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ONTOLOGY REPORT - ANNOTATIONS


Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.

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integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein JBrowse link 2 22,755,971 22,875,653 RGD:2300340
G Fabp3 fatty acid binding protein 3, muscle and heart JBrowse link 4 130,308,738 130,315,463 RGD:7364738
G Fblim1 filamin binding LIM protein 1 JBrowse link 4 141,576,062 141,606,052 RGD:7349373
G Fermt1 fermitin family member 1 JBrowse link 2 132,904,177 132,946,036 RGD:7349373
G Fermt2 fermitin family member 2 JBrowse link 14 45,458,792 45,530,310 RGD:7349373
G Fermt3 fermitin family member 3 JBrowse link 19 6,998,958 7,019,469 RGD:7349373
G Flna filamin, alpha JBrowse link X 74,223,461 74,249,854 RGD:7364738
G Flnb filamin, beta JBrowse link 14 7,817,921 7,951,588 RGD:7364738
G Flnc filamin C, gamma JBrowse link 6 29,433,153 29,461,889 RGD:7364738
G Ilk integrin linked kinase JBrowse link 7 105,736,590 105,742,925 RGD:2300344
RGD:2302091
G Ilkap integrin-linked kinase-associated serine/threonine phosphatase 2C JBrowse link 1 91,373,846 91,398,844 RGD:2300344
G Itga1 integrin alpha 1 JBrowse link 13 114,958,079 115,101,964 RGD:5135538
G Itga10 integrin, alpha 10 JBrowse link 3 96,645,584 96,664,519 RGD:5135538
G Itga11 integrin alpha 11 JBrowse link 9 62,677,855 62,783,979 RGD:5135538
G Itga2 integrin alpha 2 JBrowse link 13 114,833,081 114,932,100 RGD:5135538
G Itga2b integrin alpha 2b JBrowse link 11 102,453,297 102,469,883 RGD:5135538
G Itga3 integrin alpha 3 JBrowse link 11 95,044,475 95,076,844 RGD:5135538
RGD:1358329
G Itga4 integrin alpha 4 JBrowse link 2 79,255,426 79,333,114 RGD:5135538
G Itga5 integrin alpha 5 (fibronectin receptor alpha) JBrowse link 15 103,344,286 103,366,791 RGD:5135538
G Itga6 integrin alpha 6 JBrowse link 2 71,786,886 71,858,427 RGD:5135538
G Itga7 integrin alpha 7 JBrowse link 10 128,933,421 128,958,286 RGD:5135538
G Itga8 integrin alpha 8 JBrowse link 2 12,106,632 12,301,985 RGD:5135538
G Itga9 integrin alpha 9 JBrowse link 9 118,606,709 118,901,003 RGD:5135538
G Itgad integrin, alpha D JBrowse link 7 128,173,933 128,205,504 RGD:5135538
G Itgae integrin alpha E, epithelial-associated JBrowse link 11 73,090,505 73,147,449 RGD:5135538
G Itgal integrin alpha L JBrowse link 7 127,296,139 127,335,137 RGD:5135538
G Itgam integrin alpha M JBrowse link 7 128,062,640 128,118,491 RGD:5135538
G Itgav integrin alpha V JBrowse link 2 83,722,303 83,806,917 RGD:1625134
RGD:5135538
G Itgax integrin alpha X JBrowse link 7 128,129,526 128,150,657 RGD:5135538
G Itgb1 integrin beta 1 (fibronectin receptor beta) JBrowse link 8 128,685,654 128,733,579 RGD:1625134
RGD:5135538
G Itgb1bp1 integrin beta 1 binding protein 1 JBrowse link 12 21,267,246 21,286,292 RGD:7349373
RGD:7364738
G Itgb2 integrin beta 2 JBrowse link 10 77,530,329 77,565,708 RGD:5135538
G Itgb3 integrin beta 3 JBrowse link 11 104,608,000 104,670,476 RGD:1625134
RGD:5135538
G Itgb4 integrin beta 4 JBrowse link 11 115,974,725 116,008,412 RGD:5135538
G Itgb5 integrin beta 5 JBrowse link 16 33,829,665 33,949,338 RGD:5135538
G Itgb6 integrin beta 6 JBrowse link 2 60,598,292 60,722,603 RGD:5135538
G Itgb7 integrin beta 7 JBrowse link 15 102,215,994 102,233,405 RGD:5135538
G Itgb8 integrin beta 8 JBrowse link 12 119,162,803 119,238,276 RGD:5135538
G Krit1 KRIT1, ankyrin repeat containing JBrowse link 5 3,803,156 3,844,515 RGD:7349373
RGD:7364738
G Lims1 LIM and senescent cell antigen-like domains 1 JBrowse link 10 58,323,342 58,424,691 RGD:2300344
G Lims2 LIM and senescent cell antigen like domains 2 JBrowse link 18 31,922,293 31,958,620 RGD:2300344
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 JBrowse link 1 43,445,483 43,570,518 RGD:2300344
G Parva parvin, alpha JBrowse link 7 112,427,706 112,591,688 RGD:2300344
G Parvb parvin, beta JBrowse link 15 84,232,043 84,315,689 RGD:2300344
G Parvg parvin, gamma JBrowse link 15 84,324,175 84,342,978 RGD:2300344
G Ptk2 PTK2 protein tyrosine kinase 2 JBrowse link 15 73,205,102 73,423,820 RGD:2300402
G Pxn paxillin JBrowse link 5 115,491,970 115,555,987 RGD:2300344
G Sharpin SHANK-associated RH domain interacting protein JBrowse link 15 76,347,040 76,351,110 RGD:7349373
RGD:7364738
G Tln1 talin 1 JBrowse link 4 43,531,513 43,562,583 RGD:2300340
RGD:7349373
G Tln2 talin 2 JBrowse link 9 67,217,085 67,634,045 RGD:7349373
altered integrin mediated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ilk integrin linked kinase JBrowse link 7 105,736,590 105,742,925 RGD:5490966
G Itga11 integrin alpha 11 JBrowse link 9 62,677,855 62,783,979 RGD:5490966
G Itga4 integrin alpha 4 JBrowse link 2 79,255,426 79,333,114 RGD:5490966
G Itga9 integrin alpha 9 JBrowse link 9 118,606,709 118,901,003 RGD:5490966

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  pathway 6011
    signaling pathway 2477
      mechanotransduction pathway 69
        integrin mediated signaling pathway 50
          altered integrin mediated signaling pathway 4
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.