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ONTOLOGY REPORT - ANNOTATIONS


Term:hypertrophic cardiomyopathy pathway
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Accession:PW:0000296 term browser browse the term
Definition:Hypertrophic cardiomyopathy, or HCM, is a disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is thickened. Many physiological and pathological conditions as well as many pathways underlie the hypertrophic response.
Synonyms:exact_synonym: HCM pathway
 related_synonym: KEGG:05410


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hypertrophic cardiomyopathy pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 JBrowse link 11 105,967,948 105,989,964 RGD:6907045
G Actb actin, beta JBrowse link 5 142,903,115 142,907,976 RGD:6907045
G Actc1 actin, alpha, cardiac muscle 1 JBrowse link 2 114,047,282 114,052,875 RGD:6907045
G Actg1 actin, gamma, cytoplasmic 1 JBrowse link 11 120,345,687 120,348,495 RGD:6907045
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 JBrowse link 5 122,453,513 122,502,225 RGD:6907045
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit JBrowse link 6 118,587,240 119,197,384 RGD:6907045
G Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit JBrowse link 14 30,039,941 30,491,156 RGD:6907045
G Cacna1f calcium channel, voltage-dependent, alpha 1F subunit JBrowse link X 7,607,103 7,635,196 RGD:6907045
G Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit JBrowse link 1 136,052,806 136,119,822 RGD:6907045
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 JBrowse link 5 15,934,264 16,374,511 RGD:6907045
G Cacna2d2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 JBrowse link 9 107,399,733 107,529,346 RGD:6907045
G Cacna2d3 calcium channel, voltage-dependent, alpha2/delta subunit 3 JBrowse link 14 28,904,943 29,722,775 RGD:6907045
G Cacna2d4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 JBrowse link 6 119,236,524 119,352,407 RGD:6907045
G Cacnb1 calcium channel, voltage-dependent, beta 1 subunit JBrowse link 11 98,001,508 98,023,034 RGD:6907045
G Cacnb2 calcium channel, voltage-dependent, beta 2 subunit JBrowse link 2 14,603,861 14,988,811 RGD:6907045
G Cacnb3 calcium channel, voltage-dependent, beta 3 subunit JBrowse link 15 98,628,436 98,644,536 RGD:6907045
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit JBrowse link 2 52,428,320 52,676,609 RGD:6907045
G Cacng1 calcium channel, voltage-dependent, gamma subunit 1 JBrowse link 11 107,703,218 107,716,476 RGD:6907045
G Cacng2 calcium channel, voltage-dependent, gamma subunit 2 JBrowse link 15 77,991,919 78,120,220 RGD:6907045
G Cacng3 calcium channel, voltage-dependent, gamma subunit 3 JBrowse link 7 122,671,744 122,769,393 RGD:6907045
G Cacng4 calcium channel, voltage-dependent, gamma subunit 4 JBrowse link 11 107,732,357 107,794,706 RGD:6907045
G Cacng5 calcium channel, voltage-dependent, gamma subunit 5 JBrowse link 11 107,874,604 107,915,055 RGD:6907045
G Cacng6 calcium channel, voltage-dependent, gamma subunit 6 JBrowse link 7 3,423,588 3,435,667 RGD:6907045
G Cacng7 calcium channel, voltage-dependent, gamma subunit 7 JBrowse link 7 3,332,027 3,368,221 RGD:6907045
G Cacng8 calcium channel, voltage-dependent, gamma subunit 8 JBrowse link 7 3,394,042 3,416,266 RGD:6907045
G Dag1 dystroglycan 1 JBrowse link 9 108,204,861 108,263,977 RGD:6907045
G Des desmin JBrowse link 1 75,360,292 75,368,579 RGD:6907045
G Dmd dystrophin, muscular dystrophy JBrowse link X 82,814,664 85,205,050 RGD:6907045
G Emd emerin JBrowse link X
X
74,261,032
74,254,674
74,261,563
74,261,563
RGD:6907045
G Igf1 insulin-like growth factor 1 JBrowse link 10 87,858,265 87,937,047 RGD:6907045
G Il6 interleukin 6 JBrowse link 5 30,013,114 30,019,975 RGD:6907045
G Itga1 integrin alpha 1 JBrowse link 13 114,958,079 115,101,964 RGD:6907045
G Itga10 integrin, alpha 10 JBrowse link 3 96,645,584 96,664,519 RGD:6907045
G Itga11 integrin alpha 11 JBrowse link 9 62,677,855 62,783,979 RGD:6907045
G Itga2 integrin alpha 2 JBrowse link 13 114,833,081 114,932,100 RGD:6907045
G Itga2b integrin alpha 2b JBrowse link 11 102,453,297 102,469,883 RGD:6907045
G Itga3 integrin alpha 3 JBrowse link 11 95,044,475 95,076,844 RGD:6907045
G Itga4 integrin alpha 4 JBrowse link 2 79,255,426 79,333,114 RGD:6907045
G Itga5 integrin alpha 5 (fibronectin receptor alpha) JBrowse link 15 103,344,286 103,366,791 RGD:6907045
G Itga6 integrin alpha 6 JBrowse link 2 71,786,886 71,858,427 RGD:6907045
G Itga7 integrin alpha 7 JBrowse link 10 128,933,421 128,958,286 RGD:6907045
G Itga8 integrin alpha 8 JBrowse link 2 12,106,632 12,301,985 RGD:6907045
G Itga9 integrin alpha 9 JBrowse link 9 118,606,709 118,901,003 RGD:6907045
G Itgav integrin alpha V JBrowse link 2 83,722,303 83,806,917 RGD:6907045
G Itgb1 integrin beta 1 (fibronectin receptor beta) JBrowse link 8 128,685,654 128,733,579 RGD:6907045
G Itgb3 integrin beta 3 JBrowse link 11 104,608,000 104,670,476 RGD:6907045
G Itgb4 integrin beta 4 JBrowse link 11 115,974,725 116,008,412 RGD:6907045
G Itgb5 integrin beta 5 JBrowse link 16 33,829,665 33,949,338 RGD:6907045
G Itgb6 integrin beta 6 JBrowse link 2 60,598,292 60,722,603 RGD:6907045
G Itgb7 integrin beta 7 JBrowse link 15 102,215,994 102,233,405 RGD:6907045
G Itgb8 integrin beta 8 JBrowse link 12 119,162,803 119,238,276 RGD:6907045
G Lama2 laminin, alpha 2 JBrowse link 10 26,981,285 27,617,191 RGD:6907045
G Lmna lamin A JBrowse link 3 88,481,148 88,509,932 RGD:6907045
G Mybpc3 myosin binding protein C, cardiac JBrowse link 2 91,118,114 91,136,516 RGD:6907045
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha JBrowse link 14 54,941,921 54,968,017 RGD:6907045
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta JBrowse link 14 54,970,684 54,994,626 RGD:6907045
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow JBrowse link 5 122,100,925 122,114,536 RGD:6907045
G Myl3 myosin, light polypeptide 3 JBrowse link 9 110,763,678 110,769,802 RGD:6907045
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit JBrowse link 15 5,143,861 5,181,899 RGD:6907045
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit JBrowse link 4 105,029,649 105,109,898 RGD:6907045
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit JBrowse link 5 116,013,586 116,024,503 RGD:6907045
G Prkab2 protein kinase, AMP-activated, beta 2 non-catalytic subunit JBrowse link 3 97,658,211 97,673,812 RGD:6907045
G Prkag1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit JBrowse link 15 98,812,797 98,831,508 RGD:6907045
G Prkag2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit JBrowse link 5 24,862,735 25,106,282 RGD:6907045
G Prkag3 protein kinase, AMP-activated, gamma 3 non-catalytic subunit JBrowse link 1 74,738,922 74,749,471 RGD:6907045
G Ryr2 ryanodine receptor 2, cardiac JBrowse link 13 11,553,099 12,106,945 RGD:6907045
G Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) JBrowse link 11 94,962,777 94,976,327 RGD:6907045
G Sgcb sarcoglycan, beta (dystrophin-associated glycoprotein) JBrowse link 5 73,632,749 73,647,737 RGD:6907045
G Sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) JBrowse link 11 46,971,077 47,989,451 RGD:6907045
G Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) JBrowse link 14 61,219,106 61,275,062 RGD:6907045
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 JBrowse link 17 81,373,105 81,738,387 RGD:6907045
G Tgfb1 transforming growth factor, beta 1 JBrowse link 7 25,687,002 25,705,077 RGD:6907045
G Tgfb2 transforming growth factor, beta 2 JBrowse link 1 186,622,787 186,709,697 RGD:6907045
G Tgfb3 transforming growth factor, beta 3 JBrowse link 12 86,056,743 86,079,041 RGD:6907045
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6907045
G Tnnc1 troponin C, cardiac/slow skeletal JBrowse link 14 31,208,312 31,211,729 RGD:6907045
G Tnni3 troponin I, cardiac 3 JBrowse link 7 4,518,305 4,522,718 RGD:6907045
G Tnnt2 troponin T2, cardiac JBrowse link 1 135,836,315 135,852,268 RGD:6907045
G Tpm1 tropomyosin 1, alpha JBrowse link 9 67,022,590 67,049,672 RGD:6907045
G Tpm2 tropomyosin 2, beta JBrowse link 4 43,513,726 43,523,583 RGD:6907045
G Tpm3 tropomyosin 3, gamma JBrowse link 3 90,072,651 90,100,902 RGD:6907045
G Tpm4 tropomyosin 4 JBrowse link 8 72,135,288 72,153,142 RGD:6907045
G Ttn titin JBrowse link 2 76,703,980 76,982,557 RGD:6907045

Term paths to the root
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Term Annotations click to browse term
  pathway 6011
    disease pathway 2078
      cardiovascular system disease pathway 255
        cardiomyopathy pathway 196
          hypertrophic cardiomyopathy pathway 83
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.