
Comment:Adapted from Wikipedia at OneLook
Synonyms:related_synonym: KEGG:04730;   LTD


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long term depression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:6907045
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6907045
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:6907045
G Crhr1 corticotropin releasing hormone receptor 1 JBrowse link 10 92,191,473 92,233,662 RGD:6907045
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1600981
G Drd5 dopamine receptor D5 JBrowse link 14 77,220,579 77,222,006 RGD:1600981
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:6907045
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:6907045
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:6907045
G Gnai1 G protein subunit alpha i1 JBrowse link 4 13,405,136 13,486,866 RGD:6907045
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:6907045
G Gnai3 G protein subunit alpha i3 JBrowse link 2 210,896,779 210,934,733 RGD:6907045
G Gnao1 G protein subunit alpha o1 JBrowse link 19 11,513,201 11,669,578 RGD:6907045
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6907045
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:6907045
G Gnaz G protein subunit alpha z JBrowse link 20 14,593,072 14,644,020 RGD:6907045
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 JBrowse link 10 42,441,723 42,760,200 RGD:6907045
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:6907045
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 JBrowse link X 127,561,843 127,829,763 RGD:6907045
G Grid2 glutamate ionotropic receptor delta type subunit 2 JBrowse link 4 94,068,112 95,476,864 RGD:6907045
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A JBrowse link 10 5,707,806 6,123,568 RGD:1642204
RGD:1642207
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:6907045
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:6907045
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1641844
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 JBrowse link 2 181,045,694 181,103,321 RGD:6907045
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 JBrowse link 8 408,001 899,851 RGD:6907045
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 JBrowse link 2 180,976,939 181,026,001 RGD:6907045
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 JBrowse link 15 45,479,662 45,550,285 RGD:6907045
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:6907045
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6907045
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:6907045
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 JBrowse link 4 140,247,297 140,580,749 RGD:6907045
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 JBrowse link 4 180,423,452 180,800,088 RGD:6907045
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 JBrowse link 20 5,645,894 5,711,702 RGD:6907045
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:6907045
G Lyn LYN proto-oncogene, Src family tyrosine kinase JBrowse link 5 16,526,058 16,642,648 RGD:6907045
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:6907045
G Map2k2 mitogen activated protein kinase kinase 2 JBrowse link 7 11,458,971 11,478,520 RGD:6907045
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6907045
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6907045
G Nos1 nitric oxide synthase 1 JBrowse link 12 44,214,949 44,405,530 RGD:6907045
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:6907045
G Pla2g10 phospholipase A2, group X JBrowse link 10 1,509,732 1,520,970 RGD:6907045
G Pla2g12a phospholipase A2, group XIIA JBrowse link 2 235,311,664 235,327,972 RGD:6907045
G Pla2g12b phospholipase A2, group XIIB JBrowse link 20 28,989,440 29,007,967 RGD:6907045
G Pla2g1b phospholipase A2 group IB JBrowse link 12 46,879,346 46,890,234 RGD:6907045
G Pla2g2a phospholipase A2 group IIA JBrowse link 5 157,282,650 157,285,295 RGD:6907045
G Pla2g2c phospholipase A2, group IIC JBrowse link 5 157,163,672 157,187,654 RGD:6907045
G Pla2g2d phospholipase A2, group IID JBrowse link 5 157,222,636 157,228,795 RGD:6907045
G Pla2g2f phospholipase A2, group IIF JBrowse link 5 157,192,047 157,217,265 RGD:6907045
G Pla2g3 phospholipase A2, group III JBrowse link 14 83,724,828 83,730,614 RGD:6907045
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:6907045
G Pla2g4b phospholipase A2 group IVB JBrowse link 3 111,824,919 111,833,526 RGD:6907045
G Pla2g4e phospholipase A2, group IVE JBrowse link 3 111,952,396 112,018,470 RGD:6907045
G Pla2g4f phospholipase A2, group IVF JBrowse link 3 112,068,617 112,083,978 RGD:6907045
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:6907045
G Pla2g6 phospholipase A2 group VI JBrowse link 7 120,519,479 120,559,716 RGD:6907045
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:6907045
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:6907045
G Plcb3 phospholipase C beta 3 JBrowse link 1 222,207,887 222,224,993 RGD:6907045
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6907045
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link 10 37,534,449 37,554,861 RGD:6907045
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:6907045
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha JBrowse link 1 60,717,386 60,736,629 RGD:6907045
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta JBrowse link 8 55,279,278 55,311,768 RGD:6907045
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:6907045
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:6907045
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:6907045
G Prkg1 protein kinase cGMP-dependent 1 JBrowse link 1 248,982,039 250,300,952 RGD:6907045
G Prkg2 protein kinase cGMP-dependent 2 JBrowse link 14 12,217,121 12,313,616 RGD:6907045
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:6907045

Term paths to the root
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Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      signaling pathway pertinent to the brain and nervous system 460
        neuron-to-neuron signaling pathways 281
          neuron-to-neuron signaling pathway via the chemical synapse 279
            excitatory synaptic transmission pathway 191
              long term depression 71
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.