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ONTOLOGY REPORT - ANNOTATIONS


Term:Wnt signaling, canonical pathway
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Accession:PW:0000201 term browser browse the term
Definition:Wnt signaling pathway is involved in many developmental processes. In the conventional or canonical Wnt pathway, beta-catenin is a central component required for the transcriptional control of Wnt signaling target genes.
Synonyms:related_synonym: PID:200077;   beta-catenin dependent Wnt signaling pathway

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Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:2293188
RGD:6484113
G Axin1 axin 1 RGD:2293188
RGD:6484113
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:2293188
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:6484113
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:2302032
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:2293188
G Csnk1g1 casein kinase 1, gamma 1 JBrowse link 8 71,533,372 71,688,483 RGD:2293188
RGD:6484113
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1581696
RGD:7242068
RGD:6484113
RGD:2293188
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:6484113
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 JBrowse link 1 248,952,896 248,956,579 RGD:2293188
RGD:2301921
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 JBrowse link 2 237,148,918 237,240,883 RGD:2301921
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 JBrowse link 16 74,260,551 74,264,142 RGD:2301921
G Dvl1 dishevelled segment polarity protein 1 JBrowse link 5 173,295,948 173,308,014 RGD:1581696
RGD:6484113
G Dvl2 dishevelled segment polarity protein 2 JBrowse link 10 56,609,810 56,619,269 RGD:6484113
G Dvl3 dishevelled segment polarity protein 3 JBrowse link 11 84,051,177 84,068,479 RGD:6484113
G Frzb frizzled-related protein JBrowse link 3 67,635,604 67,668,772 RGD:7365107
G Fzd1 frizzled class receptor 1 JBrowse link 4 26,470,864 26,475,262 RGD:2293491
G Fzd5 frizzled class receptor 5 JBrowse link 9 71,443,784 71,445,541 RGD:6484113
G Gsk3a glycogen synthase kinase 3 alpha JBrowse link 1 82,097,244 82,108,238 RGD:6484113
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:1581696
RGD:7242068
RGD:6484113
RGD:2293188
G Klhl12 kelch-like family member 12 JBrowse link 13 51,280,933 51,314,753 RGD:6484113
G Kremen1 kringle containing transmembrane protein 1 JBrowse link 14 85,441,209 85,503,661 RGD:2301921
G Kremen2 kringle containing transmembrane protein 2 JBrowse link 10 13,076,042 13,081,210 RGD:2301921
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:2293188
RGD:2301908
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 JBrowse link 3 101,051,960 101,152,119 RGD:7365107
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 JBrowse link 7 58,447,097 58,587,787 RGD:7365107
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
RGD:2293491
G Lrp6 LDL receptor related protein 6 JBrowse link 4 168,194,054 168,323,962 RGD:2293188
RGD:6484113
G Ndp norrin cystine knot growth factor NDP JBrowse link X 6,791,090 6,815,586 RGD:7365107
G Nkd2 NKD inhibitor of WNT signaling pathway 2 JBrowse link 1 32,054,390 32,085,416 RGD:6484113
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha JBrowse link 1 261,337,594 261,362,509 RGD:6484113
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta JBrowse link 1 242,168,462 242,441,247 RGD:6484113
G Porcn porcupine O-acyltransferase JBrowse link X 15,035,569 15,048,440 RGD:7365109
G Ppp2r5a protein phosphatase 2, regulatory subunit B', alpha JBrowse link 13 110,033,550 110,077,946 RGD:6484113
G Ranbp3 RAN binding protein 3 JBrowse link 9 10,344,190 10,381,415 RGD:6484113
G Rnf43 ring finger protein 43 JBrowse link 10 74,956,411 75,028,951 RGD:7365105
G Rspo1 R-spondin 1 JBrowse link 5 142,986,526 143,007,847 RGD:7365105
G Rspo2 R-spondin 2 JBrowse link 7 81,919,911 82,059,659 RGD:7365105
G Rspo3 R-spondin 3 JBrowse link 1 30,681,648 30,768,038 RGD:7365105
G Rspo4 R-spondin 4 JBrowse link 3 147,358,690 147,391,719 RGD:7365105
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:7365107
G Sfrp2 secreted frizzled-related protein 2 JBrowse link 2 182,723,732 182,731,277 RGD:7365107
G Sfrp4 secreted frizzled-related protein 4 JBrowse link 17 47,383,983 47,394,065 RGD:7365107
G Sfrp5 secreted frizzled-related protein 5 JBrowse link 1 261,442,108 261,446,570 RGD:7365107
G Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 JBrowse link 8 22,648,323 22,739,468 RGD:2302032
G Sost sclerostin JBrowse link 10 89,897,087 89,900,131 RGD:7365107
G Sostdc1 sclerostin domain containing 1 JBrowse link 6 55,812,820 55,816,994 RGD:7365107
G Tcf7 transcription factor 7 JBrowse link 10 37,616,033 37,646,027 RGD:2301908
G Tcf7l1 transcription factor 7 like 1 JBrowse link 4 100,492,796 100,660,401 RGD:2301908
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:2301908
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1304267
G Wif1 Wnt inhibitory factor 1 JBrowse link 7 63,094,955 63,165,158 RGD:2293188
G Wls Wnt ligand secretion mediator JBrowse link 2 266,315,036 266,431,220 RGD:7365109
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:2313743
RGD:13209023
G Wnt10a Wnt family member 10A JBrowse link 9 82,053,581 82,066,047 RGD:2300202
RGD:2313743
G Wnt10b Wnt family member 10B JBrowse link 7 140,448,284 140,466,159 RGD:2300029
RGD:2313743
G Wnt11 Wnt family member 11 JBrowse link 1 163,794,136 163,813,756 RGD:2313743
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:2313743
G Wnt2 Wnt family member 2 JBrowse link 4 45,286,845 45,332,899 RGD:2313743
G Wnt2b Wnt family member 2B JBrowse link 2 207,433,771 207,457,094 RGD:2313743
G Wnt3 Wnt family member 3 JBrowse link 10 91,830,709 91,874,907 RGD:2313743
G Wnt3a Wnt family member 3A JBrowse link 10 45,598,898 45,643,151 RGD:2300202
RGD:6484113
RGD:2313743
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:2313743
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:2313743
G Wnt5b Wnt family member 5B JBrowse link 4 151,500,962 151,516,894 RGD:2313743
G Wnt6 Wnt family member 6 JBrowse link 9 82,033,543 82,047,172 RGD:2313743
G Wnt7a Wnt family member 7A JBrowse link 4 122,994,425 123,040,609 RGD:1601222
RGD:2313743
G Wnt7b Wnt family member 7B JBrowse link 7 126,423,418 126,465,724 RGD:1601222
RGD:2313743
RGD:2293491
G Wnt8a Wnt family member 8A JBrowse link 18 27,331,236 27,336,829 RGD:2313743
G Wnt8b Wnt family member 8B JBrowse link 1 264,244,150 264,266,136 RGD:2313743
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:2300156
RGD:2313743
G Wnt9b Wnt family member 9B JBrowse link 10 91,785,892 91,808,061 RGD:2313743
G Znrf3 zinc and ring finger 3 JBrowse link 14 85,527,099 85,586,294 RGD:7365105
altered Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:2293188
G Axin1 axin 1 RGD:2293188
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
RGD:4143515
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      signaling pathway pertinent to development 511
        Wnt signaling pathway 188
          Wnt signaling, canonical pathway 74
            altered Wnt signaling, canonical pathway 7
Path 2
Term Annotations click to browse term
  pathway 6016
    signaling pathway 2585
      glycoconjugated protein signaling pathway 403
        glycoprotein signaling pathway 294
          Wnt signaling pathway 188
            Wnt signaling, canonical pathway 74
              altered Wnt signaling, canonical pathway 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.