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ONTOLOGY REPORT - ANNOTATIONS


Term:G1/S DNA damage checkpoint pathway
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Accession:PW:0000095 term browser browse the term
Definition:Those pathways of DNA damage response that occur during the G1 phase.


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G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCNE1 cyclin E1 JBrowse link 19 29,811,991 29,824,312 RGD:1358139
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ETS1 ETS proto-oncogene 1, transcription factor JBrowse link 11 128,458,761 128,587,593 RGD:8663430
G MDM2 MDM2 proto-oncogene JBrowse link 12 68,808,149 68,850,686 RGD:2316186
RGD:8663434
G MDM4 MDM4 regulator of p53 JBrowse link 1 204,516,377 204,558,120 RGD:8663434
G MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 11 94,415,570 94,512,701 RGD:8663431
G NFYA nuclear transcription factor Y subunit alpha JBrowse link 6 41,072,974 41,102,403 RGD:8663431
RGD:8663430
G NFYB nuclear transcription factor Y subunit beta JBrowse link 12 104,117,086 104,138,241 RGD:8663431
RGD:8663430
G NFYC nuclear transcription factor Y subunit gamma JBrowse link 1 40,691,699 40,771,603 RGD:8663431
RGD:8663430
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 19 9,835,207 9,849,689 RGD:8663430
G SREBF2 sterol regulatory element binding transcription factor 2 JBrowse link 22 41,833,105 41,907,308 RGD:8663431
RGD:8663430
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:2316186
RGD:8693397
RGD:8663430
RGD:8663431
RGD:5490966
RGD:5133242
RGD:4143515
G TP63 tumor protein p63 JBrowse link 3 189,596,746 189,897,279 RGD:8663431
RGD:8663430
G TP73 tumor protein p73 JBrowse link 1 3,652,516 3,736,201 RGD:8663431
RGD:8663430
G VDR vitamin D receptor JBrowse link 12 47,841,537 47,905,022 RGD:8663430
p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 9 130,713,881 130,887,675 RGD:6484113
RGD:8662965
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 8 142,449,649 142,545,009 RGD:6907045
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 104,769,349 104,795,748 RGD:6484113
G APAF1 apoptotic peptidase activating factor 1 JBrowse link 12 98,645,141 98,735,433 RGD:6907045
G ATM ATM serine/threonine kinase JBrowse link 11 108,222,484 108,369,102 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G ATR ATR serine/threonine kinase JBrowse link 3 142,449,235 142,578,793 RGD:6484113
RGD:6907045
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 48,954,825 48,961,798 RGD:6907045
G BBC3 BCL2 binding component 3 JBrowse link 19 47,220,822 47,232,998 RGD:6907045
G BID BH3 interacting domain death agonist JBrowse link 22 17,734,138 17,774,665 RGD:6907045
G BRCA1 BRCA1 DNA repair associated JBrowse link 17 43,044,295 43,125,364 RGD:8662965
G CASP3 caspase 3 JBrowse link 4 184,627,696 184,649,475 RGD:6907045
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6907045
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6907045
G CCNA2 cyclin A2 JBrowse link 4 121,816,444 121,823,883 RGD:6484113
G CCNB1 cyclin B1 JBrowse link 5 69,167,010 69,178,245 RGD:6907045
G CCNB2 cyclin B2 JBrowse link 15 59,105,146 59,125,045 RGD:6907045
G CCNB3 cyclin B3 JBrowse link X 50,202,713 50,351,914 RGD:6907045
G CCND1 cyclin D1 JBrowse link 11 69,641,156 69,654,474 RGD:6907045
G CCND2 cyclin D2 JBrowse link 12 4,273,762 4,305,353 RGD:6907045
G CCND3 cyclin D3 JBrowse link 6 41,934,933 42,048,894 RGD:6907045
G CCNE1 cyclin E1 JBrowse link 19 29,811,991 29,824,312 RGD:6907045
G CCNE2 cyclin E2 JBrowse link 8 94,880,224 94,896,671 RGD:6907045
G CCNG1 cyclin G1 JBrowse link 5 163,437,571 163,448,199 RGD:6484113
RGD:6907045
G CCNG2 cyclin G2 JBrowse link 4 77,157,207 77,170,060 RGD:6907045
G CD82 CD82 molecule JBrowse link 11 44,565,610 44,620,363 RGD:6907045
G CDK1 cyclin dependent kinase 1 JBrowse link 10 60,778,331 60,794,852 RGD:6907045
G CDK2 cyclin dependent kinase 2 JBrowse link 12 55,966,830 55,972,789 RGD:6484113
RGD:6907045
G CDK4 cyclin dependent kinase 4 JBrowse link 12 57,747,727 57,752,310 RGD:6907045
G CDK6 cyclin dependent kinase 6 JBrowse link 7 92,604,921 92,836,573 RGD:6907045
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:6907045
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 21,967,752 21,995,324 RGD:6907045
G CHEK1 checkpoint kinase 1 JBrowse link 11 125,624,910 125,676,256 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G CHEK2 checkpoint kinase 2 JBrowse link 22 28,687,743 28,741,866 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G COP1 COP1 E3 ubiquitin ligase JBrowse link 1 175,944,826 176,209,087 RGD:2316155
RGD:6907045
RGD:6484113
G CREBBP CREB binding protein JBrowse link 16 3,725,054 3,880,727 RGD:2316155
RGD:8662965
RGD:6484113
G CSE1L chromosome segregation 1 like JBrowse link 20 49,046,246 49,096,960 RGD:6484113
G CSNK1A1 casein kinase 1 alpha 1 JBrowse link 5 149,492,982 149,551,439 RGD:6484113
G CSNK1D casein kinase 1 delta JBrowse link 17 82,239,019 82,273,750 RGD:6484113
G CSNK1E casein kinase 1 epsilon JBrowse link 22 38,290,691 38,318,084 RGD:6484113
G CSNK1G1 casein kinase 1 gamma 1 JBrowse link 15 64,165,525 64,356,173 RGD:6484113
G CSNK1G2 casein kinase 1 gamma 2 JBrowse link 19 1,941,149 1,981,338 RGD:6484113
G CSNK1G3 casein kinase 1 gamma 3 JBrowse link 5 123,512,099 123,617,049 RGD:6484113
G CYCS cytochrome c, somatic JBrowse link 7 25,118,656 25,125,260 RGD:6907045
G DAXX death domain associated protein JBrowse link 6 33,318,558 33,323,016 RGD:6484113
G DDB2 damage specific DNA binding protein 2 JBrowse link 11 47,214,942 47,239,218 RGD:6907045
G DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 12 67,648,745 67,665,406 RGD:6484113
G E4F1 E4F transcription factor 1 JBrowse link 16 2,223,488 2,235,742 RGD:6484113
G EI24 EI24 autophagy associated transmembrane protein JBrowse link 11 125,569,216 125,584,684 RGD:6907045
G EP300 E1A binding protein p300 JBrowse link 22 41,092,592 41,180,077 RGD:6484113
G FAS Fas cell surface death receptor JBrowse link 10 88,968,429 89,017,059 RGD:6907045
G FBXO11 F-box protein 11 JBrowse link 2 47,806,920 47,906,498 RGD:6484113
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 67,685,201 67,688,334 RGD:6907045
G GADD45B growth arrest and DNA damage inducible beta JBrowse link 19 2,476,127 2,478,259 RGD:6907045
G GADD45G growth arrest and DNA damage inducible gamma JBrowse link 9 89,605,009 89,606,555 RGD:6907045
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 119,821,321 120,095,823 RGD:6484113
G GTSE1 G2 and S-phase expressed 1 JBrowse link 22 46,295,143 46,333,699 RGD:6907045
G HDAC1 histone deacetylase 1 JBrowse link 1 32,292,083 32,333,628 RGD:2316155
G HIPK2 homeodomain interacting protein kinase 2 JBrowse link 7 139,561,570 139,777,998 RGD:6484113
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 53,532,096 53,686,723 RGD:6484113
G IGF1 insulin like growth factor 1 JBrowse link 12 102,395,860 102,481,839 RGD:6907045
G IGFBP3 insulin like growth factor binding protein 3 JBrowse link 7 45,912,245 45,921,272 RGD:6907045
G KAT2A lysine acetyltransferase 2A JBrowse link 17 42,113,111 42,121,367 RGD:8662965
G KAT2B lysine acetyltransferase 2B JBrowse link 3 20,040,407 20,154,404 RGD:6484113
RGD:8662965
G KAT5 lysine acetyltransferase 5 JBrowse link 11 65,712,018 65,719,604 RGD:2316155
RGD:8662965
RGD:6484113
G KAT8 lysine acetyltransferase 8 JBrowse link 16 31,117,664 31,131,393 RGD:2316155
RGD:6484113
G KMT5A lysine methyltransferase 5A JBrowse link 12 123,384,132 123,409,353 RGD:6484113
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 6 36,027,677 36,122,964 RGD:6484113
G MAPK8 mitogen-activated protein kinase 8 JBrowse link 10 48,306,639 48,439,360 RGD:6484113
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 5 180,233,143 180,292,083 RGD:6484113
G MDM2 MDM2 proto-oncogene JBrowse link 12 68,808,149 68,850,686 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G MDM4 MDM4 regulator of p53 JBrowse link 1 204,516,377 204,558,120 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G MUC1 mucin 1, cell surface associated JBrowse link 1 155,185,824 155,192,915 RGD:8662965
G NEDD8 NEDD8 ubiquitin like modifier JBrowse link 14 24,216,857 24,232,367 RGD:6484113
G PERP p53 apoptosis effector related to PMP22 JBrowse link 6 138,088,505 138,107,419 RGD:6907045
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 19 9,835,207 9,849,689 RGD:6484113
RGD:8662965
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 59,899,996 59,904,305 RGD:6907045
G POU4F1 POU class 4 homeobox 1 JBrowse link 13 78,598,362 78,603,552 RGD:8662965
G POU4F2 POU class 4 homeobox 2 JBrowse link 4 146,638,893 146,642,474 RGD:8662965
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 17 60,600,187 60,666,280 RGD:6484113
RGD:6907045
G PPP1R13B protein phosphatase 1 regulatory subunit 13B JBrowse link 14 103,733,195 103,849,327 RGD:8662965
G PPP1R13L protein phosphatase 1 regulatory subunit 13 like JBrowse link 19 45,379,634 45,406,361 RGD:6484113
RGD:8662965
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 5 134,194,332 134,226,073 RGD:6484113
G PRKCD protein kinase C delta JBrowse link 3 53,161,209 53,192,717 RGD:6484113
G PRMT5 protein arginine methyltransferase 5 JBrowse link 14 22,920,526 22,929,392 RGD:6484113
G PTEN phosphatase and tensin homolog JBrowse link 10 87,863,625 87,971,930 RGD:6907045
G PTPA protein phosphatase 2 phosphatase activator JBrowse link 9 129,110,949 129,148,946 RGD:6484113
G RASSF1 Ras association domain family member 1 JBrowse link 3 50,329,786 50,340,936 RGD:6484113
G RCHY1 ring finger and CHY zinc finger domain containing 1 JBrowse link 4 75,479,037 75,515,057 RGD:2316155
RGD:6907045
RGD:6484113
G RPL11 ribosomal protein L11 JBrowse link 1 23,691,779 23,696,835 RGD:6484113
G RPL23 ribosomal protein L23 JBrowse link 17 38,847,860 38,853,721 RGD:6484113
G RPL5 ribosomal protein L5 JBrowse link 1 92,831,986 92,841,924 RGD:6484113
G RPRM reprimo, TP53 dependent G2 arrest mediator homolog JBrowse link 2 153,477,338 153,478,762 RGD:6907045
G RRM2 ribonucleotide reductase regulatory subunit M2 JBrowse link 2 10,122,568 10,211,010 RGD:6907045
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 8 102,204,501 102,238,961 RGD:6907045
G SERPINB5 serpin family B member 5 JBrowse link 18 63,476,958 63,505,085 RGD:6907045
G SERPINE1 serpin family E member 1 JBrowse link 7 101,127,104 101,139,247 RGD:6907045
G SESN1 sestrin 1 JBrowse link 6 108,984,309 109,094,846 RGD:6907045
G SESN2 sestrin 2 JBrowse link 1 28,259,452 28,282,491 RGD:6907045
G SESN3 sestrin 3 JBrowse link 11 95,165,513 95,232,536 RGD:6907045
G SETD7 SET domain containing 7, histone lysine methyltransferase JBrowse link 4 139,495,934 139,556,769 RGD:2316155
RGD:6484113
G SFN stratifin JBrowse link 1 26,863,149 26,864,456 RGD:6907045
G SHISA5 shisa family member 5 JBrowse link 3 48,467,798 48,504,826 RGD:6907045
G SIAH1 siah E3 ubiquitin protein ligase 1 JBrowse link 16 48,354,581 48,448,435 RGD:6907045
G SIRT1 sirtuin 1 JBrowse link 10 67,884,656 67,918,390 RGD:2316155
G SKP2 S-phase kinase associated protein 2 JBrowse link 5 36,152,043 36,184,319 RGD:6484113
G SMYD2 SET and MYND domain containing 2 JBrowse link 1 214,281,159 214,337,136 RGD:2316155
RGD:6484113
G STEAP3 STEAP3 metalloreductase JBrowse link 2 119,222,476 119,265,652 RGD:6907045
G THBS1 thrombospondin 1 JBrowse link 15 39,581,079 39,599,466 RGD:6907045
G TNFRSF10B TNF receptor superfamily member 10b JBrowse link 8 23,020,133 23,069,031 RGD:6907045
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:2316155
RGD:6907045
RGD:6484113
RGD:2316156
G TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 JBrowse link 11 128,934,732 128,944,233 RGD:6484113
RGD:6907045
G TP53BP2 tumor protein p53 binding protein 2 JBrowse link 1 223,779,893 223,845,972 RGD:8662965
G TP53I3 tumor protein p53 inducible protein 3 JBrowse link 2 24,077,428 24,085,767 RGD:6907045
G TP73 tumor protein p73 JBrowse link 1 3,652,516 3,736,201 RGD:6907045
G TRIM28 tripartite motif containing 28 JBrowse link 19 58,544,064 58,550,722 RGD:6484113
G TSC2 TSC complex subunit 2 JBrowse link 16 2,047,804 2,089,491 RGD:6907045
G TTC5 tetratricopeptide repeat domain 5 JBrowse link 14 20,286,227 20,305,951 RGD:6484113
G UBE2D1 ubiquitin conjugating enzyme E2 D1 JBrowse link 10 58,334,979 58,370,753 RGD:6484113
G USP7 ubiquitin specific peptidase 7 JBrowse link 16 8,892,094 8,963,912 RGD:2316155
RGD:6484113
G YBX1 Y-box binding protein 1 JBrowse link 1 42,682,418 42,703,805 RGD:8662965
G YY1 YY1 transcription factor JBrowse link 14 100,239,144 100,282,788 RGD:6484113
G ZMAT3 zinc finger matrin-type 3 JBrowse link 3 179,017,223 179,072,513 RGD:6907045
G ZNF385A zinc finger protein 385A JBrowse link 12 54,369,134 54,391,610 RGD:8662965
G ZNF420 zinc finger protein 420 JBrowse link 19 37,007,815 37,130,368 RGD:8662965
G ZNHIT1 zinc finger HIT-type containing 1 JBrowse link 7 101,218,165 101,224,191 RGD:8662965
p53-dependent G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCNE1 cyclin E1 JBrowse link 19 29,811,991 29,824,312 RGD:1358139
G TP53 tumor protein p53 JBrowse link 17 7,668,402 7,687,550 RGD:1358139

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5944
    regulatory pathway 3597
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1645
        cell cycle pathway 228
          cell cycle checkpoint pathway 134
            G1/S DNA damage checkpoint pathway 133
              p53-dependent G1/S DNA damage checkpoint pathway + 133
              p53-independent G1/S DNA damage checkpoint pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.