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ONTOLOGY REPORT - ANNOTATIONS


Term:vascular endothelial growth factor signaling pathway
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Accession:PW:0000243 term browser browse the term
Definition:The VEGF family plays key roles in angiogenesis and lymphangiogenesis. Through their receptors, VEGFs can initiate a diverse and complex network of signaling cascades. Deregulation of VEGFs mediated pathways, mostly through upregulation of VEGFs expression, has been implicated in a number of conditions, primarily cancer.
Synonyms:related_synonym: KEGG:04370;   PID:200109;   PID:200188;   VEGF signaling pathways

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vascular endothelial growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akap1 A kinase (PRKA) anchor protein 1 JBrowse link 11 88,830,792 88,864,596 RGD:6484113
G Akt1 thymoma viral proto-oncogene 1 JBrowse link 12 112,653,821 112,674,884 RGD:6484113
RGD:6907045
G Akt2 thymoma viral proto-oncogene 2 JBrowse link 7 27,591,552 27,640,826 RGD:6907045
G Akt3 thymoma viral proto-oncogene 3 JBrowse link 1 177,020,076 177,261,781 RGD:6907045
G Arf1 ADP-ribosylation factor 1 JBrowse link 11 59,211,412 59,228,267 RGD:6484113
G Bad BCL2-associated agonist of cell death JBrowse link 19 6,941,861 6,951,905 RGD:6907045
G Braf Braf transforming gene JBrowse link 6 39,603,231 39,725,658 RGD:6484113
G Calm1 calmodulin 1 JBrowse link 12 100,199,435 100,209,824 RGD:6484113
G Calm2 calmodulin 2 JBrowse link 17 87,433,401 87,446,935 RGD:6484113
G Calm3 calmodulin 3 JBrowse link 7 16,915,379 16,924,032 RGD:6484113
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta JBrowse link 5 122,718,380 122,779,522 RGD:6484113
G Casp9 caspase 9 JBrowse link 4 141,793,612 141,815,978 RGD:6907045
G Cav1 caveolin 1, caveolae protein JBrowse link 6 17,306,335 17,341,328 RGD:6484113
G Cbl Casitas B-lineage lymphoma JBrowse link 9 44,142,976 44,234,259 RGD:6484113
G Ccl2 chemokine (C-C motif) ligand 2 JBrowse link 11 82,035,577 82,037,452 RGD:1580560
G Cdc42 cell division cycle 42 JBrowse link 4 137,319,696 137,357,759 RGD:6484113
RGD:6907045
G Cdh5 cadherin 5 JBrowse link 8 104,101,613 104,144,504 RGD:6484113
G Chp1 calcineurin-like EF hand protein 1 JBrowse link 2 119,547,707 119,587,024 RGD:6907045
G Chp2 calcineurin-like EF hand protein 2 JBrowse link 7 122,208,621 122,222,539 RGD:6907045
G Ctnnb1 catenin (cadherin associated protein), beta 1 JBrowse link 9 120,933,400 120,960,507 RGD:6484113
G Dnm2 dynamin 2 JBrowse link 9 21,424,908 21,507,759 RGD:6484113
G Fbxw11 F-box and WD-40 domain protein 11 JBrowse link 11 32,642,555 32,746,816 RGD:6484113
G Fes feline sarcoma oncogene JBrowse link 7 80,377,758 80,387,954 RGD:6484113
G Flt1 FMS-like tyrosine kinase 1 JBrowse link 5 147,561,604 147,726,438 RGD:1626621
RGD:6484113
RGD:2298727
G Flt4 FMS-like tyrosine kinase 4 JBrowse link 11 49,609,679 49,652,739 RGD:6484113
G Fyn Fyn proto-oncogene JBrowse link 10 39,369,743 39,565,381 RGD:2298729
RGD:6484113
G Gab1 growth factor receptor bound protein 2-associated protein 1 JBrowse link 8 80,764,431 80,880,519 RGD:6484113
G Grb10 growth factor receptor bound protein 10 JBrowse link 11 11,930,499 12,037,428 RGD:6484113
G Grb2 growth factor receptor bound protein 2 JBrowse link 11 115,644,045 115,708,597 RGD:6484113
G Hgs HGF-regulated tyrosine kinase substrate JBrowse link 11 120,467,605 120,483,984 RGD:6484113
G Hif1a hypoxia inducible factor 1, alpha subunit JBrowse link 12 73,901,324 73,947,554 RGD:2301848
G Hras Harvey rat sarcoma virus oncogene JBrowse link 7 141,189,934 141,194,019 RGD:6907045
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 JBrowse link 12 110,691,036 110,696,395 RGD:6484113
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 JBrowse link 17 45,567,778 45,573,261 RGD:6484113
G Hspb1 heat shock protein 1 JBrowse link 5 135,887,919 135,889,563 RGD:6907045
G Iqgap1 IQ motif containing GTPase activating protein 1 JBrowse link 7 80,711,583 80,815,549 RGD:6484113
G Itgav integrin alpha V JBrowse link 2 83,722,303 83,806,917 RGD:6484113
G Itgb3 integrin beta 3 JBrowse link 11 104,608,000 104,670,476 RGD:6484113
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:1626621
RGD:6907045
RGD:6484113
RGD:2301848
RGD:2298729
RGD:2298727
RGD:2292019
G Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:6907045
G Map2k1 mitogen-activated protein kinase kinase 1 JBrowse link 9 64,185,769 64,253,605 RGD:6484113
RGD:6907045
G Map2k2 mitogen-activated protein kinase kinase 2 JBrowse link 10 81,105,913 81,124,697 RGD:6484113
RGD:6907045
G Map2k3 mitogen-activated protein kinase kinase 3 JBrowse link 11 60,932,054 60,952,811 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 11 110,399,102 110,525,522 RGD:6484113
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6484113
RGD:6907045
G Mapk11 mitogen-activated protein kinase 11 JBrowse link 15 89,142,482 89,149,606 RGD:6484113
RGD:6907045
G Mapk12 mitogen-activated protein kinase 12 JBrowse link 15 89,130,584 89,141,577 RGD:6907045
G Mapk13 mitogen-activated protein kinase 13 JBrowse link 17 28,769,286 28,778,704 RGD:6907045
G Mapk14 mitogen-activated protein kinase 14 JBrowse link 17 28,691,342 28,748,405 RGD:6484113
RGD:6907045
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6484113
RGD:6907045
G Mapkapk2 MAP kinase-activated protein kinase 2 JBrowse link 1 131,053,700 131,097,871 RGD:6484113
RGD:6907045
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 JBrowse link 9 107,254,927 107,289,877 RGD:6907045
G Myof myoferlin JBrowse link 19 37,899,036 38,043,577 RGD:6484113
G Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 JBrowse link 9 100,494,302 100,546,134 RGD:2298729
RGD:6484113
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 JBrowse link 1 43,445,483 43,570,518 RGD:6484113
G Nedd4 neural precursor cell expressed, developmentally down-regulated 4 JBrowse link 9 72,662,331 72,749,851 RGD:6484113
G Nfat5 nuclear factor of activated T cells 5 JBrowse link 8 107,293,435 107,379,517 RGD:6907045
G Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 JBrowse link 18 80,606,205 80,713,071 RGD:6907045
G Nfatc2 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 JBrowse link 2 168,476,410 168,601,657 RGD:6907045
G Nfatc3 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 JBrowse link 8 106,058,818 106,130,537 RGD:6907045
G Nfatc4 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 JBrowse link 14 55,824,795 55,833,943 RGD:6907045
G Nos3 nitric oxide synthase 3, endothelial cell JBrowse link 5 24,364,816 24,384,474 RGD:6484113
RGD:6907045
G Nras neuroblastoma ras oncogene JBrowse link 3 103,058,285 103,067,914 RGD:6907045
G Nrp1 neuropilin 1 JBrowse link 8 128,358,591 128,505,476 RGD:2298727
RGD:6484113
G Nrp2 neuropilin 2 JBrowse link 1 62,703,317 62,818,692 RGD:6484113
G Pak2 p21 (RAC1) activated kinase 2 JBrowse link 16 32,016,290 32,079,342 RGD:6484113
G Pdpk1 3-phosphoinositide dependent protein kinase 1 JBrowse link 17 24,073,680 24,155,619 RGD:6484113
G Pgf placental growth factor JBrowse link 12 85,166,637 85,177,785 RGD:2298727
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha JBrowse link 3 32,397,059 32,468,486 RGD:6484113
RGD:6907045
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta JBrowse link 9 99,038,402 99,140,235 RGD:6907045
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta JBrowse link 4 149,649,168 149,702,566 RGD:6907045
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma JBrowse link 12 32,173,397 32,208,677 RGD:6907045
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 13 101,680,761 101,768,217 RGD:6484113
RGD:6907045
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 JBrowse link 8 70,768,176 70,776,712 RGD:6907045
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 JBrowse link 4 116,221,400 116,303,056 RGD:6907045
G Pik3r5 phosphoinositide-3-kinase regulatory subunit 5 JBrowse link 11 68,432,125 68,497,849 RGD:6907045
G Pla2g10 phospholipase A2, group X JBrowse link 16 13,715,057 13,731,094 RGD:6907045
G Pla2g12a phospholipase A2, group XIIA JBrowse link 3 129,878,606 129,895,825 RGD:6907045
G Pla2g12b phospholipase A2, group XIIB JBrowse link 10 59,403,420 59,421,976 RGD:6907045
G Pla2g1b phospholipase A2, group IB, pancreas JBrowse link 5 115,466,142 115,474,722 RGD:6907045
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) JBrowse link 4 138,831,857 138,835,189 RGD:6907045
G Pla2g2c phospholipase A2, group IIC JBrowse link 4 138,725,325 138,744,575 RGD:6907045
G Pla2g2d phospholipase A2, group IID JBrowse link 4 138,775,735 138,782,052 RGD:6907045
G Pla2g2e phospholipase A2, group IIE JBrowse link 4 138,877,911 138,882,817 RGD:6907045
G Pla2g2f phospholipase A2, group IIF JBrowse link 4 138,750,533 138,757,598 RGD:6907045
G Pla2g3 phospholipase A2, group III JBrowse link 11 3,488,158 3,499,346 RGD:6907045
G Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) JBrowse link 1 149,829,618 149,961,290 RGD:6907045
G Pla2g4b phospholipase A2, group IVB (cytosolic) JBrowse link 2 120,033,433 120,043,033 RGD:6907045
G Pla2g4d phospholipase A2, group IVD JBrowse link 2 120,265,866 120,289,069 RGD:6907045
G Pla2g4e phospholipase A2, group IVE JBrowse link 2 120,166,412 120,245,630 RGD:6907045
G Pla2g5 phospholipase A2, group V JBrowse link 4 138,799,247 138,863,562 RGD:6907045
G Pla2g6 phospholipase A2, group VI JBrowse link 15 79,286,228 79,328,385 RGD:6907045
G Plcg1 phospholipase C, gamma 1 JBrowse link 2 160,731,310 160,775,760 RGD:2298729
RGD:6907045
RGD:6484113
G Plcg2 phospholipase C, gamma 2 JBrowse link 8 117,498,275 117,635,142 RGD:6907045
G Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform JBrowse link 3 136,669,714 136,937,727 RGD:6907045
G Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform JBrowse link 14 20,499,364 20,546,573 RGD:6907045
G Ppp3cc protein phosphatase 3, catalytic subunit, gamma isoform JBrowse link 14 70,217,864 70,289,536 RGD:6907045
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) JBrowse link 11 17,159,298 17,200,380 RGD:6907045
G Ppp3r2 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) JBrowse link 4 49,678,747 49,681,983 RGD:6907045
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit JBrowse link 15 5,143,861 5,181,899 RGD:6484113
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit JBrowse link 4 105,029,649 105,109,898 RGD:6484113
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit JBrowse link 5 116,013,586 116,024,503 RGD:6484113
G Prkaca protein kinase, cAMP dependent, catalytic, alpha JBrowse link 8 83,972,978 83,996,444 RGD:6484113
G Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit JBrowse link 15 98,812,797 98,831,508 RGD:6484113
G Prkca protein kinase C, alpha JBrowse link 11 107,933,387 108,343,888 RGD:2298729
RGD:6907045
RGD:6484113
G Prkcb protein kinase C, beta JBrowse link 7 122,289,104 122,634,402 RGD:2298729
RGD:6907045
G Prkcd protein kinase C, delta JBrowse link 14 30,595,353 30,626,414 RGD:2298730
RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 4 155,260,118 155,361,428 RGD:2298729
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6907045
G Ptk2 PTK2 protein tyrosine kinase 2 JBrowse link 15 73,205,102 73,423,820 RGD:2298729
RGD:6907045
G Ptk2b PTK2 protein tyrosine kinase 2 beta JBrowse link 14 66,153,257 66,281,100 RGD:6484113
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 5 121,130,533 121,191,397 RGD:6484113
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 JBrowse link 6 124,720,707 124,738,709 RGD:6484113
G Ptprj protein tyrosine phosphatase, receptor type, J JBrowse link 2 90,429,756 90,580,694 RGD:6484113
G Pxn paxillin JBrowse link 5 115,491,970 115,555,987 RGD:6484113
RGD:6907045
G Rac1 Rac family small GTPase 1 JBrowse link 5 143,505,481 143,528,031 RGD:6907045
G Rac2 Rac family small GTPase 2 JBrowse link 15 78,559,169 78,572,783 RGD:6907045
G Rac3 Rac family small GTPase 3 JBrowse link 11 120,721,468 120,723,969 RGD:6907045
G Raf1 v-raf-leukemia viral oncogene 1 JBrowse link 6 115,618,569 115,676,635 RGD:6484113
RGD:6907045
G Rhoa ras homolog family member A JBrowse link 9 108,306,160 108,337,943 RGD:6484113
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 10,064,401 10,182,251 RGD:6484113
G Sh2d2a SH2 domain containing 2A JBrowse link 3 87,846,755 87,855,722 RGD:2298729
RGD:6907045
RGD:6484113
G Shb src homology 2 domain-containing transforming protein B JBrowse link 4 45,423,276 45,530,828 RGD:2298729
RGD:6484113
G Shc2 SHC (Src homology 2 domain containing) transforming protein 2 JBrowse link 10 79,617,934 79,637,918 RGD:6907045
G Sphk1 sphingosine kinase 1 JBrowse link 11 116,530,836 116,536,675 RGD:6907045
G Sphk2 sphingosine kinase 2 JBrowse link 7 45,709,463 45,718,002 RGD:6907045
G Src Rous sarcoma oncogene JBrowse link 2 157,423,906 157,471,838 RGD:6484113
RGD:6907045
G Vcl vinculin JBrowse link 14 20,929,383 21,033,676 RGD:6484113
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:1626621
RGD:6907045
RGD:2301956
RGD:2301848
RGD:2298727
RGD:2292019
G Vegfb vascular endothelial growth factor B JBrowse link 19 6,982,472 6,987,651 RGD:2298727
G Vegfc vascular endothelial growth factor C JBrowse link 8 54,077,532 54,186,454 RGD:2298727
RGD:6484113
G Vegfd vascular endothelial growth factor D JBrowse link X 164,373,522 164,402,650 RGD:2298727
RGD:6484113
G Vtn vitronectin JBrowse link 11 78,499,120 78,502,325 RGD:6484113
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:2292019
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdr kinase insert domain protein receptor JBrowse link 5 75,932,827 75,979,072 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 17 46,016,993 46,032,377 RGD:2292019

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6011
    signaling pathway 2476
      growth factor signaling pathway 519
        vascular endothelial growth factor signaling pathway 133
          altered vascular endothelial growth factor signaling pathway + 2
Path 2
Term Annotations click to browse term
  pathway 6011
    regulatory pathway 3631
      homeostasis pathway 1695
        cardiovascular system homeostasis pathway 423
          vascular endothelial growth factor signaling pathway 133
            altered vascular endothelial growth factor signaling pathway + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.