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ONTOLOGY REPORT - ANNOTATIONS


Term:p53-dependent G1/S DNA damage checkpoint pathway
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Accession:PW:0000303 term browser browse the term
Definition:The p53-dependent pathway of G1 arrest in response to damaged DNA.
Synonyms:related_synonym: ATM pathway


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p53-dependent G1/S DNA damage checkpoint pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CCNE1 cyclin E1 JBrowse link 19 35,497,576 35,509,289 RGD:9068941
G TP53 tumor protein p53 JBrowse link 17 7,687,132 7,706,120 RGD:9068941
altered p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ETS1 ETS proto-oncogene 1, transcription factor JBrowse link 11 127,174,721 127,302,834 RGD:9068941
G MDM2 MDM2 proto-oncogene JBrowse link 12 69,102,083 69,133,278 RGD:9068941
G MDM4 MDM4 regulator of p53 JBrowse link 1 184,406,124 184,439,344 RGD:9068941
G MRE11 MRE11 homolog, double strand break repair nuclease JBrowse link 11 92,908,403 92,985,966 RGD:9068941
G NFYA nuclear transcription factor Y subunit alpha JBrowse link 6 41,969,561 41,999,279 RGD:9068941
G NFYB nuclear transcription factor Y subunit beta JBrowse link 12 105,089,028 105,108,825 RGD:9068941
G NFYC nuclear transcription factor Y subunit gamma JBrowse link 1 41,304,194 41,383,615 RGD:9068941
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 19 10,053,733 10,067,343 RGD:9068941
G SREBF2 sterol regulatory element binding transcription factor 2 JBrowse link 22 40,811,459 40,884,947 RGD:9068941
G TP53 tumor protein p53 JBrowse link 17 7,687,132 7,706,120 RGD:9068941
G TP63 tumor protein p63 JBrowse link 3 195,172,810 195,473,085 RGD:9068941
G TP73 tumor protein p73 JBrowse link 1 3,476,064 3,529,206 RGD:9068941
G VDR vitamin D receptor JBrowse link 12 41,661,688 41,766,192 RGD:9068941
p53 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 9 130,482,852 130,652,941 RGD:9068941
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 8 142,221,371 142,277,665 RGD:9068941
G AKT1 AKT serine/threonine kinase 1 JBrowse link 14 105,211,645 105,236,756 RGD:9068941
G APAF1 apoptotic peptidase activating factor 1 JBrowse link 12 99,637,622 99,726,946 RGD:9068941
G ATM ATM serine/threonine kinase JBrowse link 11 106,584,228 106,728,457 RGD:9068941
G ATR ATR serine/threonine kinase JBrowse link 3 147,074,993 147,204,399 RGD:9068941
G BAX BCL2 associated X, apoptosis regulator JBrowse link 19 54,793,594 54,800,466 RGD:9068941
G BBC3 BCL2 binding component 3 JBrowse link 19 52,727,826 52,738,535 RGD:9068941
G BID BH3 interacting domain death agonist JBrowse link 22 16,594,186 16,633,695 RGD:9068941
G BRCA1 BRCA1 DNA repair associated JBrowse link 17 14,429,601 14,506,815 RGD:9068941
G CASP3 caspase 3 JBrowse link 4 189,018,422 189,040,217 RGD:9068941
G CASP8 caspase 8 JBrowse link 2B 206,645,803 206,696,468 RGD:9068941
G CASP9 caspase 9 JBrowse link 1 15,624,666 15,656,266 RGD:9068941
G CCNA2 cyclin A2 JBrowse link 4 125,153,810 125,161,370 RGD:9068941
G CCNB1 cyclin B1 JBrowse link 5 46,394,362 46,405,332 RGD:9068941
G CCNB2 cyclin B2 JBrowse link 15 56,382,391 56,402,299 RGD:9068941
G CCNB3 cyclin B3 JBrowse link X 50,157,122 50,223,759 RGD:9068941
G CCND1 cyclin D1 JBrowse link 11 68,029,134 68,041,553 RGD:9068941
G CCND2 cyclin D2 JBrowse link 12 4,309,272 4,340,893 RGD:9068941
G CCND3 cyclin D3 JBrowse link 6 42,820,569 42,932,944 RGD:9068941
G CCNE1 cyclin E1 JBrowse link 19 35,497,576 35,509,289 RGD:9068941
G CCNE2 cyclin E2 JBrowse link 8 93,702,104 93,717,151 RGD:9068941
G CCNG1 cyclin G1 JBrowse link 5 165,591,279 165,598,728 RGD:9068941
G CCNG2 cyclin G2 JBrowse link 4 52,870,692 52,883,703 RGD:9068941
G CD82 CD82 molecule JBrowse link 11 45,020,362 45,075,876 RGD:9068941
G CDK1 cyclin dependent kinase 1 JBrowse link 10 59,647,993 59,664,434 RGD:9068941
G CDK2 cyclin dependent kinase 2 JBrowse link 12 33,189,934 33,195,945 RGD:9068941
G CDK4 cyclin dependent kinase 4 JBrowse link 12 31,434,594 31,438,876 RGD:9068941
G CDK6 cyclin dependent kinase 6 JBrowse link 7 98,198,740 98,430,305 RGD:9068941
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 37,436,963 37,445,599 RGD:9068941
G CDKN2A cyclin dependent kinase inhibitor 2A JBrowse link 9 22,420,748 22,447,243 RGD:9068941
G CHEK1 checkpoint kinase 1 JBrowse link 11 124,359,218 124,410,385 RGD:9068941
G CHEK2 checkpoint kinase 2 JBrowse link 22 27,455,226 27,512,555 RGD:9068941
G COP1 COP1 E3 ubiquitin ligase JBrowse link 1 155,155,860 155,425,664 RGD:9068941
G CREBBP CREB binding protein JBrowse link 16 3,820,507 3,974,200 RGD:9068941
G CSE1L chromosome segregation 1 like JBrowse link 20 46,452,485 46,502,202 RGD:9068941
G CSNK1A1 casein kinase 1 alpha 1 JBrowse link 5 150,929,397 150,985,930 RGD:9068941
G CSNK1D casein kinase 1 delta JBrowse link 17 82,461,764 82,494,348 RGD:9068941
G CSNK1G1 casein kinase 1 gamma 1 JBrowse link 15 61,410,414 61,594,180 RGD:9068941
G CSNK1G3 casein kinase 1 gamma 3 JBrowse link 5 124,683,567 124,786,916 RGD:9068941
G DAXX death domain associated protein JBrowse link 6 34,004,362 34,008,819 RGD:9068941
G DDB2 damage specific DNA binding protein 2 JBrowse link 11 47,714,723 47,738,761 RGD:9068941
G DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 JBrowse link 12 21,751,119 21,766,602 RGD:9068941
G E4F1 E4F transcription factor 1 JBrowse link 16 2,323,461 2,335,695 RGD:9068941
G EI24 EI24 autophagy associated transmembrane protein JBrowse link 11 124,302,289 124,317,346 RGD:9068941
G EP300 E1A binding protein p300 JBrowse link 22 40,079,214 40,168,936 RGD:9068941
G FAS Fas cell surface death receptor JBrowse link 10 89,199,070 89,244,884 RGD:9068941
G FBXO11 F-box protein 11 JBrowse link 2A 48,849,746 48,948,007 RGD:9068941
G GADD45A growth arrest and DNA damage inducible alpha JBrowse link 1 68,880,912 68,884,188 RGD:9068941
G GADD45B growth arrest and DNA damage inducible beta JBrowse link 19 2,451,837 2,453,992 RGD:9068941
G GADD45G growth arrest and DNA damage inducible gamma JBrowse link 9 88,740,411 88,741,965 RGD:9068941
G GSK3B glycogen synthase kinase 3 beta JBrowse link 3 123,856,047 124,126,747 RGD:9068941
G GTSE1 G2 and S-phase expressed 1 JBrowse link 22 45,362,777 45,394,920 RGD:9068941
G HDAC1 histone deacetylase 1 JBrowse link 1 32,585,791 32,626,408 RGD:9068941
G HIPK2 homeodomain interacting protein kinase 2 JBrowse link 7 143,991,085 144,149,159 RGD:9068941
G HUWE1 HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 JBrowse link X 53,855,404 54,005,383 RGD:9068941
G IGF1 insulin like growth factor 1 JBrowse link 12 103,385,911 103,463,264 RGD:9068941
G IGFBP3 insulin like growth factor binding protein 3 JBrowse link 7 46,681,856 46,690,240 RGD:9068941
G KAT2A lysine acetyltransferase 2A JBrowse link 17 15,416,075 15,424,197 RGD:9068941
G KAT2B lysine acetyltransferase 2B JBrowse link 3 20,286,080 20,399,970 RGD:9068941
G KAT5 lysine acetyltransferase 5 JBrowse link 11 64,405,088 64,412,667 RGD:9068941
G KAT8 lysine acetyltransferase 8 JBrowse link 16 31,486,288 31,500,185 RGD:9068941
G KMT5A lysine methyltransferase 5A JBrowse link 12 125,211,201 125,234,986 RGD:9068941
G LOC100986481 cytochrome c JBrowse link 7 25,396,013 25,398,549 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 6 36,788,233 36,871,114 RGD:9068941
G MAPK8 mitogen-activated protein kinase 8 RGD:9068941
G MAPK9 mitogen-activated protein kinase 9 JBrowse link 5 182,748,381 182,801,464 RGD:9068941
G MDM2 MDM2 proto-oncogene JBrowse link 12 69,102,083 69,133,278 RGD:9068941
G MDM4 MDM4 regulator of p53 JBrowse link 1 184,406,124 184,439,344 RGD:9068941
G MUC1 mucin 1, cell surface associated JBrowse link 1 134,141,969 134,146,791 RGD:9068941
G NEDD8 NEDD8 ubiquitin like modifier JBrowse link 14 23,117,271 23,132,249 RGD:9068941
G PERP p53 apoptosis effector related to PMP22 JBrowse link 6 139,931,031 139,947,785 RGD:9068941
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 JBrowse link 19 10,053,733 10,067,343 RGD:9068941
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 56,611,098 56,615,449 RGD:9068941
G POU4F1 POU class 4 homeobox 1 JBrowse link 13 78,863,468 78,863,992 RGD:9068941
G POU4F2 POU class 4 homeobox 2 JBrowse link 4 150,626,392 150,629,961 RGD:9068941
G PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D JBrowse link 17 59,824,566 59,887,015 RGD:9068941
G PPP1R13B protein phosphatase 1 regulatory subunit 13B JBrowse link 14 104,168,873 104,283,500 RGD:9068941
G PPP1R13L protein phosphatase 1 regulatory subunit 13 like JBrowse link 19 50,915,901 50,950,837 RGD:9068941
G PPP2CA protein phosphatase 2 catalytic subunit alpha JBrowse link 5 135,751,964 135,761,395 RGD:9068941
G PRKCD protein kinase C delta JBrowse link 3 54,330,328 54,357,910 RGD:9068941
G PRMT5 protein arginine methyltransferase 5 JBrowse link 14 21,836,984 21,846,018 RGD:9068941
G PTEN phosphatase and tensin homolog JBrowse link 10 88,093,539 88,197,902 RGD:9068941
G PTPA protein phosphatase 2 phosphatase activator JBrowse link 9 128,896,584 128,934,651 RGD:9068941
G RASSF1 Ras association domain family member 1 JBrowse link 3 51,491,548 51,502,386 RGD:9068941
G RCHY1 ring finger and CHY zinc finger domain containing 1 JBrowse link 4 54,526,197 54,561,054 RGD:9068941
G RPL11 ribosomal protein L11 JBrowse link 1 23,868,700 23,873,313 RGD:9068941
G RPL23 ribosomal protein L23 JBrowse link 17 18,690,682 18,694,434 RGD:9068941
G RPL5 ribosomal protein L5 JBrowse link 1 94,231,605 94,241,522 RGD:9068941
G RPRM reprimo, TP53 dependent G2 arrest mediator homolog JBrowse link 2B 158,008,875 158,010,364 RGD:9068941
G RRM2 ribonucleotide reductase regulatory subunit M2 JBrowse link 2A 10,275,598 10,284,640 RGD:9068941
G RRM2B ribonucleotide reductase regulatory TP53 inducible subunit M2B JBrowse link 8 101,016,069 101,052,235 RGD:9068941
G SERPINB5 serpin family B member 5 JBrowse link 18 60,148,552 60,176,624 RGD:9068941
G SERPINE1 serpin family E member 1 JBrowse link 7 106,511,539 106,518,605 RGD:9068941
G SESN1 sestrin 1 JBrowse link 6 110,839,631 110,945,723 RGD:9068941
G SESN2 sestrin 2 JBrowse link 1 28,555,072 28,577,931 RGD:9068941
G SESN3 sestrin 3 JBrowse link 11 93,707,191 93,773,762 RGD:9068941
G SETD7 SET domain containing 7, histone lysine methyltransferase JBrowse link 4 143,167,190 143,227,731 RGD:9068941
G SFN stratifin JBrowse link 1 27,182,629 27,184,075 RGD:9068941
G SHISA5 shisa family member 5 JBrowse link 3 49,471,604 49,508,840 RGD:9068941
G SIAH1 siah E3 ubiquitin protein ligase 1 JBrowse link 16 47,517,587 47,542,447 RGD:9068941
G SIRT1 sirtuin 1 JBrowse link 10 66,681,983 66,714,065 RGD:9068941
G SKP2 S-phase kinase associated protein 2 JBrowse link 5 79,460,989 79,493,000 RGD:9068941
G SMYD2 SET and MYND domain containing 2 JBrowse link 1 194,729,116 194,761,043 RGD:9068941
G STEAP3 STEAP3 metalloreductase JBrowse link 2B 119,760,650 119,787,051 RGD:9068941
G THBS1 thrombospondin 1 JBrowse link 15 36,776,756 36,793,469 RGD:9068941
G TNFRSF10B TNF receptor superfamily member 10b JBrowse link 8 19,209,895 19,258,498 RGD:9068941
G TP53 tumor protein p53 JBrowse link 17 7,687,132 7,706,120 RGD:9068941
G TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 JBrowse link 11 127,650,534 127,659,213 RGD:9068941
G TP53BP2 tumor protein p53 binding protein 2 JBrowse link 1 204,414,218 204,455,684 RGD:9068941
G TP53I3 tumor protein p53 inducible protein 3 JBrowse link 2A 24,172,607 24,180,903 RGD:9068941
G TP73 tumor protein p73 JBrowse link 1 3,476,064 3,529,206 RGD:9068941
G TRIM28 tripartite motif containing 28 JBrowse link 19 64,369,979 64,377,144 RGD:9068941
G TSC2 TSC complex subunit 2 JBrowse link 16 2,135,696 2,175,569 RGD:9068941
G TTC5 tetratricopeptide repeat domain 5 JBrowse link 14 19,214,337 19,233,797 RGD:9068941
G UBE2D1 ubiquitin conjugating enzyme E2 D1 JBrowse link 10 57,087,811 57,123,581 RGD:9068941
G USP7 ubiquitin specific peptidase 7 JBrowse link 16 9,065,366 9,106,406 RGD:9068941
G YBX1 Y-box binding protein 1 JBrowse link 1 43,360,052 43,380,313 RGD:9068941
G YY1 YY1 transcription factor JBrowse link 14 100,173,287 100,217,651 RGD:9068941
G ZMAT3 zinc finger matrin-type 3 JBrowse link 3 184,241,544 184,288,639 RGD:9068941
G ZNF385A zinc finger protein 385A JBrowse link 12 35,080,820 35,102,248 RGD:9068941
G ZNF420 zinc finger protein 420 JBrowse link 19 42,674,723 42,727,746 RGD:9068941
G ZNHIT1 zinc finger HIT-type containing 1 JBrowse link 7 106,599,579 106,606,157 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5624
    regulatory pathway 3442
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1601
        cell cycle pathway 225
          cell cycle checkpoint pathway 132
            G1/S DNA damage checkpoint pathway 131
              p53-dependent G1/S DNA damage checkpoint pathway 131
                p53 signaling pathway + 131
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.