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ONTOLOGY REPORT - ANNOTATIONS


Term:altered signaling pathway
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Accession:PW:0000264 term browser browse the term
Definition:Those signaling pathways that deviate from what their normal course should be. Aberrant signaling pathways, alone or in combination with other pathways underlie many conditions, disorders and/or diseases.


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altered androgen signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:2326139
RGD:8693397
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 5 5,466,544 5,696,540 RGD:8693397
G Ncor2 nuclear receptor co-repressor 2 JBrowse link 12 36,871,917 37,033,701 RGD:8693397
altered ephrin - ephrin receptor bidirectional signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efna1 ephrin A1 JBrowse link 2 188,588,808 188,596,156 RGD:1304509
G Efna2 ephrin A2 JBrowse link 7 12,382,636 12,393,266 RGD:1304509
G Efna3 ephrin A3 JBrowse link 2 188,636,304 188,645,302 RGD:1304509
G Efnb1 ephrin B1 JBrowse link X 68,891,227 68,904,034 RGD:1304509
G Efnb3 ephrin B3 JBrowse link 10 56,161,431 56,168,819 RGD:1304509
G Epha3 Eph receptor A3 JBrowse link 11 421,253 783,037 RGD:1304509
G Epha7 Eph receptor A7 JBrowse link 5 43,602,744 43,761,198 RGD:1304509
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:5490965
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:5133241
RGD:5490965
RGD:5133242
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:4143515
RGD:5133243
G Tgfa transforming growth factor alpha JBrowse link 4 117,961,877 118,045,923 RGD:5490965
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map2k5 mitogen activated protein kinase kinase 5 JBrowse link 8 68,055,976 68,282,656 RGD:2298532
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:2298532
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:2293882
RGD:5133243
RGD:5133242
RGD:2298531
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:2306732
RGD:5490966
RGD:5490965
RGD:5133242
RGD:4143515
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:5133242
RGD:5133243
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase JBrowse link 4 147,532,040 147,592,769 RGD:2293882
altered Hedgehog signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Boc BOC cell adhesion associated, oncogene regulated JBrowse link 11 61,084,216 61,159,220 RGD:5490966
G Dhh desert hedgehog signaling molecule JBrowse link 7 140,575,288 140,580,783 RGD:634737
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:5491005
RGD:5490966
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:1303367
RGD:5490966
G Lrp2 LDL receptor related protein 2 JBrowse link 3 55,665,153 55,822,484 RGD:5490966
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:704355
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:628387
RGD:5490965
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:704355
altered hypoxia inducible factor pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Vhl von Hippel-Lindau tumor suppressor JBrowse link 4 145,580,869 145,587,835 RGD:6907133
altered insulin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ins2 insulin 2 JBrowse link 1 215,856,967 215,858,034 RGD:2313694
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2313694
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1580474
altered integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:5490966
G Itga1 integrin subunit alpha 1 JBrowse link 2 47,127,403 47,281,387 RGD:1302875
G Itga11 integrin subunit alpha 11 JBrowse link 8 67,566,874 67,683,973 RGD:5490966
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:1302879
RGD:5490966
G Itga5 integrin subunit alpha 5 JBrowse link 7 144,970,444 144,993,652 RGD:1302875
G Itga7 integrin subunit alpha 7 JBrowse link 7 3,355,079 3,383,886 RGD:70774
G Itga8 integrin subunit alpha 8 JBrowse link 17 79,321,893 79,676,927 RGD:633055
G Itga9 integrin subunit alpha 9 JBrowse link 8 127,271,029 127,576,709 RGD:5490966
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1302874
altered Jak-Stat signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1357939
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:1357939
altered leptin system pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insr insulin receptor JBrowse link 12 1,682,527 1,816,414 RGD:2290473
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:61790
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:61790
RGD:1600611
G Lepr_v2 leptin receptor, variant 2 RGD:2290292
altered melanocortin system pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agrp agouti related neuropeptide JBrowse link 19 37,525,941 37,584,875 RGD:1357925
G Mc4r melanocortin 4 receptor JBrowse link 18 62,612,838 62,614,725 RGD:1357925
G Pcsk1 proprotein convertase subtilisin/kexin type 1 JBrowse link 2 91,450,162 91,497,091 RGD:1357926
RGD:1357925
G Pomc proopiomelanocortin JBrowse link 6 28,382,937 28,388,771 RGD:1357925
RGD:1357926
G Sdc1 syndecan 1 JBrowse link 6 33,885,576 33,908,038 RGD:1357925
altered Notch signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll1 delta like canonical Notch ligand 1 JBrowse link 1 57,318,621 57,326,732 RGD:1304492
G Dll3 delta like canonical Notch ligand 3 JBrowse link 1 85,485,875 85,493,683 RGD:1304493
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1334460
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:1304484
G Jag2 jagged canonical Notch ligand 2 JBrowse link 6 137,711,144 137,733,331 RGD:1304492
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:724389
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:69906
G Notch4 notch receptor 4 JBrowse link 20 4,329,794 4,353,868 RGD:1304484
G Numb NUMB, endocytic adaptor protein JBrowse link 6 107,279,917 107,325,345 RGD:1334451
G Pofut1 protein O-fucosyltransferase 1 JBrowse link 3 148,722,864 148,749,743 RGD:1334453
altered Notch signaling pathway involving promoters term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 JBrowse link 2 95,320,147 95,322,701 RGD:1334460
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Numb NUMB, endocytic adaptor protein JBrowse link 6 107,279,917 107,325,345 RGD:1334451
G Pofut1 protein O-fucosyltransferase 1 JBrowse link 3 148,722,864 148,749,743 RGD:1334453
G Psen2 presenilin 2 JBrowse link 13 98,513,600 98,539,347 RGD:2302525
altered Notch signaling pathway involving the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dll3 delta like canonical Notch ligand 3 JBrowse link 1 85,485,875 85,493,683 RGD:1304493
G Jag1 jagged canonical Notch ligand 1 JBrowse link 3 130,079,361 130,114,781 RGD:1334443
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1334450
G Notch3 notch receptor 3 JBrowse link 7 14,138,495 14,189,688 RGD:1334442
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ets1 ETS proto-oncogene 1, transcription factor JBrowse link 8 33,756,634 33,879,625 RGD:8663430
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:2316186
RGD:8663434
G Mdm4 MDM4 regulator of p53 JBrowse link 13 49,786,776 49,828,780 RGD:8663434
G Mre11 MRE11 homolog, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:8663431
G Nfya nuclear transcription factor Y subunit alpha JBrowse link 9 14,551,752 14,577,002 RGD:8663431
RGD:8663430
G Nfyb nuclear transcription factor Y subunit beta JBrowse link 7 27,081,667 27,097,481 RGD:8663431
RGD:8663430
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link 5 139,687,442 139,760,154 RGD:8663431
RGD:8663430
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 8 21,669,236 21,680,615 RGD:8663430
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:8663431
RGD:8663430
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:2316186
RGD:8693397
RGD:8663430
RGD:8663431
RGD:5490966
RGD:5133242
RGD:4143515
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:8663431
RGD:8663430
G Tp73 tumor protein p73 JBrowse link 5 171,355,876 171,415,354 RGD:8663431
RGD:8663430
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:8663430
altered phosphatidylinositol 3-kinase signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:8693397
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:8693397
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:2313763
RGD:5133243
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313763
RGD:2313408
RGD:5490965
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:2313763
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:2313763
RGD:5133243
RGD:5133242
RGD:4143515
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:2313763
RGD:5490965
RGD:5133242
RGD:4143515
RGD:2326139
altered Reelin signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dab1 DAB adaptor protein 1 JBrowse link 5 123,154,360 124,279,170 RGD:727518
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:2324970
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:2325851
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:2325851
G Lrp8 LDL receptor related protein 8 JBrowse link 5 127,404,348 127,476,636 RGD:2324974
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 JBrowse link 10 61,456,144 61,577,412 RGD:4107040
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 JBrowse link 8 50,256,969 50,310,043 RGD:4107040
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 JBrowse link 1 82,163,733 82,166,259 RGD:4107040
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:727518
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:2325284
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:1358468
altered scatter factor/hepatocyte growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:5133241
RGD:5490965
RGD:5133243
RGD:5133242
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Smad2 SMAD family member 2 JBrowse link 18 72,550,107 72,612,078 RGD:2306282
RGD:2308865
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:2306282
RGD:5490966
G Smad4 SMAD family member 4 JBrowse link 18 69,626,682 69,657,373 RGD:2306282
RGD:5490965
RGD:5490966
RGD:2308865
G Smad7 SMAD family member 7 JBrowse link 18 71,395,830 71,424,164 RGD:2308865
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:2299005
RGD:2306282
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:2299005
RGD:2306282
G Tgfbr2 transforming growth factor, beta receptor 2 JBrowse link 8 124,310,288 124,399,345 RGD:2299005
RGD:5490965
RGD:5490966
RGD:2306282
RGD:2308865
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 Fms related receptor tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1334463
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2292019
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt4 Fms related receptor tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:1334463
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:2292019
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:2292019
altered visual phototransduction pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 JBrowse link 14 38,155,771 38,171,107 RGD:8547536
G Cngb1 cyclic nucleotide gated channel subunit beta 1 JBrowse link 19 10,142,440 10,206,618 RGD:8547536
G Guca1b guanylate cyclase activator 1B JBrowse link 9 15,621,083 15,629,017 RGD:8547536
G Pde6a phosphodiesterase 6A JBrowse link 18 56,544,652 56,617,480 RGD:8547536
G Pde6b phosphodiesterase 6B JBrowse link 14 2,328,690 2,371,913 RGD:8547536
G Pde6g phosphodiesterase 6G JBrowse link 10 109,620,499 109,625,214 RGD:8547536
G Rho rhodopsin JBrowse link 4 147,832,136 147,837,298 RGD:8547536
G Sag S-antigen visual arrestin JBrowse link 9 94,926,901 94,972,162 RGD:8547536
altered Wnt signaling, canonical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:2293188
G Axin1 axin 1 RGD:2293188
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:2293188
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:2293188
RGD:4143515
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:2293188
G Tcf7l2 transcription factor 7 like 2 JBrowse link 1 276,686,911 276,730,517 RGD:5490966
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:5490966

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.