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ONTOLOGY REPORT - ANNOTATIONS


Term:G1/S DNA damage checkpoint pathway
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Accession:PW:0000095 term browser browse the term
Definition:Those pathways of DNA damage response that occur during the G1 phase.


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G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccne1 cyclin E1 JBrowse link NW_004955468 7,803,610 7,814,872 RGD:9068941
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link NW_004955412 29,433,730 29,602,389 RGD:9068941
G Mdm2 MDM2 proto-oncogene JBrowse link NW_004955458 15,264,028 15,287,290 RGD:9068941
G Mdm4 MDM4 regulator of p53 JBrowse link NW_004955406 40,346,617 40,387,977 RGD:9068941
G Nfya nuclear transcription factor Y subunit alpha JBrowse link NW_004955437 7,745,182 7,770,348 RGD:9068941
G Nfyb nuclear transcription factor Y subunit beta JBrowse link NW_004955405 38,773,690 38,789,534 RGD:9068941
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link NW_004955537 544,534 611,459 RGD:9068941
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link NW_004955495 1,250,557 1,261,617 RGD:9068941
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link NW_004955413 27,271,717 27,326,655 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004955467 9,241,391 9,256,716 RGD:9068941
G Tp63 tumor protein p63 JBrowse link NW_004955420 18,178,639 18,384,786 RGD:9068941
G Tp73 tumor protein p73 JBrowse link NW_004955486 7,914,608 7,961,992 RGD:9068941
G Vdr vitamin D receptor JBrowse link NW_004955500 6,745,725 6,798,052 RGD:9068941
p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link NW_004955513 652,048 799,182 RGD:9068941
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link NW_004955454 1,250,261 1,313,547 RGD:9068941
G Akt1 AKT serine/threonine kinase 1 JBrowse link NW_004955538 3,208,711 3,224,386 RGD:9068941
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link NW_004955405 34,619,780 34,693,616 RGD:9068941
G Atm ATM serine/threonine kinase JBrowse link NW_004955412 10,422,753 10,531,406 RGD:9068941
G Atr ATR serine/threonine kinase JBrowse link NW_004955508 3,337,036 3,440,313 RGD:9068941
G Bax BCL2 associated X, apoptosis regulator JBrowse link NW_004955559 1,695,960 1,700,246 RGD:9068941
G Bbc3 BCL2 binding component 3 JBrowse link NW_004955574 1,167,790 1,174,966 RGD:9068941
G Bid BH3 interacting domain death agonist JBrowse link NW_004955454 5,776,656 5,785,500 RGD:9068941
G Brca1 BRCA1 DNA repair associated JBrowse link NW_004955451 16,819,463 16,870,780 RGD:9068941
G Casp3 caspase 3 JBrowse link NW_004955403 24,315,712 24,326,271 RGD:9068941
G Casp8 caspase 8 JBrowse link NW_004955403 322,082 348,591 RGD:9068941
G Casp9 caspase 9 JBrowse link NW_004955527 2,613,691 2,630,217 RGD:9068941
G Ccna2 cyclin A2 JBrowse link NW_004955428 18,725,969 18,732,478 RGD:9068941
G Ccnb1 cyclin B1 JBrowse link NW_004955446 140,661 149,500 RGD:9068941
G Ccnb2 cyclin B2 JBrowse link NW_004955450 15,558,874 15,587,456 RGD:9068941
G Ccnb3 cyclin B3 JBrowse link NW_004955543 1,377,932 1,444,327 RGD:9068941
G Ccnd1 cyclin D1 JBrowse link NW_004955422 16,449,921 16,462,676 RGD:9068941
G Ccnd2 cyclin D2 JBrowse link NW_004955413 2,083,351 2,108,450 RGD:9068941
G Ccnd3 cyclin D3 JBrowse link NW_004955437 8,266,523 8,273,855 RGD:9068941
G Ccne1 cyclin E1 JBrowse link NW_004955468 7,803,610 7,814,872 RGD:9068941
G Ccne2 cyclin E2 JBrowse link NW_004955417 11,027,749 11,039,945 RGD:9068941
G Ccng1 cyclin G1 JBrowse link NW_004955408 16,846,050 16,850,365 RGD:9068941
G Ccng2 cyclin G2 JBrowse link NW_004955433 1,799,405 1,807,050 RGD:9068941
G Cd82 CD82 molecule JBrowse link NW_004955422 3,035,887 3,069,298 RGD:9068941
G Cdk1 cyclin dependent kinase 1 JBrowse link NW_004955425 14,210,681 14,226,474 RGD:9068941
G Cdk2 cyclin dependent kinase 2 JBrowse link NW_004955458 3,555,603 3,561,063 RGD:9068941
G Cdk4 cyclin dependent kinase 4 JBrowse link NW_004955458 5,457,927 5,460,718 RGD:9068941
G Cdk6 cyclin dependent kinase 6 JBrowse link NW_004955432 9,521,794 9,727,772 RGD:9068941
G Cdkn1a cyclin dependent kinase inhibitor 1A JBrowse link NW_004955437 6,254,638 6,261,278 RGD:9068941
G Chek1 checkpoint kinase 1 JBrowse link NW_004955412 26,627,606 26,650,554 RGD:9068941
G Chek2 checkpoint kinase 2 JBrowse link NW_004955455 2,969,113 3,008,004 RGD:9068941
G Cop1 COP1 E3 ubiquitin ligase JBrowse link NW_004955406 15,662,546 15,859,306 RGD:9068941
G Crebbp CREB binding protein JBrowse link NW_004955442 13,559,496 13,691,913 RGD:9068941
G Cse1l chromosome segregation 1 like JBrowse link NW_004955445 9,012,953 9,053,852 RGD:9068941
G Csnk1a1 casein kinase 1 alpha 1 JBrowse link NW_004955415 4,921,356 4,966,705 RGD:9068941
G Csnk1d casein kinase 1 delta JBrowse link NW_004955506 904,659 936,293 RGD:9068941
G Csnk1e casein kinase 1 epsilon JBrowse link NW_004955413 24,560,889 24,591,669 RGD:9068941
G Csnk1g1 casein kinase 1 gamma 1 JBrowse link NW_004955450 11,088,601 11,239,227 RGD:9068941
G Csnk1g2 casein kinase 1 gamma 2 JBrowse link NW_004955495 6,087,159 6,103,413 RGD:9068941
G Csnk1g3 casein kinase 1 gamma 3 JBrowse link NW_004955521 1,660,090 1,721,811 RGD:9068941
G Daxx death domain associated protein JBrowse link NW_004955437 1,869,692 1,874,041 RGD:9068941
G Ddb2 damage specific DNA binding protein 2 JBrowse link NW_004955422 961,602 977,066 RGD:9068941
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link NW_004955458 14,199,912 14,201,712 RGD:9068941
G E4f1 E4F transcription factor 1 JBrowse link NW_004955442 15,031,210 15,041,437 RGD:9068941
G Ei24 EI24 autophagy associated transmembrane protein JBrowse link NW_004955412 26,574,814 26,586,154 RGD:9068941
G Ep300 E1A binding protein p300 JBrowse link NW_004955413 26,647,553 26,727,875 RGD:9068941
G Fas Fas cell surface death receptor JBrowse link NW_004955425 3,961,671 3,987,513 RGD:9068941
G Fbxo11 F-box protein 11 JBrowse link NW_004955441 14,471,283 14,495,508 RGD:9068941
G Gadd45a growth arrest and DNA damage inducible alpha JBrowse link NW_004955423 23,656,516 23,658,367 RGD:9068941
G Gadd45b growth arrest and DNA damage inducible beta JBrowse link NW_004955495 4,864,932 4,866,728 RGD:9068941
G Gadd45g growth arrest and DNA damage inducible gamma JBrowse link NW_004955515 2,423,137 2,424,851 RGD:9068941
G Gsk3b glycogen synthase kinase 3 beta JBrowse link NW_004955427 19,489,972 19,671,137 RGD:9068941
G Gtse1 G2 and S-phase expressed 1 JBrowse link NW_004955413 30,414,007 30,438,363 RGD:9068941
G Hdac1 histone deacetylase 1 JBrowse link NW_004955452 10,636,366 10,668,873 RGD:9068941
G Hipk2 homeodomain interacting protein kinase 2 JBrowse link NW_004955494 3,365,826 3,554,735 RGD:9068941
G Huwe1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link NW_004955475 550,643 671,771 RGD:9068941
G Igf1 insulin like growth factor 1 JBrowse link NW_004955405 37,505,830 37,582,152 RGD:9068941
G Igfbp3 insulin like growth factor binding protein 3 JBrowse link NW_004955456 6,795,560 6,802,147 RGD:9068941
G Kat2a lysine acetyltransferase 2A JBrowse link NW_004955451 16,192,228 16,197,103 RGD:9068941
G Kat2b lysine acetyltransferase 2B JBrowse link NW_004955430 12,109,493 12,196,102 RGD:9068941
G Kat5 lysine acetyltransferase 5 JBrowse link NW_004955422 19,557,498 19,565,044 RGD:9068941
G Kmt5a lysine methyltransferase 5A JBrowse link NW_004955482 5,488,151 5,500,764 RGD:9068941
G LOC102023786 cytochrome c, somatic JBrowse link NW_004955410 27,086,405 27,089,255 RGD:9068941
G Mapk14 mitogen-activated protein kinase 14 JBrowse link NW_004955437 3,836,331 3,884,083 RGD:9068941
G Mapk8 mitogen-activated protein kinase 8 JBrowse link NW_004955556 1,593,552 1,705,543 RGD:9068941
G Mapk9 mitogen-activated protein kinase 9 JBrowse link NW_004955408 391,094 430,638 RGD:9068941
G Mdm2 MDM2 proto-oncogene JBrowse link NW_004955458 15,264,028 15,287,290 RGD:9068941
G Mdm4 MDM4 regulator of p53 JBrowse link NW_004955406 40,346,617 40,387,977 RGD:9068941
G Muc1 mucin 1, cell surface associated JBrowse link NW_004955545 1,657,728 1,662,112 RGD:9068941
G Nedd8 NEDD8 ubiquitin like modifier JBrowse link NW_004955409 36,173,533 36,182,444 RGD:9068941
G Perp p53 apoptosis effector related to PMP22 JBrowse link NW_004955436 21,425,321 21,430,780 RGD:9068941
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link NW_004955495 1,250,557 1,261,617 RGD:9068941
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link NW_004955402 44,005,517 44,010,722 RGD:9068941
G Pou4f1 POU class 4 homeobox 1 JBrowse link NW_004955404 28,812,762 28,818,024 RGD:9068941
G Pou4f2 POU class 4 homeobox 2 JBrowse link NW_004955428 2,325,775 2,329,122 RGD:9068941
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link NW_004955451 1,878,110 1,915,794 RGD:9068941
G Ppp1r13b protein phosphatase 1 regulatory subunit 13B JBrowse link NW_004955538 2,519,765 2,594,769 RGD:9068941
G Ppp1r13l protein phosphatase 1 regulatory subunit 13 like JBrowse link NW_004955555 2,373,088 2,390,973 RGD:9068941
G Ppp2ca protein phosphatase 2 catalytic subunit alpha JBrowse link NW_004955408 5,435,117 5,460,361 RGD:9068941
G Prkcd protein kinase C delta JBrowse link NW_004955430 3,125,066 3,151,857 RGD:9068941
G Prmt5 protein arginine methyltransferase 5 JBrowse link NW_004955409 37,369,507 37,378,034 RGD:9068941
G Pten phosphatase and tensin homolog JBrowse link NW_004955425 5,007,811 5,091,829 RGD:9068941
G Ptpa protein phosphatase 2 phosphatase activator JBrowse link NW_004955570 1,429,316 1,454,820 RGD:9068941
G Rassf1 Ras association domain family member 1 JBrowse link NW_004955532 2,132,892 2,142,106 RGD:9068941
G Rchy1 ring finger and CHY zinc finger domain containing 1 JBrowse link NW_004955474 1,463,817 1,475,677 RGD:9068941
G Rpl11 ribosomal protein L11 JBrowse link NW_004955452 3,626,609 3,630,911 RGD:9068941
G Rpl23 ribosomal protein L23 JBrowse link NW_004955451 13,892,880 13,898,079 RGD:9068941
G Rpl5 ribosomal protein L5 JBrowse link NW_004955423 1,748,809 1,758,622 RGD:9068941
G Rrm2 ribonucleotide reductase regulatory subunit M2 JBrowse link NW_004955487 5,477,097 5,481,422 RGD:9068941
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link NW_004955417 26,949,686 26,976,976 RGD:9068941
G Serpinb5 serpin family B member 5 JBrowse link NW_004955402 47,248,665 47,276,017 RGD:9068941
G Serpine1 serpin family E member 1 JBrowse link NW_004955456 16,147,523 16,157,040 RGD:9068941
G Sesn1 sestrin 1 JBrowse link NW_004955411 34,033,986 34,051,171 RGD:9068941
G Sesn2 sestrin 2 JBrowse link NW_004955452 7,392,644 7,417,204 RGD:9068941
G Sesn3 sestrin 3 JBrowse link NW_004955412 100,335 125,395 RGD:9068941
G Setd7 SET domain containing 7, histone lysine methyltransferase JBrowse link NW_004955428 4,131,431 4,178,250 RGD:9068941
G Sfn stratifin JBrowse link NW_004955452 6,217,519 6,218,481 RGD:9068941
G Shisa5 shisa family member 5 JBrowse link NW_004955532 535,992 544,542 RGD:9068941
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link NW_004955474 6,970,383 6,982,231 RGD:9068941
G Sirt1 sirtuin 1 JBrowse link NW_004955425 20,280,725 20,307,663 RGD:9068941
G Skp2 S-phase kinase associated protein 2 JBrowse link NW_004955426 20,972,663 20,999,769 RGD:9068941
G Smyd2 SET and MYND domain containing 2 JBrowse link NW_004955406 3,467,123 3,509,156 RGD:9068941
G Steap3 STEAP3 metalloreductase JBrowse link NW_004955459 10,441,906 10,485,235 RGD:9068941
G Thbs1 thrombospondin 1 JBrowse link NW_004955416 6,490,034 6,506,419 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004955467 9,241,391 9,256,716 RGD:9068941
G Tp53bp2 tumor protein p53 binding protein 2 JBrowse link NW_004955520 1,254,853 1,285,118 RGD:9068941
G Tp53i3 tumor protein p53 inducible protein 3 JBrowse link NW_004955469 6,287,442 6,298,944 RGD:9068941
G Tp73 tumor protein p73 JBrowse link NW_004955486 7,914,608 7,961,992 RGD:9068941
G Trim28 tripartite motif containing 28 JBrowse link NW_004955584 1,148,903 1,156,001 RGD:9068941
G Tsc2 TSC complex subunit 2 JBrowse link NW_004955442 15,178,356 15,216,978 RGD:9068941
G Ttc5 tetratricopeptide repeat domain 5 JBrowse link NW_004955550 1,073,697 1,105,055 RGD:9068941
G Ube2d1 ubiquitin conjugating enzyme E2 D1 JBrowse link NW_004955425 12,073,267 12,090,613 RGD:9068941
G Usp7 ubiquitin specific peptidase 7 JBrowse link NW_004955442 9,316,022 9,355,751 RGD:9068941
G Ybx1 Y-box binding protein 1 JBrowse link NW_004955537 2,234,052 2,254,528 RGD:9068941
G Yy1 YY1 transcription factor JBrowse link NW_004955438 21,341,374 21,377,674 RGD:9068941
G Zmat3 zinc finger matrin-type 3 JBrowse link NW_004955420 8,270,026 8,301,313 RGD:9068941
G Znf385a zinc finger protein 385A JBrowse link NW_004955458 1,610,245 1,631,639 RGD:9068941
G Znhit1 zinc finger HIT-type containing 1 JBrowse link NW_004955456 16,070,622 16,082,286 RGD:9068941
p53-dependent G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccne1 cyclin E1 JBrowse link NW_004955468 7,803,610 7,814,872 RGD:9068941
G Tp53 tumor protein p53 JBrowse link NW_004955467 9,241,391 9,256,716 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5435
    regulatory pathway 3344
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1594
        cell cycle pathway 219
          cell cycle checkpoint pathway 127
            G1/S DNA damage checkpoint pathway 126
              p53-dependent G1/S DNA damage checkpoint pathway + 126
              p53-independent G1/S DNA damage checkpoint pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.