Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:folate mediated one-carbon metabolic pathway
go back to main search page
Accession:PW:0000189 term browser browse the term
Definition:Folate mediated one-carbon metabolism represents the one-carbon transfer reactions important for de novo purine and thymidylate biosynthesis and for the remethylation of methionine in the methionine cycle and homocysteine metabolism. The methionine cycle also produces the major methyl donor for proteins, nucleic acids, lipids and other small molecules. The folate mediated one-carbon transfer and the folate cycle pathways are part of folate metabolism.
Synonyms:related_synonym: KEGG:00670

View Interactive Diagram


show annotations for term's descendants       view all columns           Sort by:
 
folate mediated one-carbon metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALDH1L1 aldehyde dehydrogenase 1 family member L1 JBrowse link 3 126,103,561 126,197,758 RGD:6907045
G ALDH1L2 aldehyde dehydrogenase 1 family member L2 JBrowse link 12 105,019,784 105,084,609 RGD:6907045
G AMT aminomethyltransferase JBrowse link 3 49,416,778 49,422,473 RGD:6907045
G ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase JBrowse link 2 215,311,974 215,359,745 RGD:6907045
RGD:7242561
RGD:70804
G DHFR dihydrofolate reductase JBrowse link 5 80,626,226 80,654,983 RGD:1298877
RGD:7242561
RGD:6907045
G DMGDH dimethylglycine dehydrogenase JBrowse link 5 78,997,564 79,069,674 RGD:1547831
G FOLH1 folate hydrolase 1 JBrowse link 11 49,145,092 49,208,642 RGD:728645
G FTCD formimidoyltransferase cyclodeaminase JBrowse link 21 46,135,981 46,156,482 RGD:6907045
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase JBrowse link 21 33,503,931 33,542,892 RGD:1547842
RGD:7242561
RGD:6907045
G GGH gamma-glutamyl hydrolase JBrowse link 8 63,015,079 63,038,806 RGD:69845
G MTFMT mitochondrial methionyl-tRNA formyltransferase JBrowse link 15 65,001,512 65,029,639 RGD:6907045
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 14 64,388,353 64,460,025 RGD:6907045
RGD:7242561
RGD:1299513
G MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like JBrowse link 6 150,865,679 151,101,887 RGD:6907045
G MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase JBrowse link 2 74,198,563 74,217,565 RGD:1540378
RGD:6907045
G MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like JBrowse link 4 74,123,273 74,303,099 RGD:6907045
G MTHFR methylenetetrahydrofolate reductase JBrowse link 1 11,785,723 11,806,103 RGD:1535021
RGD:7242561
RGD:6907045
G MTHFS methenyltetrahydrofolate synthetase JBrowse link 15 79,843,547 79,897,285 RGD:6907045
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 1 236,794,304 236,903,981 RGD:6907045
RGD:7242426
RGD:1359026
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase JBrowse link 5 7,851,186 7,901,124 RGD:7242426
G SARDH sarcosine dehydrogenase JBrowse link 9 133,663,074 133,739,958 RGD:634034
G SHMT1 serine hydroxymethyltransferase 1 JBrowse link 17 18,327,860 18,363,563 RGD:1359815
RGD:7242561
RGD:6907045
RGD:2300383
G SHMT2 serine hydroxymethyltransferase 2 JBrowse link 12 57,229,685 57,234,935 RGD:1359815
RGD:7242561
RGD:6907045
RGD:2300383
G TYMS thymidylate synthetase JBrowse link 18 657,653 673,578 RGD:6907045
RGD:7242561
RGD:1545055
altered folate mediated one-carbon metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 JBrowse link 14 64,388,353 64,460,025 RGD:7242562
G MTHFR methylenetetrahydrofolate reductase JBrowse link 1 11,785,723 11,806,103 RGD:7242562
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase JBrowse link 1 236,794,304 236,903,981 RGD:7242562

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5944
    classic metabolic pathway 1797
      metabolic pathway of cofactors, vitamins, nutrients 369
        folate metabolic pathway 42
          folate mediated one-carbon metabolic pathway 23
            altered folate mediated one-carbon metabolic pathway 3
Path 2
Term Annotations click to browse term
  pathway 5944
    regulatory pathway 3597
      homeostasis pathway 1659
        organic chemical homeostasis pathway 427
          S-adenosylmethionine homeostasis pathway 275
            folate metabolic pathway 42
              folate mediated one-carbon metabolic pathway 23
                altered folate mediated one-carbon metabolic pathway 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.